Evidence map›Paper›PMID 28391531›Full record

Trial reportEuropean archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery2017

Efficacy of steroid therapy based on symptomatic and functional improvement in patients with vestibular neuritis: a prospective randomized controlled trial.

Myung Hoon Yoo, Chan Joo Yang, Shin Ae Kim, Marn Joon Park, Joong Ho Ahn, Jong Woo Chung, Hong Ju Park

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02098330 (The Efficacy of Steroid Therapy in Vestibular Neuritis Confirmed by Head Impulse Test), which is not on this map. Cited by 13 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 2 pooled it
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02098330 phase3completednot on this map

The Efficacy of Steroid Therapy in Vestibular Neuritis Confirmed by Head Impulse Test: Prospective Randomized Controlled Study

TypeinterventionalSponsorAsan Medical CenterRan2014 to 2015Enrolled40ConditionsVestibular NeuritisArmsGinkgo biloba & Methylprednisolone, Ginkgo biloba
3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 2 syntheses or guidelines pooled it, 43 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Corticosteroids versus vestibular rehabilitation in long-term outcomes in vestibular neuritis.Journal of vestibular research : equilibrium & orientation · 2018
    Trial
  5. Review
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Effect of the novel histamine HBritish journal of pharmacology · 2020
    Article
  12. Article
  13. Dizziness handicap and clinical characteristics of posterior and lateral canal BPPV.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2019
    Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Myung Hoon YooDepartment of Otorhinolaryngology-Head and Neck Surgery, College of Medicine, Kyungpook National University, Daegu, South Korea.
Chan Joo YangDepartment of Otolaryngology, Hanil General Hospital, Seoul, South Korea.
Shin Ae KimDepartment of Otolaryngology, Asan Medical Center, University of Ulsan, College of Medicine, 88 Olympicro-43-gil, Songpa-gu, Seoul, 138-736, South Korea.
Marn Joon ParkDepartment of Otolaryngology, Asan Medical Center, University of Ulsan, College of Medicine, 88 Olympicro-43-gil, Songpa-gu, Seoul, 138-736, South Korea.
Joong Ho AhnDepartment of Otolaryngology, Asan Medical Center, University of Ulsan, College of Medicine, 88 Olympicro-43-gil, Songpa-gu, Seoul, 138-736, South Korea.
Jong Woo ChungDepartment of Otolaryngology, Asan Medical Center, University of Ulsan, College of Medicine, 88 Olympicro-43-gil, Songpa-gu, Seoul, 138-736, South Korea.
Hong Ju ParkDepartment of Otolaryngology, Asan Medical Center, University of Ulsan, College of Medicine, 88 Olympicro-43-gil, Songpa-gu, Seoul, 138-736, South Korea. dzness@amc.seoul.kr.
Asan Medical Center · KRHanil General Hospital · KRKyungpook National University · KRUniversity of Ulsan · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The aim of this study was to examine the efficacy of methylprednisolone in vestibular neuritis (VN) by objective and subjective measures. This prospective controlled randomized study was conducted at one tertiary hospital. Twenty-nine VN patients were randomized to either the steroid (n = 15) or the control (n = 14) group. The steroid group received methylprednisolone for 2 weeks, whereas control patients did not; both groups underwent regular vestibular exercises and were prescribed a Ginkgo biloba. Vestibular function tests including caloric test, video head impulse test (vHIT), and sensory organization test (SOT) were performed, and dizziness handicap index (DHI) was determined at enrollment; all tests were repeated at 1 and 6 months after enrollment. Both groups showed statistically significant improvements in caloric weakness and vHIT gain at 1- and 6-month follow-up evaluations compared to the initial examination; however, differences were not significant. The rates of normalization of canal paresis at 1 and 6 months were 50 and 64% in the control group and 33 and 60% in the steroid group, respectively, with no differences between the two groups. The rates of vHIT normalization at 1 and 6 months after treatment were 57 and 78% in the control group and 53 and 87% in the steroid group, respectively, with no differences between the two groups. Finally, there were no significant differences in the improvement of composite scores of SOT and the DHI scores between the two groups. In this prospective RCT, methylprednisolone had no additional benefit in patients with VN who underwent vestibular exercises and received a Ginkgo biloba.

trial registrationClinicaltrials.gov Identifier, NCT02098330; Trial title, The Efficacy of Steroid Therapy in Vestibular Neuritis.

Indexed as

VertigoVestibular NeuronitisAdultAgedCaloric TestsDrug MonitoringFemaleGlucocorticoidsHead Impulse TestHumansMaleMethylprednisoloneMiddle AgedProspective StudiesTreatment OutcomeVestibule, LabyrinthGlucocorticoidsMethylprednisoloneCaloric testHead impulse testMethylprednisoloneSteroidVertigoVestibular neuritis

Identifiers

PMID28391531
OpenAlexW2605183658

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.