ArticleDiabetes & metabolism2017
Associations between a fetal imprinted gene allele score and late pregnancy maternal glucose concentrations.
Article in Diabetes & metabolism, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 28 citations in OpenAlex.
- Maternal and offspring genome-wide association study of C-reactive protein reveals limited polygenic association with gestational diabetes mellitus.BMC genomics · 2026Article
- Deciphering signaling mechanisms and developmental dynamics in extraembryonic mesoderm specification from hESCs.Nature communications · 2025Article
- Influence of gestational diabetes mellitus on the cardiovascular system and its underlying mechanisms.Frontiers in endocrinology · 2025Review
- Exercise therapy for gestational diabetes mellitus: from basic to clinical.Frontiers in medicine · 2025Review
- Fetal manipulation of maternal metabolism is a critical function of the imprinted Igf2 gene.Cell metabolism · 2023Article
- Multigenerational diabetes mellitus.Frontiers in endocrinology · 2023Review
- Dietary Impacts on Gestational Diabetes: Connection between Gut Microbiome and Epigenetic Mechanisms.Nutrients · 2022Review
- Increased basal insulin sensitivity in late pregnancy in women carrying a male fetus: a cohort study.Biology of sex differences · 2022Article
- Extensive Study of Breast Milk and Infant Growth: Protocol of the Cambridge Baby Growth and Breastfeeding Study (CBGS-BF).Nutrients · 2021Article
- Pregnancy Serum DLK1 Concentrations Are Associated With Indices of Insulin Resistance and Secretion.The Journal of clinical endocrinology and metabolism · 2021Article
- Folic acid supplementation during pregnancy and associations with offspring size at birth and adiposity: a cohort study.BMC research notes · 2021Article
- Observational
- Bi-stream CNN Down Syndrome screening model based on genotyping array.BMC medical genomics · 2018Article
- The influence of maternal pregnancy glucose concentrations on associations between a fetal imprinted gene allele score and offspring size at birth.BMC research notes · 2018Article
- Paternal developmental toxicant exposure is associated with epigenetic modulation of sperm and placental Pgr and Igf2 in a mouse model.Biology of reproduction · 2018Article
- Associations between the maternal circulating lipid profile in pregnancy and fetal imprinted gene alleles: a cohort study.Reproductive biology and endocrinology : RB&E · 2018Article
- The association between age at menarche and later risk of gestational diabetes is mediated by insulin resistance.Acta diabetologica · 2018Article
- Ethnic Disparities in Gestational Diabetes.Current diabetes reports · 2018Review
- Vomiting in pregnancy is associated with a higher risk of low birth weight: a cohort study.BMC pregnancy and childbirth · 2018Article
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Authors and funding
11 authors at 4 institutions in 2 countries.
Funding
Abstract
aimWe hypothesised that some of the genetic risk for gestational diabetes (GDM) is due to the fetal genome affecting maternal glucose concentrations. Previously, we found associations between fetal IGF2 gene variants and maternal glucose concentrations in late pregnancy.
methodsIn the present study, we tested associations between SNP alleles from 15 fetal imprinted genes and maternal glucose concentrations in late pregnancy in the Cambridge Baby Growth and Wellbeing cohorts (1160 DNA trios).
resultsFour fetal SNP alleles with the strongest univariate associations: paternally-transmitted IGF2 rs10770125 (P-value=2×10
conclusionThis study suggests that polymorphic variation in fetal imprinted genes, particularly in the IGF2/INS region, contribute a small but significant part to the risk of raised late pregnancy maternal glucose concentrations.
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Registered trials
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