ArticleCurrent biology : CB2017
A Descending Neuron Correlated with the Rapid Steering Maneuvers of Flying Drosophila.
Article in Current biology : CB, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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Who cites it
42 citing papers in PubMed.
- Central complex representations of self-movement are sufficient to compute wind direction in flight.Science advances · 2026Article
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- Drosophila DNp03 descending neurons serve as a hub within a flight saccade network.Current biology : CB · 2026Article
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- Specialized parallel pathways for adaptive control of visual object pursuit.bioRxiv : the preprint server for biology · 2025Article
- Single-cell type analysis of wing premotor circuits in the ventral nerve cord ofbioRxiv : the preprint server for biology · 2025Article
- Article
- Bilateral interactions of optic-flow sensitive neurons coordinate course control in flies.Nature communications · 2024Article
- Flies tune the activity of their multifunctional gyroscope.Current biology : CB · 2024Article
- Article
- Asynchronous haltere input drives specific wing and head movements inProceedings. Biological sciences · 2024Article
- Synaptic architecture of leg and wing premotor control networks inbioRxiv : the preprint server for biology · 2024Article
- Morphology and synapse topography optimize linear encoding of synapse numbers inbioRxiv : the preprint server for biology · 2024Article
- Descending control and regulation of spontaneous flight turns in Drosophila.Current biology : CB · 2024Article
- Descending control of motor sequences in Drosophila.Current opinion in neurobiology · 2024Review
- Finding the gap: neuromorphic motion-vision in dense environments.Nature communications · 2024Article
- The influence of saccades on yaw gaze stabilization in fly flight.PLoS computational biology · 2023Article
- Fine-grained descending control of steering in walkingbioRxiv : the preprint server for biology · 2023Article
- Article
- Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
To navigate through the world, animals must stabilize their path against disturbances and change direction to avoid obstacles and to search for resources [1, 2]. Locomotion is thus guided by sensory cues but also depends on intrinsic processes, such as motivation and physiological state. Flies, for example, turn with the direction of large-field rotatory motion, an optomotor reflex that is thought to help them fly straight [3-5]. Occasionally, however, they execute fast turns, called body saccades, either spontaneously or in response to patterns of visual motion such as expansion [6-8]. These turns can be measured in tethered flying Drosophila [3, 4, 9], which facilitates the study of underlying neural mechanisms. Whereas there is evidence for an efference copy input to visual interneurons during saccades [10], the circuits that control spontaneous and visually elicited saccades are not well known. Using two-photon calcium imaging and electrophysiological recordings in tethered flying Drosophila, we have identified a descending neuron whose activity is correlated with both spontaneous and visually elicited turns during tethered flight. The cell's activity in open- and closed-loop experiments suggests that it does not underlie slower compensatory responses to horizontal motion but rather controls rapid changes in flight path. The activity of this neuron can explain some of the behavioral variability observed in response to visual motion and appears sufficient for eliciting turns when artificially activated. This work provides an entry point into studying the circuits underlying the control of rapid steering maneuvers in the fly brain.
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