ArticleCellular & molecular immunology2018
M2-specific reduction of CD1d switches NKT cell-mediated immune responses and triggers metaflammation in adipose tissue.
Article in Cellular & molecular immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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Who cites it
25 citing papers in PubMed, 38 citations in OpenAlex.
- Can invariant Natural Killer T cells drive B cell fate? a look at the humoral response.Frontiers in immunology · 2025Review
- CD1 molecules: Beyond antigen presentation.Molecular immunology · 2024Review
- The effects of matrix stiffness on immune cells in bone biology.Mechanobiology in medicine · 2024Review
- Contribution of NKT cells and CD1d-expressing cells in obesity-associated adipose tissue inflammation.Frontiers in immunology · 2024Review
- Adipose tissue aging is regulated by an altered immune system.Frontiers in immunology · 2023Review
- EGFR tyrosine kinase activity and Rab GTPases coordinate EGFR trafficking to regulate macrophage activation in sepsis.Cell death & disease · 2022Article
- The Effect of Dietary Methyl-Donor Intake and Other Lifestyle Factors on Cancer Patients in Hungary.Cancers · 2022Article
- Human iNKT Cells Modulate Macrophage Survival and Phenotype.Biomedicines · 2022Article
- The iNKT Cell-Macrophage Axis in Homeostasis and Disease.International journal of molecular sciences · 2022Review
- The 'Jekyll and Hyde' of Gluconeogenesis: Early Life Adversity, Later Life Stress, and Metabolic Disturbances.International journal of molecular sciences · 2021Review
- Innate Immune System Orchestrates Metabolic Homeostasis and Dysfunction in Visceral Adipose Tissue During Obesity.Frontiers in immunology · 2021Review
- The COVID-19 Pandemic: Does Our Early Life Environment, Life Trajectory and Socioeconomic Status Determine Disease Susceptibility and Severity?International journal of molecular sciences · 2020Review
- Altered nutrient status reprograms host inflammation and metabolic health via gut microbiota.The Journal of nutritional biochemistry · 2020Review
- Leukocyte Heterogeneity in Adipose Tissue, Including in Obesity.Circulation research · 2020Review
- Roles of Hepatic Innate and Innate-Like Lymphocytes in Nonalcoholic Steatohepatitis.Frontiers in immunology · 2020Review
- Kupffer Cells Promote the Differentiation of Adult Liver Hematopoietic Stem and Progenitor Cells into Lymphocytes via ICAM-1 and LFA-1 Interaction.Stem cells international · 2019Article
- Tissue Immune Cells Fuel Obesity-Associated Inflammation in Adipose Tissue and Beyond.Frontiers in immunology · 2019Review
- Innate T Cells Govern Adipose Tissue Biology.Journal of immunology (Baltimore, Md. : 1950) · 2018Review
- Tissue-specific functions of invariant natural killer T cells.Nature reviews. Immunology · 2018Review
- CD4+ T cells memorize obesity and promote weight regain.Cellular & molecular immunology · 2018Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Metaflammation is responsible for several metabolic syndromes, such as type 2 diabetes. However, the mechanisms by which metabolic disorders trigger metaflammation remain unclear. We identified a cell type-specific downregulation of CD1d expression in M2 macrophages during the progression of obesity prior to the onset of inflammation in visceral adipose tissues. A reduction in CD1d expression influenced the ability of M2 macrophages to present antigens and caused a change in antigen-presenting cells from M2 macrophages to M1 macrophages. With CD1d conditional knockout (KO) mice, we further demonstrated that natural killer T (NKT) cell activation by M2 macrophages inhibited metaflammation and insulin resistance by promoting Th2 responses and M2 polarization in visceral adipose tissues of obese mice, whereas NKT cell activation by M1 macrophages exacerbated metaflammation and insulin resistance by promoting Th1 responses and inhibiting M2 polarization. Our results suggest that an M2-specific reduction of CD1d is an initiating event that switches NKT cell-mediated immune responses and disrupts the immune balance in visceral adipose tissues in obese mice.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.