Evidence map›Paper›PMID 28391416›Full record

ArticleDigestive diseases and sciences2017

Serum Cyclophilin A Correlates with Increased Tissue MMP-9 in Patients with Ulcerative Colitis, but Not with Crohn's Disease.

Aleksandra Piechota-Polanczyk, Marcin Włodarczyk, Aleksandra Sobolewska-Włodarczyk, Mateusz Jonakowski, Andrzej Pilarczyk, Krystyna Stec-Michalska, Maria Wiśniewska-Jarosińska, Jakub Fichna

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In one paragraph

Article in Digestive diseases and sciences, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 20 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Selected Cytokines and Metalloproteinases in Inflammatory Bowel Disease.International journal of molecular sciences · 2023
    Review
  6. Review
  7. The Role of Cyclophilins in Inflammatory Bowel Disease and Colorectal Cancer.International journal of biological sciences · 2021
    Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Aleksandra Piechota-PolanczykDepartment of Biochemistry, Faculty of Medicine, Medical University of Lodz, Lodz, Poland. piechota.aleksandra@gmail.com.
Marcin WłodarczykDepartment of Biochemistry, Faculty of Medicine, Medical University of Lodz, Lodz, Poland.
Aleksandra Sobolewska-WłodarczykDepartment of Biochemistry, Faculty of Medicine, Medical University of Lodz, Lodz, Poland.
Mateusz JonakowskiDepartment of Biochemistry, Faculty of Medicine, Medical University of Lodz, Lodz, Poland.
Andrzej PilarczykDepartment of Biochemistry, Faculty of Medicine, Medical University of Lodz, Lodz, Poland.
Krystyna Stec-MichalskaDepartment of Gastroenterology, Faculty of Military Medicine, Medical University of Lodz, Lodz, Poland.
Maria Wiśniewska-JarosińskaDepartment of Gastroenterology, Faculty of Military Medicine, Medical University of Lodz, Lodz, Poland.
Jakub FichnaDepartment of Biochemistry, Faculty of Medicine, Medical University of Lodz, Lodz, Poland.
Medical University of Lodz · PL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCyclophilin A (CyPA) is an immunomodulatory protein, high expression of which correlates with poor outcome of patients with inflammatory diseases. However, its role in inflammatory bowel disease (IBD) has not been studied.

aimThis study analyzes the correlation between cyclophilin A, matrix metalloproteinase (MMP)-9, and tissue inhibitor of MMP (TIMP)/MMP-9 complexes in the inflamed and non-inflamed colon mucosa of UC and CD patients.

methodsSerum and biopsy specimens from inflamed and non-inflamed colonic mucosa of 38 patients with IBD (19 with UC and 19 with CD) and 16 controls were included in our study. We measured serum and tissue level of CyPA, and tissue level of TNF-α, MMP-9, TIMP-1/MMP-9, and TIMP-2/MMP-9 using ELISA method.

resultsOur results indicated that serum, but not tissue CyPA is increased in UC, rather than in CD patients, compared to the control. The increase correlated with higher tissue concentration of MMP-9 and TNF-α, especially in the UC group. Moreover, we observed significantly higher level of TIMP-1/MMP-9 in UC and CD group, which overlapped with the change in MMP-9. There was no change in TIMP-2/MMP-9 in the analyzed groups.

conclusionThe current study suggests that serum CyPA may be an independent additional marker of IBD, especially of UC. Higher CyPA level may be followed by increased MMP-9 in those patients. However, further studies are necessary to verify the role of CyPA in IBD development.

Indexed as

AdultBiomarkersBiopsyCase-Control StudiesColitis, UlcerativeColonCrohn DiseaseCyclophilin AFemaleHumansIntestinal MucosaMaleMatrix Metalloproteinase 9Middle AgedTissue Inhibitor of Metalloproteinase-1Tissue Inhibitor of Metalloproteinase-2BiomarkersCyclophilin AMatrix Metalloproteinase 9Tissue Inhibitor of Metalloproteinase-1Tissue Inhibitor of Metalloproteinase-2Tumor Necrosis Factor-alphaCrohn’s diseaseCyclophilin AMatrix metalloproteinase 9Tissue inhibitor of metalloproteinaseUlcerative colitis

Identifiers

PMID28391416
OpenAlexW2604988393

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.