Evidence map›Paper›PMID 28391526›Full record

ArticleHuman genetics2017

Trans-ethnic fine-mapping of genetic loci for body mass index in the diverse ancestral populations of the Population Architecture using Genomics and Epidemiology (PAGE) Study reveals evidence for multiple signals at established loci.

Lindsay Fernández-Rhodes, Jian Gong, Jeffrey Haessler, Nora Franceschini, Mariaelisa Graff, Katherine K Nishimura, Yujie Wang, Heather M Highland, Sachiko Yoneyama, William S Bush and 56 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Human genetics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
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  18. Genetics of Obesity in East Asians.Frontiers in genetics · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

66 authors.

Lindsay Fernández-RhodesDepartment of Epidemiology, UNC Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. fernandez-rhodes@unc.edu.ORCID 0000-0001-6985-423X
Jian GongDivision of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Jeffrey HaesslerDivision of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Nora FranceschiniDepartment of Epidemiology, UNC Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Mariaelisa GraffDepartment of Epidemiology, UNC Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Katherine K NishimuraDivision of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Yujie WangDepartment of Epidemiology, UNC Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Heather M HighlandDepartment of Epidemiology, UNC Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Sachiko YoneyamaDepartment of Epidemiology, UNC Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
William S BushDepartment of Epidemiology and Biostatistics, Institute for Computational Biology, Case Western Reserve University, Cleveland, OH, USA.
Robert GoodloeCenter for Human Genetics Research, Vanderbilt University, Nashville, TN, USA.
Marylyn D RitchieBiochemistry and Molecular Biology, The Pennsylvania State University, University Park, PA, USA.
Dana CrawfordDepartment of Epidemiology and Biostatistics, Institute for Computational Biology, Case Western Reserve University, Cleveland, OH, USA.
Myron GrossDepartment of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN, USA.
Myriam FornageCenter for Human Genetics, The University of Texas Health Science Center at Houston, Houston, TX, USA.
Petra BuzkovaDepartment of Biostatistics, School of Public Health, University of Washington, Seattle, WA, USA.
Ran TaoDepartment of Biostatistics, UNC Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Carmen IsasiDepartment of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY, USA.
Larissa Avilés-SantaNational Heart Lung, and Blood Institute, Bethesda, MA, USA.
Martha DaviglusInsitute of Minority Health Research, University of Illinois at Chicago, Chicago, IL, USA.
Rachel H MackeyDepartment of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA.
Denise HoustonGeriatrics and Gerontology, Wake Forest School of Medicine, Winston-Salem, NC, USA.
C Charles GuDivision of Biostatistics, School of Medicine, Washington University in St. Louis, St. Louis, MO, USA.
Georg EhretCenter for Complex Disease Genomics, McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University, Baltimore, MD, USA.
Khanh-Dung H NguyenCenter for Complex Disease Genomics, McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University, Baltimore, MD, USA.
Cora E LewisDepartment of Medicine, University of Alabama, Birmingham, AL, USA.
Mark LeppertDepartment of Human Genetics, University of Utah, Salt Lake City, UT, USA.
Marguerite R IrvinDepartment of Biostatistics, University of Alabama, Birmingham, AL, USA.
Unhee LimEpidemiology Program, University of Hawaii Cancer Center, Honolulu, HI, USA.
Christopher A HaimanDepartment of Preventive Medicine, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Loic Le MarchandEpidemiology Program, University of Hawaii Cancer Center, Honolulu, HI, USA.
Fredrick SchumacherDepartment of Preventive Medicine, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Lynne WilkensEpidemiology Program, University of Hawaii Cancer Center, Honolulu, HI, USA.
Yingchang LuCharles R. Bronfman Instituted for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Erwin P BottingerCharles R. Bronfman Instituted for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Ruth J L LoosCharles R. Bronfman Instituted for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Wayne H-H SheuDivision of Endocrine and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan.
Xiuqing GuoDepartment of Pediatrics, Institute for Translational Genomics and Population Sciences, LABioMed at Harbor-UCLA Medical Center, Torrance, CA, USA.
Wen-Jane LeeDepartment of Medical Research, Taichung Veterans General Hospital, Taichung, Taiwan.
Yang HaiDepartment of Pediatrics, Institute for Translational Genomics and Population Sciences, LABioMed at Harbor-UCLA Medical Center, Torrance, CA, USA.
Yi-Jen HungDivision of Endocrinology and Metabolism, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.
Devin AbsherHudsonAlpha Institute for Biotechnology, Huntsville, AL, USA.
I-Chien WuDivision of Biostatistics and Bioinformatics, Institute of Population Health Sciences, National Health Research Institutes, Zhunan Town, Taiwan.
Kent D TaylorDepartment of Pediatrics, Institute for Translational Genomics and Population Sciences, LABioMed at Harbor-UCLA Medical Center, Torrance, CA, USA.
I-Te LeeDivision of Endocrine and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan.
Yeheng LiuDepartment of Pediatrics, Institute for Translational Genomics and Population Sciences, LABioMed at Harbor-UCLA Medical Center, Torrance, CA, USA.
Tzung-Dau WangDivision of Cardiology, Department of Internal Medicine, Cardiovascular Center, National Taiwan University Hospital, Taipei, Taiwan.
Thomas QuertermousDepartment of Medicine, Stanford University School of Medicine, Stanford, CA, USA.
Jyh-Ming J JuangDivision of Cardiology, Department of Internal Medicine, Cardiovascular Center, National Taiwan University Hospital, Taipei, Taiwan.
Jerome I RotterDepartment of Pediatrics, Institute for Translational Genomics and Population Sciences, LABioMed at Harbor-UCLA Medical Center, Torrance, CA, USA.
Themistocles AssimesDepartment of Medicine, Stanford University School of Medicine, Stanford, CA, USA.
Chao A HsiungDivision of Biostatistics and Bioinformatics, Institute of Population Health Sciences, National Health Research Institutes, Zhunan Town, Taiwan.
Yii-Der Ida ChenDepartment of Pediatrics, Institute for Translational Genomics and Population Sciences, LABioMed at Harbor-UCLA Medical Center, Torrance, CA, USA.
Ross PrenticeDivision of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Lewis H KullerDepartment of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
JoAnn E MansonDivision of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, USA.
Charles KooperbergDivision of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Paul SmokowskiSchool of Social Welfare, The University of Kansas, Lawrence, KS, USA.
Whitney R RobinsonDepartment of Epidemiology, UNC Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Penny Gordon-LarsenDepartment of Nutrition, UNC Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Rongling LiDivision of Genomic Medicine, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
Lucia HindorffDivision of Genomic Medicine, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
Steven BuyskeDepartment of Statistics and Biostatistics, Rutgers University, Piscataway, NJ, USA.
Tara C MatiseDepartment of Genetics, Rutgers University, Piscataway, NJ, USA.
Ulrike PetersDivision of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Kari E NorthDepartment of Epidemiology, UNC Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

Funding

Institute for Clinical and Translational Research (UL1)UL1RR025005 · NCRR · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2007 to 2011
$75.8M
UCLA Clinical and Translational Science InstituteUL1TR000124 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DUBINETT, STEVEN M. · 2012 to 2015
$57.0M
The Vanderbilt Institute for Clinical and Translational Research (VICTR)UL1TR000445 · NCATS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BERNARD, GORDON RAPHAEL · 2012 to 2016
$41.4M
Transgenic & Knock-out MouseP30DK063491 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Andrea L Hevener · 2003 to 2026
$40.4M
Understanding Population Differences in Cancer: The MEC StudyU01CA164973 · NCI · UNIVERSITY OF HAWAII AT MANOA · PI HAIMAN, CHRISTOPHER ALAN, LE MARCHAND, LOIC · 2015 to 2025
$37.4M
UNC-CH CENTER FOR ENVIRONMENTAL HEALTH &SUSCEPTIBILITYP30ES010126 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Stephanie Engel · 2001 to 2026
$36.3M
Translational Research CoreP30DK020541 · NIDDK · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI STREAMSON C CHUA · 2015 to 2026
$27.7M
GENETIC SUSCEPTIBILITY TO CANCER IN MULTIETHNIC COHORTSR01CA063464 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI HENDERSON, BRIAN E · 2001 to 2005
$23.2M
Multiethnic Cohort Study of Diet and CancerR37CA054281 · NCI · UNIVERSITY OF HAWAII AT MANOA · PI KOLONEL, LAURENCE N. · 2003 to 2012
$23.2M
Core-010UL1TR001073 · NCATS · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI KELLER, MARLA J, SHAMOON, HARRY · 2013 to 2017
$21.3M
Genome-Wide Association Analysis in Essential Hypertension (FEHGAS study)R01HL086694 · NHLBI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI ARAVINDA CHAKRAVARTI · 2007 to 2026
$21.2M
University of Alabama at Birmingham's Diabetes Research CenterP30DK079626 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Kirk Michael Habegger · 2013 to 2026
$19.5M
NCATS NIH HHS UL1 TR000124NCATS NIH HHS UL1 TR000445NCATS NIH HHS UL1 TR001073NCI NIH HHS P01 CA033619NCI NIH HHS R01 CA054281NCI NIH HHS R01 CA063464NCI NIH HHS R25 CA094880NCI NIH HHS R37 CA054281NCI NIH HHS U01 CA098758NCI NIH HHS U01 CA136792NCI NIH HHS U01 CA164973NCI NIH HHS UM1 CA164973NCRR NIH HHS UL1 RR025005NHGRI NIH HHS U01 HG004402NHGRI NIH HHS U01 HG004790NHGRI NIH HHS U01 HG004798NHGRI NIH HHS U01 HG004801NHGRI NIH HHS U01 HG004802NHGRI NIH HHS U01 HG004803NHGRI NIH HHS U01 HG007376NHGRI NIH HHS U01 HG007397NHGRI NIH HHS U01 HG007416NHGRI NIH HHS U01 HG007417NHLBI NIH HHS HHSN268201100002INHLBI NIH HHS HHSN268201100005CNHLBI NIH HHS HHSN268201100005GNHLBI NIH HHS HHSN268201100005INHLBI NIH HHS HHSN268201100006CNHLBI NIH HHS HHSN268201100007CNHLBI NIH HHS HHSN268201100007INHLBI NIH HHS HHSN268201100008CNHLBI NIH HHS HHSN268201100008INHLBI NIH HHS HHSN268201100009CNHLBI NIH HHS HHSN268201100009INHLBI NIH HHS HHSN268201100010CNHLBI NIH HHS HHSN268201100011CNHLBI NIH HHS HHSN268201100011INHLBI NIH HHS HHSN268201100012CNHLBI NIH HHS HHSN268201200036CNHLBI NIH HHS N01 HC005187NHLBI NIH HHS N01 HC015103NHLBI NIH HHS N01 HC035129NHLBI NIH HHS N01 HC045133NHLBI NIH HHS N01 HC045134NHLBI NIH HHS N01 HC045205NHLBI NIH HHS N01 HC048047NHLBI NIH HHS N01 HC048048NHLBI NIH HHS N01 HC048049NHLBI NIH HHS N01 HC048050NHLBI NIH HHS N01 HC055222NHLBI NIH HHS N01 HC065233NHLBI NIH HHS N01 HC065234NHLBI NIH HHS N01 HC065235NHLBI NIH HHS N01 HC065236NHLBI NIH HHS N01 HC065237NHLBI NIH HHS N01 HC075150NHLBI NIH HHS N01 HC085079NHLBI NIH HHS N01 HC085086NHLBI NIH HHS N01 HC095095NHLBI NIH HHS R01 HL055673NHLBI NIH HHS R01 HL059367NHLBI NIH HHS R01 HL080295NHLBI NIH HHS R01 HL086694NHLBI NIH HHS R01 HL087641NHLBI NIH HHS T32 HL007055NHLBI NIH HHS U01 HL080295NHLBI NIH HHS U01 HL130114NIA NIH HHS R01 AG015928NIA NIH HHS R01 AG020098NIA NIH HHS R01 AG023629NIA NIH HHS R01 AG027058NIA NIH HHS R56 AG020098NIA NIH HHS R56 AG023629NICHD NIH HHS P2C HD050924NICHD NIH HHS R01 HD057194NICHD NIH HHS T32 HD007168NIDDK NIH HHS P30 DK020541NIDDK NIH HHS P30 DK063491NIDDK NIH HHS P30 DK079626NIDDK NIH HHS R01 DK089256NIDDK NIH HHS R01 DK101855NIDDK NIH HHS R01 DK110113NIEHS NIH HHS P30 ES010126NIH HHS S10 OD018522NIH HHS S10 OD020069WHI NIH HHS HHSN268201100002CWHI NIH HHS N01 WH022110
6 · The paper itself

Abstract

Most body mass index (BMI) genetic loci have been identified in studies of primarily European ancestries. The effect of these loci in other racial/ethnic groups is less clear. Thus, we aimed to characterize the generalizability of 170 established BMI variants, or their proxies, to diverse US populations and trans-ethnically fine-map 36 BMI loci using a sample of >102,000 adults of African, Hispanic/Latino, Asian, European and American Indian/Alaskan Native descent from the Population Architecture using Genomics and Epidemiology Study. We performed linear regression of the natural log of BMI (18.5-70 kg/m

Indexed as

Body Mass IndexGenetics, PopulationEthnicityHumansObesity

Identifiers

PMID28391526
PMCPMC5485655

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.