Evidence map›Paper›PMID 28392840›Full record

ArticleCellular and molecular bioengineering2016

Elucidation of Exosome Migration across the Blood-Brain Barrier Model In Vitro.

Claire C Chen, Linan Liu, Fengxia Ma, Chi W Wong, Xuning E Guo, Jenu V Chacko, Henry P Farhoodi, Shirley X Zhang, Jan Zimak, Aude Ségaliny and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cellular and molecular bioengineering, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 328 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
328citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

328 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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268 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Claire C ChenDepartment of Pharmaceutical Sciences, Sue and Bill Gross Stem Cell Research Center, Chao Family Comprehensive Cancer Center and Edwards Life sciences Center for Advanced Cardiovascular Technology, 845 Health Sciences Road, University of California-Irvine, Irvine, California, 92697, USA; Department of Biomedical Engineering, University of California-Irvine, Irvine, California, 92697, USA.
Linan LiuDepartment of Pharmaceutical Sciences, Sue and Bill Gross Stem Cell Research Center, Chao Family Comprehensive Cancer Center and Edwards Life sciences Center for Advanced Cardiovascular Technology, 845 Health Sciences Road, University of California-Irvine, Irvine, California, 92697, USA; Department of Biomedical Engineering, University of California-Irvine, Irvine, California, 92697, USA.
Fengxia MaDepartment of Pharmaceutical Sciences, Sue and Bill Gross Stem Cell Research Center, Chao Family Comprehensive Cancer Center and Edwards Life sciences Center for Advanced Cardiovascular Technology, 845 Health Sciences Road, University of California-Irvine, Irvine, California, 92697, USA; Department of Biomedical Engineering, University of California-Irvine, Irvine, California, 92697, USA; State Key Laboratory of Experimental Hematology, Institute of Hematology and Blood Disease Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin 300020, China.
Chi W WongDepartment of Pharmaceutical Sciences, Sue and Bill Gross Stem Cell Research Center, Chao Family Comprehensive Cancer Center and Edwards Life sciences Center for Advanced Cardiovascular Technology, 845 Health Sciences Road, University of California-Irvine, Irvine, California, 92697, USA; Department of Biomedical Engineering, University of California-Irvine, Irvine, California, 92697, USA.
Xuning E GuoDepartment of Pharmaceutical Sciences, Sue and Bill Gross Stem Cell Research Center, Chao Family Comprehensive Cancer Center and Edwards Life sciences Center for Advanced Cardiovascular Technology, 845 Health Sciences Road, University of California-Irvine, Irvine, California, 92697, USA; Department of Biomedical Engineering, University of California-Irvine, Irvine, California, 92697, USA.
Jenu V ChackoDepartment of Biomedical Engineering, University of California-Irvine, Irvine, California, 92697, USA.
Henry P FarhoodiDepartment of Pharmaceutical Sciences, Sue and Bill Gross Stem Cell Research Center, Chao Family Comprehensive Cancer Center and Edwards Life sciences Center for Advanced Cardiovascular Technology, 845 Health Sciences Road, University of California-Irvine, Irvine, California, 92697, USA; Department of Biomedical Engineering, University of California-Irvine, Irvine, California, 92697, USA; Department of Molecular Biology & Biochemistry, University of California-Irvine, Irvine, California, 92697, USA.
Shirley X ZhangDepartment of Pharmaceutical Sciences, Sue and Bill Gross Stem Cell Research Center, Chao Family Comprehensive Cancer Center and Edwards Life sciences Center for Advanced Cardiovascular Technology, 845 Health Sciences Road, University of California-Irvine, Irvine, California, 92697, USA; Department of Biomedical Engineering, University of California-Irvine, Irvine, California, 92697, USA.
Jan ZimakDepartment of Pharmaceutical Sciences, Sue and Bill Gross Stem Cell Research Center, Chao Family Comprehensive Cancer Center and Edwards Life sciences Center for Advanced Cardiovascular Technology, 845 Health Sciences Road, University of California-Irvine, Irvine, California, 92697, USA; Department of Biomedical Engineering, University of California-Irvine, Irvine, California, 92697, USA.
Aude SégalinyDepartment of Pharmaceutical Sciences, Sue and Bill Gross Stem Cell Research Center, Chao Family Comprehensive Cancer Center and Edwards Life sciences Center for Advanced Cardiovascular Technology, 845 Health Sciences Road, University of California-Irvine, Irvine, California, 92697, USA; Department of Biomedical Engineering, University of California-Irvine, Irvine, California, 92697, USA.
Milad RiazifarDepartment of Pharmaceutical Sciences, Sue and Bill Gross Stem Cell Research Center, Chao Family Comprehensive Cancer Center and Edwards Life sciences Center for Advanced Cardiovascular Technology, 845 Health Sciences Road, University of California-Irvine, Irvine, California, 92697, USA; Department of Biomedical Engineering, University of California-Irvine, Irvine, California, 92697, USA.
Victor PhamDepartment of Pharmaceutical Sciences, Sue and Bill Gross Stem Cell Research Center, Chao Family Comprehensive Cancer Center and Edwards Life sciences Center for Advanced Cardiovascular Technology, 845 Health Sciences Road, University of California-Irvine, Irvine, California, 92697, USA; Department of Biomedical Engineering, University of California-Irvine, Irvine, California, 92697, USA.
Michelle A DigmanDepartment of Biomedical Engineering, University of California-Irvine, Irvine, California, 92697, USA; Laboratory for Fluorescence Dynamics, University of California-Irvine, California 92697, USA; Centre for Bioactive Discovery in Health and Ageing, School of Science and Technology, University of New England, Armidale, New South Wales 2351, Australia.
Egest J PoneDepartment of Pharmaceutical Sciences, Sue and Bill Gross Stem Cell Research Center, Chao Family Comprehensive Cancer Center and Edwards Life sciences Center for Advanced Cardiovascular Technology, 845 Health Sciences Road, University of California-Irvine, Irvine, California, 92697, USA; Department of Biomedical Engineering, University of California-Irvine, Irvine, California, 92697, USA.
Weian ZhaoDepartment of Pharmaceutical Sciences, Sue and Bill Gross Stem Cell Research Center, Chao Family Comprehensive Cancer Center and Edwards Life sciences Center for Advanced Cardiovascular Technology, 845 Health Sciences Road, University of California-Irvine, Irvine, California, 92697, USA; Department of Biomedical Engineering, University of California-Irvine, Irvine, California, 92697, USA.

Funding

Mechano-sensing stem cells to study, detect and treat cancer metastasesDP2CA195763 · NCI · UNIVERSITY OF CALIFORNIA-IRVINE · PI ZHAO, WEIAN · 2014 to 2014
$2.3M
NCI NIH HHS DP2 CA195763
6 · The paper itself

Abstract

The delivery of therapeutics to the central nervous system (CNS) remains a major challenge in part due to the presence of the blood-brain barrier (BBB). Recently, cell-derived vesicles, particularly exosomes, have emerged as an attractive vehicle for targeting drugs to the brain, but whether or how they cross the BBB remains unclear. Here, we investigated the interactions between exosomes and brain microvascular endothelial cells (BMECs)

Indexed as

blood-brain barrier (BBB)Drug deliveryendocytosisexocytosisexosomehumanized Gaussia luciferase (hGluc)inflammationstroketranscytosis

Identifiers

PMID28392840
PMCPMC5382965

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.