Evidence map›Paper›PMID 28391433›Full record

ArticleFamilial cancer2017

A Peutz-Jeghers syndrome family associated with sinonasal adenocarcinoma: 28 years follow up report.

Jy-Ming Chiang, Tse-Ching Chen

Abstract readCase Reports
PubMed Publisher
In one paragraph

Article in Familial cancer, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Jy-Ming ChiangDivision of Colon and Rectal Surgery, Department of Surgery, Chang Gung Memorial Hospital, Lin-Kou Medical Center, Tao-Yuan, Taiwan, Republic of China. jmjiang@adm.cgmh.org.tw.ORCID http://orcid.org/0000-0003-3700-3195
Tse-Ching ChenChang Gung Memorial Hospital, and College of Medicine, Chang Gung University, No.5, Fu-Hsing St. Kuei-Shan, Tao-Yuan, 333, Taiwan, Republic of China. ctc323@adm.cgmh.org.tw.
Chang Gung University · TW

Funding

Chang Gung Research Foundation CMRPG3D0403Chang Gung Research Foundation CMRPG3D0421, CMRPG3D0422
6 · The paper itself

Abstract

Peutz-Jeghers syndrome (PJS) is a rare hereditary disorder characterized by hamartomatous polyps in both of the gastrointestinal tract and mucosal pigmentation. It could increase in risk of intestinal and extra-intestinal neoplasms. We here described three cases of sinonasal polyposis in a PJS family and two developed sinonasal type adenocarcinoma. Genetic study revealed a germline STK11/LKB1 mutation on codon 179 (c.C536G, p.P179R) of exon 4. LOH analysis of the LKB1 locus confirms this to be a deleterious mutation. Sinonasal polyposis with malignant transformation could be encountered in PJS patients. Regular follow-up was recommended for the risk of malignant changes in nasal polyps.

Indexed as

AdenocarcinomaAdultAMP-Activated Protein Kinase KinasesFemaleHumansLoss of HeterozygosityMaleMiddle AgedNose NeoplasmsPedigreePeutz-Jeghers SyndromeProtein Serine-Threonine KinasesAMP-Activated Protein Kinase KinasesProtein Serine-Threonine KinasesSTK11 protein, humanNasal polypsPeutz-Jeghers syndromeSTK11 mutation

Identifiers

PMID28391433
OpenAlexW2604906802

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.