ArticleJournal of theoretical biology2017
On the origin of non-membrane-bound organelles, and their physiological function.
Article in Journal of theoretical biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 43 citations in OpenAlex.
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- Vital for Viruses: Intrinsically Disordered Proteins.Journal of molecular biology · 2023Review
- Mechanism of Phase Separation in Aqueous Two-Phase Systems.International journal of molecular sciences · 2022Article
- The perinuclear region concentrates disordered proteins with predicted phase separation distributed in a 3D network of cytoskeletal filaments and organelles.Biochimica et biophysica acta. Molecular cell research · 2022Article
- Role of Liquid-Liquid Separation in Endocrine and Living Cells.Journal of the Endocrine Society · 2021Review
- Dynamic colocalization of 2 simultaneously activeProceedings of the National Academy of Sciences of the United States of America · 2019Article
- The Rational Discovery of a Tau Aggregation Inhibitor.Biochemistry · 2018Article
- Do Cellular Condensates Accelerate Biochemical Reactions? Lessons from Microdroplet Chemistry.Biophysical journal · 2018Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The origin of cellular compartmentalization has long been viewed as paralleling the origin of life. Historically, membrane-bound organelles have been presented as the canonical examples of compartmentalization. However, recent interest in cellular compartments that lack encompassing membranes has forced biologists to reexamine the form and function of cellular organization. The intracellular environment is now known to be full of transient macromolecular structures that are essential to cellular function, especially in relation to RNA regulation. Here we discuss key findings regarding the physicochemical principles governing the formation and function of non-membrane-bound organelles. Particularly, we focus how the physiological function of non-membrane-bound organelles depends on their molecular structure. We also present a potential mechanism for the formation of non-membrane-bound organelles. We conclude with suggestions for future inquiry into the diversity of roles played by non-membrane bound organelles.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.