Evidence map›Paper›PMID 28392151›Full record

ArticleEuropean neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology2017

Effects of risk for bipolar disorder on brain function: A twin and family study.

Genichi Sugihara, Fergus Kane, Marco M Picchioni, Christopher A Chaddock, Eugenia Kravariti, Sridevi Kalidindi, Fruhling Rijsdijk, Timothea Toulopoulou, Vivienne A Curtis, Colm McDonald and 2 more

Open access · hybridAbstract readTwin Study
PubMed Full text at PMC Publisher
In one paragraph

Article in European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 7 citations in OpenAlex.

  1. The Risk for Schizophrenia-Bipolar Spectrum: Does the Apple Fall Close to the Tree? A Narrative Review.International journal of environmental research and public health · 2023
    Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 2 countries.

Genichi SugiharaInstitute of Psychiatry, Psychology & Neuroscience, King׳s College London, De Crespigny Park, SE5 8AF, UK. Electronic address: genichi.sugihara@kcl.ac.uk.
Fergus KaneInstitute of Psychiatry, Psychology & Neuroscience, King׳s College London, De Crespigny Park, SE5 8AF, UK.
Marco M PicchioniInstitute of Psychiatry, Psychology & Neuroscience, King׳s College London, De Crespigny Park, SE5 8AF, UK; St Andrew׳s Academic Centre, King׳s College London, NN1 5BG, UK.
Christopher A ChaddockInstitute of Psychiatry, Psychology & Neuroscience, King׳s College London, De Crespigny Park, SE5 8AF, UK.
Eugenia KravaritiInstitute of Psychiatry, Psychology & Neuroscience, King׳s College London, De Crespigny Park, SE5 8AF, UK.
Sridevi KalidindiInstitute of Psychiatry, Psychology & Neuroscience, King׳s College London, De Crespigny Park, SE5 8AF, UK.
Fruhling RijsdijkInstitute of Psychiatry, Psychology & Neuroscience, King׳s College London, De Crespigny Park, SE5 8AF, UK.
Timothea ToulopoulouInstitute of Psychiatry, Psychology & Neuroscience, King׳s College London, De Crespigny Park, SE5 8AF, UK.
Vivienne A CurtisInstitute of Psychiatry, Psychology & Neuroscience, King׳s College London, De Crespigny Park, SE5 8AF, UK.
Colm McDonaldDepartment of Psychiatry, Clinical Science Institute, National University of Ireland, Galway, University Road, Galway, Ireland.
Robin M MurrayInstitute of Psychiatry, Psychology & Neuroscience, King׳s College London, De Crespigny Park, SE5 8AF, UK.
Philip McGuireInstitute of Psychiatry, Psychology & Neuroscience, King׳s College London, De Crespigny Park, SE5 8AF, UK.
King's College London · GBOllscoil na Gaillimhe – University of Galway · IE

Funding

Department of Health RP-PG-0606-1049Medical Research Council G0600972Medical Research Council G0700995Medical Research Council G1100583Medical Research Council MR/K004867/1Medical Research Council MR/K013807/1Medical Research Council MR/N026063/1Wellcome Trust
6 · The paper itself

Abstract

Bipolar disorder (BPD) is associated with altered regional brain function during the performance of cognitive tasks. The relative contribution of genetic and environmental risk factors for BPD to these changes has not yet been quantified. We sought to address this issue in a functional neuroimaging study of people who varied in their risk for BPD. Functional magnetic resonance imaging was used to study 124 subjects (29 twin and 9 sibling pairs with at least one member with BPD, and 24 healthy twin pairs) performing a working memory task. We assessed the influence of risk for BPD on regional brain function during the task in a two stage process. Firstly, we identified areas where there were group differences in activation. Secondly, we estimated the heritability and phenotypic correlation of activation and BPD using genetic modeling. BPD was associated with increased activation in the anterior cingulate, orbitofrontal, medial prefrontal, and left precentral cortices, and in the precuneus. Within these regions, activation in the orbitofrontal cortex rendered the most significant heritability estimate (h

Indexed as

Diseases in TwinsFamily HealthAdultBipolar DisorderBrainFemaleGene-Environment InteractionHumansImage Processing, Computer-AssistedMagnetic Resonance ImagingMaleMiddle AgedOxygenPsychiatric Status Rating ScalesRisk FactorsTwinsOxygenBipolar disorderFunctional magnetic resonance imagingGenetic modelingTwinWorking memory

Identifiers

PMID28392151
PMCPMC5446324
OpenAlexW2604676757

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.