Evidence map›Paper›PMID 28392787›Full record

ArticleFrontiers in immunology2017

Bioconjugation of Small Molecules to RNA Impedes Its Recognition by Toll-Like Receptor 7.

Isabell Hellmuth, Isabel Freund, Janine Schlöder, Salifu Seidu-Larry, Kathrin Thüring, Kaouthar Slama, Jens Langhanki, Stefka Kaloyanova, Tatjana Eigenbrod, Matthias Krumb and 6 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.7field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Selectivity of 1-Molecules (Basel, Switzerland) · 2022
    Article
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 4 institutions in 1 country.

Isabell HellmuthInstitute of Pharmacy and Biochemistry, Johannes Gutenberg-University Mainz , Mainz , Germany.
Isabel FreundDepartment of Infectious Diseases, Medical Microbiology and Hygiene, University of Heidelberg , Heidelberg , Germany.
Janine SchlöderDepartment of Dermatology, University Medical Center of the Johannes Gutenberg-University Mainz , Mainz , Germany.
Salifu Seidu-LarryInstitute of Pharmacy and Biochemistry, Johannes Gutenberg-University Mainz , Mainz , Germany.
Kathrin ThüringInstitute of Pharmacy and Biochemistry, Johannes Gutenberg-University Mainz , Mainz , Germany.
Kaouthar SlamaInstitute of Pharmacy and Biochemistry, Johannes Gutenberg-University Mainz , Mainz , Germany.
Jens LanghankiInstitute of Organic Chemistry, Johannes Gutenberg-University Mainz , Mainz , Germany.
Stefka KaloyanovaMax Planck Institute for Polymer Research (MPG) , Mainz , Germany.
Tatjana EigenbrodDepartment of Infectious Diseases, Medical Microbiology and Hygiene, University of Heidelberg , Heidelberg , Germany.
Matthias KrumbInstitute of Organic Chemistry, Johannes Gutenberg-University Mainz , Mainz , Germany.
Sandra RöhmMax Planck Institute for Polymer Research (MPG) , Mainz , Germany.
Kalina PenevaMax Planck Institute for Polymer Research (MPG) , Mainz , Germany.
Till OpatzInstitute of Organic Chemistry, Johannes Gutenberg-University Mainz , Mainz , Germany.
Helmut JonuleitDepartment of Dermatology, University Medical Center of the Johannes Gutenberg-University Mainz , Mainz , Germany.
Alexander H DalpkeDepartment of Infectious Diseases, Medical Microbiology and Hygiene, University of Heidelberg , Heidelberg , Germany.
Mark HelmInstitute of Pharmacy and Biochemistry, Johannes Gutenberg-University Mainz , Mainz , Germany.
Johannes Gutenberg University Mainz · DEHeidelberg University · DEMax Planck Institute for Polymer Research · DEUniversity Medical Center of the Johannes Gutenberg University Mainz · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A fundamental mechanism of the innate immune system is the recognition,

Indexed as

bioconjugateclick chemistryimmunostimulationmRNAsiRNAsmall moleculestoll-like receptor

Identifiers

PMID28392787
PMCPMC5364167
OpenAlexW2599702163

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.