Evidence map›Paper›PMID 28392679›Full record

ArticlePatient preference and adherence2017

Depressive symptoms and adherence to cardiometabolic therapies across phases of treatment among adults with diabetes: the Diabetes Study of Northern California (DISTANCE).

Amy M Bauer, Melissa M Parker, Howard H Moffet, Dean Schillinger, Nancy E Adler, Alyce S Adams, Julie A Schmittdiel, Wayne J Katon, Andrew J Karter

Abstract read
In one paragraph

Article in Patient preference and adherence, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Amy M BauerDepartment of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, WA.
Melissa M ParkerKaiser Permanente Northern California, Oakland.
Howard H MoffetKaiser Permanente Northern California, Oakland.
Dean SchillingerDivision of General Internal Medicine, University of California, San Francisco; Center for Vulnerable Populations, San Francisco General Hospital and Trauma Center.
Nancy E AdlerDepartment of Psychiatry and Pediatrics, Center for Health and Community, University of California, San Francisco, CA, USA.
Alyce S AdamsKaiser Permanente Northern California, Oakland.
Julie A SchmittdielKaiser Permanente Northern California, Oakland.
Wayne J KatonDepartment of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, WA.
Andrew J KarterKaiser Permanente Northern California, Oakland.

Funding

Research BaseP30DK063720 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GERMAN, MICHAEL S · 2003 to 2019
$21.8M
NCCIH Supplement to NCATS/CTSA Program for KL2 Scholars - M. SoddersKL2TR002317 · NCATS · UNIVERSITY OF WASHINGTON · PI Christy Michelle McKinney · 2017 to 2026
$14.5M
Institute of Translational Health SciencesKL2TR000421 · NCATS · UNIVERSITY OF WASHINGTON · PI DISIS, MARY L. · 2012 to 2016
$12.6M
Translational Research Core - Health Engagement & Action Translational (HEAT)P30DK092924 · NIDDK · KAISER FOUNDATION RESEARCH INSTITUTE · PI Alyce Sophia Adams, HILARY Kessler SELIGMAN · 2011 to 2026
$9.2M
NCATS NIH HHS KL2 TR000421NCATS NIH HHS KL2 TR002317NIDDK NIH HHS P30 DK063720NIDDK NIH HHS P30 DK092924
6 · The paper itself

Abstract

objectiveAmong adults with diabetes, depression is associated with poorer adherence to cardiometabolic medications in ongoing users; however, it is unknown whether this extends to early adherence among patients newly prescribed these medications. This study examined whether depressive symptoms among adults with diabetes newly prescribed cardiometabolic medications are associated with early and long-term nonadherence. PATIENTS AND

methodsAn observational follow-up of 4,018 adults with type 2 diabetes who completed a survey in 2006 and were newly prescribed oral antihyperglycemic, antihypertensive, or lipid-lowering agents within the following year at Kaiser Permanente Northern California was conducted. Depressive symptoms were examined based on Patient Health Questionnaire-8 scores. Pharmacy utilization data were used to identify nonadherence by using validated methods: early nonadherence (medication never dispensed or dispensed once and never refilled) and long-term nonadherence (new prescription medication gap [NPMG]: percentage of time without medication supply). These analyses were conducted in 2016.

resultsPatients with moderate-to-severe depressive symptoms had poorer adherence than nondepressed patients (8.3% more patients with early nonadherence,

conclusionDepressive symptoms were associated with modest differences in early and long-term adherence to newly prescribed cardiometabolic medications in diabetes patients. Interventions targeting adherence among adults with diabetes and depression need to address both initiation and maintenance of medication use.

Indexed as

antihypertensivedepressiondiabetes mellitushypoglycemichypolipidemic agentsmedication adherenceobservational cohort studyPatient Health Questionnaire-8pharmacoepidemiologyPHQ-8type 2 diabetes

Identifiers

PMID28392679
PMCPMC5373834

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.