Evidence map›Paper›PMID 28392013›Full record

ReviewPlacenta2017

Characterizing the lipid and metabolite changes associated with placental function and pregnancy complications using ion mobility spectrometry-mass spectrometry and mass spectrometry imaging.

Kristin E Burnum-Johnson, Erin S Baker, Thomas O Metz

Open access · greenAbstract readReview
In one paragraph

Review in Placenta, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
3.6field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 26 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Regulation of maternal-fetal metabolic communication.Cellular and molecular life sciences : CMLS · 2021
    Review
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Kristin E Burnum-JohnsonBiological Sciences Division, Pacific Northwest National Laboratory, Richland, WA, USA.
Erin S BakerBiological Sciences Division, Pacific Northwest National Laboratory, Richland, WA, USA. Electronic address: erin.baker@pnnl.gov.
Thomas O MetzBiological Sciences Division, Pacific Northwest National Laboratory, Richland, WA, USA. Electronic address: thomas.metz@pnnl.gov.
Pacific Northwest National Laboratory · US

Funding

Platform Providing Increased Throughput, Sensitivity and Specificity for MetaboloR01ES022190 · NIEHS · BATTELLE PACIFIC NORTHWEST LABORATORIES · PI BAKER, ERIN S · 2012 to 2016
$2.2M
Pan-omic characterization of the molecular determinants of uterine receptivityR21HD084788 · NICHD · BATTELLE PACIFIC NORTHWEST LABORATORIES · PI BURNUM-JOHNSON, KRISTIN · 2016 to 2017
$509k
NICHD NIH HHS R21 HD084788NIEHS NIH HHS R01 ES022190
6 · The paper itself

Abstract

Successful pregnancy is dependent upon discrete biological events, which include embryo implantation, decidualization, and placentation. Problems associated with each of these events can cause infertility or conditions such as preeclampsia. A greater understanding of the molecular changes associated with these complex processes is necessary to aid in identifying treatments for each condition. Previous nuclear magnetic resonance spectroscopy and mass spectrometry studies have been used to identify metabolites and lipids associated with pregnancy-related complications. However, due to limitations associated with conventional implementations of both techniques, novel technology developments are needed to more fully understand the initiation and development of pregnancy related problems at the molecular level. In this perspective, we describe current analytical techniques for metabolomic and lipidomic characterization of pregnancy complications and discuss the potential for new technologies such as ion mobility spectrometry-mass spectrometry and mass spectrometry imaging to contribute to a better understanding of the molecular changes that affect the placenta and pregnancy outcomes.

Indexed as

Lipid MetabolismModels, BiologicalAnimalsChromatography, High Pressure LiquidEmbryo ImplantationFemaleHumansIon Mobility SpectrometryMetabolomicsPlacentaPlacentationPregnancyPregnancy ComplicationsSpectrometry, Mass, Electrospray IonizationSpectrometry, Mass, Secondary IonDeep placentationIon mobility spectrometry-mass spectrometryLipidomeMass spectrometry imagingMetabolomeNano-DESIPregnancy complications

Identifiers

PMID28392013
PMCPMC5620120
OpenAlexW2603458739

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.