Evidence map›Paper›PMID 28391893›Full record

ArticleJournal of clinical lipidology

Red blood cell polyunsaturated fatty acids and mortality in the Women's Health Initiative Memory Study.

William S Harris, Juhua Luo, James V Pottala, Mark A Espeland, Karen L Margolis, Joann E Manson, Lu Wang, Theodore M Brasky, Jennifer G Robinson

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PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical lipidology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 4 pooled it
4.8field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 4 syntheses or guidelines pooled it, 74 citations in OpenAlex.

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  13. Omega-3 fatty acids in heart disease-why accurately measured levels matter.Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 7 institutions in 1 country.

William S HarrisDepartment of Internal Medicine, Sanford School of Medicine, University of South Dakota, Sioux Falls, SD, USA; OmegaQuant Analytics, LLC, Sioux Falls, SD, USA. Electronic address: bill@omegaquant.com.
Juhua LuoDepartment of Epidemiology and Biostatistics, School of Public Health, Indiana University, Bloomington, IN, USA.
James V PottalaDepartment of Internal Medicine, Sanford School of Medicine, University of South Dakota, Sioux Falls, SD, USA.
Mark A EspelandDepartment of Biostatistical Sciences, Wake Forest School of Medicine, Winston-Salem, NC, USA.
Karen L MargolisHealthPartners Institute, Minneapolis, MN, USA.
Joann E MansonBrigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Lu WangBrigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Theodore M BraskyComprehensive Cancer Center, Ohio State University, Columbus, OH, USA.
Jennifer G RobinsonDepartment of Epidemiology, College of Public Health and Department of Internal Medicine, College of Medicine, University of Iowa, Iowa City, IA, USA.
Brigham and Women's Hospital · USUniversity of South Dakota · USHealthPartners · USIndiana University Bloomington · USThe Ohio State University · USUniversity of Iowa · USWake Forest University · US

Funding

WHI NIH HHS HHSN268200900036C
6 · The paper itself

Abstract

backgroundThe prognostic value of circulating polyunsaturated fatty acid (PUFA) levels is unclear.

objectivesTo determine the associations between red blood cell (RBC) PUFA levels and risk for death.

methodsThis prospective cohort study included 6501 women aged 65 to 80 years who participated in the Women's Health Initiative Memory Study (enrolment began 1996). RBC PUFA levels were measured at baseline and expressed as a percent of total RBC PUFAs. PUFAs of primary interest were the n-3 PUFAs eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) and their sum (the Omega-3 Index). PUFAs of secondary interest included the 2 major n-6 PUFAs, linoleic acid and arachidonic acid, and the PUFA factor score (a calculated variable including 6 PUFAs that accounts for their intercorrelations). The primary outcome was total mortality through August 2014.

resultsAfter a median of 14.9 years of follow-up, 1851 women (28.5%) had died. RBC levels of EPA and DHA were higher in the survivors (P < .002 for each). In the fully adjusted models, the hazard ratios (99% confidence intervals) for mortality associated with a 1 standard deviation PUFA increase for total mortality were 0.92 (0.85, 0.98) for the Omega-3 Index, 0.89 (0.82, 0.96) for EPA, 0.93 (0.87, 1.0) for DHA, and 0.76 (0.64, 0.90) for the PUFA factor score. There were no significant associations of alpha-linolenic acid, arachidonic acid or linoleic acid with total mortality.

conclusionsHigher RBC levels of marine n-3 PUFAs were associated with reduced risk for all-cause mortality. These findings support the beneficial relationship between the Omega-3 Index and health outcomes.

Indexed as

MortalityWomen's HealthAgedAged, 80 and overCohort StudiesErythrocytesFatty Acids, UnsaturatedFemaleHumansFatty Acids, UnsaturatedDocosahexaenoic acidEicosapentaenoic acidEpidemiologyOmega-3 fatty acidsOmega-6 fatty acidsProspective cohort study

Identifiers

PMID28391893
PMCPMC5563382
OpenAlexW2575322336

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.