Evidence map›Paper›PMID 28392344›Full record

ArticleThe Journal of investigative dermatology2017

After Skin Wounding, Noncoding dsRNA Coordinates Prostaglandins and Wnts to Promote Regeneration.

Amadeus S Zhu, Ang Li, Tabetha S Ratliff, Martha Melsom, Luis A Garza

Abstract read
In one paragraph

Article in The Journal of investigative dermatology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
4.1field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 36 citations in OpenAlex.

  1. Astrocytic Ryk signaling coordinates scarring and wound healing after spinal cord injury.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Review
  7. Article
  8. Toward Understanding Wound Immunology for High-Fidelity Skin Regeneration.Cold Spring Harbor perspectives in biology · 2022
    Review
  9. Neutrophil extracellular traps impair regeneration.Journal of cellular and molecular medicine · 2021
    Article
  10. [Metabolism and transport pathway of prostaglandin E2 and its role in liver regeneration].Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology · 2021
    Review
  11. Endogenous Double-Stranded RNA.Non-coding RNA · 2021
    Review
  12. Article
  13. Review
  14. Review
  15. Review
  16. In Utero and Lactational Exposure to Flame Retardants Disrupts Rat Ovarian Follicular Development and Advances Puberty.Toxicological sciences : an official journal of the Society of Toxicology · 2020
    Article
  17. Review
  18. [Wound-induced hair follicle neogenesis: a new perspective on hair follicles regeneration in adult mammals].Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2020
    Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Amadeus S ZhuDepartment of Dermatology, Johns Hopkins School of Medicine, Baltimore, Maryland, USA.
Ang LiDepartment of Dermatology, Johns Hopkins School of Medicine, Baltimore, Maryland, USA.
Tabetha S RatliffDepartment of Dermatology, Johns Hopkins School of Medicine, Baltimore, Maryland, USA.
Martha MelsomDepartment of Biology, Johns Hopkins University, Baltimore, Maryland, USA.
Luis A GarzaDepartment of Dermatology, Johns Hopkins School of Medicine, Baltimore, Maryland, USA. Electronic address: LAG@jhmi.edu.
Johns Hopkins University · US

Funding

Mechanism and clinical pilot tst of volar fibroblast to create ectopic volar skinR01AR064297 · NIAMS · JOHNS HOPKINS UNIVERSITY · PI GARZA, LUIS ANDRES · 2013 to 2017
$1.8M
Towards the clinical testing of dsRNA to promote wound induced hair neogenesisR01AR068280 · NIAMS · JOHNS HOPKINS UNIVERSITY · PI GARZA, LUIS ANDRES · 2016 to 2018
$718k
NIAMS NIH HHS R01 AR064297NIAMS NIH HHS R01 AR068280
6 · The paper itself

Abstract

In a rare example akin to organogenesis in adult mammals, large wounds in mice lead to de novo morphogenesis of hair follicles. It is still not fully clear what controls this process, known as wound-induced hair neogenesis (WIHN). In other tissues, prostaglandin E

Indexed as

Gene Expression RegulationRegenerationAnimalsCells, CulturedDisease Models, AnimalImmunoblottingMice, Inbred C57BLProstaglandinsProto-Oncogene ProteinsReverse Transcriptase Polymerase Chain ReactionRNA, Double-StrandedSkinWnt ProteinsWnt Signaling PathwayWound HealingWounds and InjuriesProstaglandinsProto-Oncogene ProteinsRNA, Double-StrandedWnt7b protein, mouseWnt Proteins

Identifiers

PMID28392344
PMCPMC5483387
OpenAlexW2604615792

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.