Evidence map›Paper›PMID 28392269›Full record

ArticleFitoterapia2017

Chemotaxonomic and biosynthetic relationships between flavonolignans produced by Silybum marianum populations.

Sameh F AbouZid, Hayam S Ahmed, Abeer S Moawad, Asmaa I Owis, Shao-Nong Chen, Amandine Nachtergael, James B McAlpine, J Brent Friesen, Guido F Pauli

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Fitoterapia, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 21 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Sameh F AbouZidDepartment of Pharmacognosy, Faculty of Pharmacy, Beni-Suef University, Beni-Suef 62111, Egypt. Electronic address: sameh.zaid@pharm.bsu.edu.eg.
Hayam S AhmedDepartment of Pharmacognosy, Faculty of Pharmacy, Beni-Suef University, Beni-Suef 62111, Egypt.
Abeer S MoawadDepartment of Pharmacognosy, Faculty of Pharmacy, Beni-Suef University, Beni-Suef 62111, Egypt.
Asmaa I OwisDepartment of Pharmacognosy, Faculty of Pharmacy, Beni-Suef University, Beni-Suef 62111, Egypt.
Shao-Nong ChenUIC/NIH Center for Botanical Dietary Supplements Research, College of Pharmacy, University of Illinois at Chicago, 833 S. Wood St., M/C 781, Chicago, IL 60612, United States; Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, 833 S. Wood St., M/C 781, Chicago, IL 60612, United States.
Amandine NachtergaelDepartment of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, 833 S. Wood St., M/C 781, Chicago, IL 60612, United States.
James B McAlpineDepartment of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, 833 S. Wood St., M/C 781, Chicago, IL 60612, United States.
J Brent FriesenDepartment of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, 833 S. Wood St., M/C 781, Chicago, IL 60612, United States; Physical Sciences Department, Rosary College of Arts and Sciences, Dominican University, 7900 West Division Street, River Forest, IL 60305, United States.
Guido F PauliUIC/NIH Center for Botanical Dietary Supplements Research, College of Pharmacy, University of Illinois at Chicago, 833 S. Wood St., M/C 781, Chicago, IL 60612, United States; Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, 833 S. Wood St., M/C 781, Chicago, IL 60612, United States.
Beni-Suef University · EGUniversity of Illinois Chicago · USDominican University · US

Funding

Van Breemen: Project 3; Botanical Dietary Supplements - Metabolism and Safety in Women (Van Breemen)P50AT000155 · NCCIH · UNIVERSITY OF ILLINOIS AT CHICAGO · PI PAULI, GUIDO F · 1999 to 2019
$30.4M
NCCIH NIH HHS P50 AT000155
6 · The paper itself

Abstract

Flavonolignans constitute an important class of plant secondary metabolites formed by oxidative coupling of one flavonoid and one phenylpropanoid moiety. The standardized flavonolignan-rich extract prepared from the fruits of Silybum marianum is known as silymarin and has long been used medicinally, prominently as an antihepatotoxic and as a chemopreventive agent. Principal component analysis of the variation in flavonolignan content in S. marianum samples collected from different locations in Egypt revealed biosynthetic relationships between the flavonolignans. Silybin A, silybin B, and silychristin are positively correlated as are silydianin, isosilychristin, and isosilybin B. The detection of silyamandin in the extracts of S. marianum correlates with isosilychristin and silydianin content. The positive correlation between silydianin, isosilychristin, and silyamandin was demonstrated using quantitative

Indexed as

EgyptFlavonolignansFruitMolecular StructureSecondary MetabolismSilybinSilybum marianumSilymarinFlavonolignansisosilybin AsilidianinsilyamandinSilybinsilychristinSilymarinBiosynthesisFlavonolignansPrincipal component analysisqHNMRSilybum marianum

Identifiers

PMID28392269
PMCPMC5532885
OpenAlexW2604516889

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.