Evidence map›Paper›PMID 28391417›Full record

ArticleDigestive diseases and sciences2017

Differences in Phenotypes and Liver Transplantation Outcomes by Age Group in Patients with Primary Sclerosing Cholangitis.

Jacqueline B Henson, Yuval A Patel, Julius M Wilder, Jiayin Zheng, Shein-Chung Chow, Lindsay Y King, Andrew J Muir

Open access · greenAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Digestive diseases and sciences, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.7field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Sex differences in chronic liver disease and benign liver lesions.JHEP reports : innovation in hepatology · 2023
    Review
  3. Review
  4. Potential savings in the treatment pathway of liver transplantation: an inter-sectorial analysis of cost-rising factors.The European journal of health economics : HEPAC : health economics in prevention and care · 2019
    Article
  5. Article
  6. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Jacqueline B HensonDuke University School of Medicine, Durham, NC, USA.
Yuval A PatelDivision of Gastroenterology, Department of Medicine, Duke University School of Medicine, Durham, NC, USA.
Julius M WilderDivision of Gastroenterology, Department of Medicine, Duke University School of Medicine, Durham, NC, USA.
Jiayin ZhengDepartment of Biostatistics, Duke University School of Medicine, Durham, NC, USA.
Shein-Chung ChowDepartment of Biostatistics, Duke University School of Medicine, Durham, NC, USA.
Lindsay Y KingDivision of Gastroenterology, Department of Medicine, Duke University School of Medicine, Durham, NC, USA.
Andrew J MuirDivision of Gastroenterology, Department of Medicine, Duke University School of Medicine, Durham, NC, USA. andrew.muir@duke.edu.
Duke University · USClinical Research Institute · US

Funding

DUKE TRAINING GRANT IN DIGESTIVE DISEASES AND NUTRITIONT32DK007568 · NIDDK · DUKE UNIVERSITY · PI Katherine Garman, Rodger A. Liddle · 1988 to 2026
$5.6M
NIDDK NIH HHS T32 DK007568
6 · The paper itself

Abstract

backgroundThere is increasing evidence for a heterogeneity of phenotypes in primary sclerosing cholangitis (PSC), but differences across the age spectrum in adults with PSC have not been well characterized.

aimsTo characterize phenotypic variations and liver transplantation outcomes by age group in adults with PSC.

methodsThe United Network for Organ Sharing database was used to identify waitlist registrations for primary liver transplantation in adults with PSC. Patients were split into three age groups: 18-39 (young), 40-59 (middle-aged), and ≥60 (older). Their clinical characteristics and outcomes on the waitlist and post-transplant were compared.

resultsOverall, 8272 adults with PSC were listed for liver transplantation during the study period, of which 28.9% were young, 52.0% were middle-aged, and 19.1% were older. The young age group had the greatest male predominance (70.0 vs. 66.2 vs. 65.1%, p = 0.001), the highest proportion of black individuals (20.0 vs. 11.0 vs. 5.5%, p < 0.001), and the most patients listed with concomitant autoimmune hepatitis (2.2 vs. 1.0 vs. 0.8%, p < 0.001). Older patients experienced the greatest waitlist and post-transplant mortality. Graft survival was greatest in the middle-aged group. Young patients were most likely to experience acute rejection (31 vs. 22.8 vs. 18.0%, p < 0.001) and have graft failure due to chronic rejection or PSC recurrence (47.8 vs. 42.3 vs. 17.9%, p < 0.001).

conclusionsAge-related differences exist among adults with PSC and are associated with outcomes pre- and post-transplant. Young patients may have a more robust immune-related phenotype that is associated with poorer graft survival. Future studies are needed to further investigate these findings.

Indexed as

Liver TransplantationAdolescentAdultAge DistributionCholangitis, SclerosingDatabases, FactualFemaleGraft RejectionGraft SurvivalHumansKaplan-Meier EstimateMaleMiddle AgedPhenotypeRecurrenceRetrospective StudiesAge factorsLiver transplantationPhenotypeSclerosing cholangitisTreatment outcome

Identifiers

PMID28391417
PMCPMC5861350
OpenAlexW2604341092

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.