ArticleNeuroImage2018
Intrinsic functional connectivity of the central nucleus of the amygdala and bed nucleus of the stria terminalis.
Article in NeuroImage, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00047853 (fMRI Investigation of Explicit Cue and Contextual Fear), which is not on this map. Cited by 44 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
fMRI Investigation of Explicit Cue and Contextual Fear
Who cites it
44 citing papers in PubMed, 65 citations in OpenAlex.
- Nx4 Modulated Resting-State Functional Connectivity Between Amygdala and Prefrontal Cortex in a Placebo-Controlled, Crossover Trial.Brain connectivity · 2022Trial
- Substantial evidence against sex differences in bed nucleus of the stria terminalis volume in the human brain.bioRxiv : the preprint server for biology · 2026Article
- Major depressive disorder is associated with reduced intrinsic connectivity between the bed nucleus of the stria terminalis and ventral striatum.Journal of psychiatry & neuroscience : JPN · 2026Article
- Sex and sobriety: Human brain structure and function in AUD abstinence.Alcohol (Fayetteville, N.Y.) · 2024Review
- The human social cognitive network contains multiple regions within the amygdala.Science advances · 2024Article
- Data-driven, connectome-wide analysis identifies psychosis-specific brain correlates of fear and anxiety.Molecular psychiatry · 2024Article
- Social cognitive regions of human association cortex are selectively connected to the amygdala.bioRxiv : the preprint server for biology · 2024Article
- Psychometric Properties, Factor Structure, and Validity of the Sensitivity to Threat and Affiliative Reward Scale in Children and Adults.Assessment · 2023Article
- Alterations in BNST Intrinsic Functional Connectivity in Early Abstinence from Alcohol Use Disorder.Alcohol and alcoholism (Oxford, Oxfordshire) · 2023Article
- The central extended amygdala guides survival-relevant tradeoffs: Implications for understanding common psychiatric disorders.Neuroscience and biobehavioral reviews · 2022Article
- Article
- Threat vigilance and intrinsic amygdala connectivity.Human brain mapping · 2022Article
- Reciprocal midbrain-extended amygdala circuit activity in preclinical models of alcohol use and misuse.Neuropharmacology · 2022Review
- Article
- Better living through understanding the insula: Why subregions can make all the difference.Neuropharmacology · 2021Review
- The regulatory roles of progesterone and estradiol on emotion processing in women.Cognitive, affective & behavioral neuroscience · 2021Article
- BNST and amygdala connectivity are altered during threat anticipation in schizophrenia.Behavioural brain research · 2021Article
- Review
- Alterations in connectivity of the bed nucleus of the stria terminalis during early abstinence in individuals with alcohol use disorder.Alcoholism, clinical and experimental research · 2021Article
- Extended-amygdala intrinsic functional connectivity networks: A population study.Human brain mapping · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
The central nucleus of the amygdala (CeA) and bed nucleus of the stria terminalis (BNST), two nuclei within the central extended amygdala, function as critical relays within the distributed neural networks that coordinate sensory, emotional, and cognitive responses to threat. These structures have overlapping anatomical projections to downstream targets that initiate defensive responses. Despite these commonalities, researchers have also proposed a functional dissociation between the CeA and BNST, with the CeA promoting responses to discrete stimuli and the BNST promoting responses to diffuse threat. Intrinsic functional connectivity (iFC) provides a means to investigate the functional architecture of the brain, unbiased by task demands. Using ultra-high field neuroimaging (7-Tesla fMRI), which provides increased spatial resolution, this study compared the iFC networks of the CeA and BNST in 27 healthy individuals. Both structures were coupled with areas of the medial prefrontal cortex, hippocampus, thalamus, and periaqueductal gray matter. Compared to the BNST, the bilateral CeA was more strongly coupled with the insula and regions that support sensory processing, including thalamus and fusiform gyrus. In contrast, the bilateral BNST was more strongly coupled with regions involved in cognitive and motivational processes, including the dorsal paracingulate gyrus, posterior cingulate cortex, and striatum. Collectively, these findings suggest that responses to sensory stimulation are preferentially coordinated by the CeA and cognitive and motivational responses are preferentially coordinated by the BNST.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.