Evidence map›Paper›PMID 28392258›Full record

ArticleStructure (London, England : 1993)2017

Bilayer-Mediated Structural Transitions Control Mechanosensitivity of the TREK-2 K2P Channel.

Prafulla Aryal, Viwan Jarerattanachat, Michael V Clausen, Marcus Schewe, Conor McClenaghan, Liam Argent, Linus J Conrad, Yin Y Dong, Ashley C W Pike, Elisabeth P Carpenter and 3 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Structure (London, England : 1993), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed
3.8field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

46 citing papers in PubMed, 85 citations in OpenAlex.

  1. Article
  2. Lipid Regulation of Mechanosensitive Ion Channels.International journal of molecular sciences · 2026
    Review
  3. Article
  4. Journal of chemical theory and computation · 2025
    Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Piezo1 ion channels are capable of conformational signaling.bioRxiv : the preprint server for biology · 2024
    Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. The energetics of rapid cellular mechanotransduction.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  15. Review
  16. Physics of mechanotransduction by Piezo ion channels.The Journal of general physiology · 2022
    Review
  17. Article
  18. Structural Basis for pH-gating of the KNature communications · 2022
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 2 countries.

Prafulla AryalClarendon Laboratory, Department of Physics, University of Oxford, Oxford OX1 3PU, UK; Department of Biochemistry, University of Oxford, Oxford OX1 3QU, UK; OXION Initiative in Ion Channels and Disease, University of Oxford, Oxford OX1 3PT, UK.
Viwan JarerattanachatClarendon Laboratory, Department of Physics, University of Oxford, Oxford OX1 3PU, UK; Department of Biochemistry, University of Oxford, Oxford OX1 3QU, UK.
Michael V ClausenClarendon Laboratory, Department of Physics, University of Oxford, Oxford OX1 3PU, UK.
Marcus ScheweDepartment of Physiology, University of Kiel, 24118 Kiel, Germany.
Conor McClenaghanClarendon Laboratory, Department of Physics, University of Oxford, Oxford OX1 3PU, UK; OXION Initiative in Ion Channels and Disease, University of Oxford, Oxford OX1 3PT, UK.
Liam ArgentDepartment of Biochemistry, University of Oxford, Oxford OX1 3QU, UK; OXION Initiative in Ion Channels and Disease, University of Oxford, Oxford OX1 3PT, UK.
Linus J ConradClarendon Laboratory, Department of Physics, University of Oxford, Oxford OX1 3PU, UK; OXION Initiative in Ion Channels and Disease, University of Oxford, Oxford OX1 3PT, UK.
Yin Y DongStructural Genomics Consortium, University of Oxford, Oxford OX3 7DQ, UK.
Ashley C W PikeStructural Genomics Consortium, University of Oxford, Oxford OX3 7DQ, UK.
Elisabeth P CarpenterOXION Initiative in Ion Channels and Disease, University of Oxford, Oxford OX1 3PT, UK; Structural Genomics Consortium, University of Oxford, Oxford OX3 7DQ, UK.
Thomas BaukrowitzDepartment of Physiology, University of Kiel, 24118 Kiel, Germany.
Mark S P SansomDepartment of Biochemistry, University of Oxford, Oxford OX1 3QU, UK; OXION Initiative in Ion Channels and Disease, University of Oxford, Oxford OX1 3PT, UK. Electronic address: mark.sansom@bioch.ox.ac.uk.
Stephen J TuckerClarendon Laboratory, Department of Physics, University of Oxford, Oxford OX1 3PU, UK; OXION Initiative in Ion Channels and Disease, University of Oxford, Oxford OX1 3PT, UK. Electronic address: stephen.tucker@physics.ox.ac.uk.
University of Oxford · GBGenomics (United Kingdom) · GBKiel University · DE

Funding

Biotechnology and Biological Sciences Research CouncilWellcome Trust
6 · The paper itself

Abstract

The mechanosensitive two-pore domain (K2P) K

Indexed as

Ion Channel GatingHumansLipid BilayersMechanotransduction, CellularPotassium Channels, Tandem Pore DomainKCNK10 protein, humanLipid BilayersPotassium Channels, Tandem Pore DomainK2P channelK(+) channel gatingKCNK10KCNK2KCNK4MechanosensitiveTREK-2

Identifiers

PMID28392258
PMCPMC5415359
OpenAlexW2604628994

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.