Evidence map›Paper›PMID 28391359›Full record

ArticleImmunogenetics2017

The prevalence of the variants of the L-ficolin gene (FCN2) in the arctic populations of East Siberia.

Marina V Smolnikova, Maxim B Freidin, Sergey Yu Tereshchenko

Abstract read
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In one paragraph

Article in Immunogenetics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Marina V SmolnikovaFederal Research Center "Krasnoyarsk Science Center" of the Siberian Branch of the Russian Academy of Sciences, Scientific Research Institute of medical problems of the North, Partizana Zheleznyaka street, 3G, Krasnoyarsk, Russia, 660022.
Maxim B FreidinResearch Institute of Medical Genetics, Tomsk NRMC, 10 Nab. Ushaiki, Tomsk, Russia, 634050.
Sergey Yu TereshchenkoFederal Research Center "Krasnoyarsk Science Center" of the Siberian Branch of the Russian Academy of Sciences, Scientific Research Institute of medical problems of the North, Partizana Zheleznyaka street, 3G, Krasnoyarsk, Russia, 660022. legise@mail.ru.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

L-ficolin encoded by FCN2 gene is a crucial factor of defence against infection in humans. We studied the prevalence of the two common variants (rs17549193 and rs7851696) in aboriginal and alien populations of the Taymyr-Dolgan-Nenets region of Krasnoyarskiy Kray, East Siberia, Russia (Nenets, Dolgans, Nganasans, Russians). We found a decreased prevalence of the rs17549193*T allele in all aboriginal populations as compared to Russians. Also, its frequency was the lowest in the Nenets among the studied populations, while frequency of the rs7851696*T allele was increased in this population. The results suggest that the Arctic populations of East Siberia are characterised by specificity of genetic make-up responsible for the activity of L-ficolin. Clinical and epidemiological studies are required to discover if these genetic features correlate with the infant infectious morbidity in East Siberian populations.

Indexed as

Genetics, PopulationGenetic VariationAllelesArctic RegionsFicolinsGene FrequencyGene OrderGenotypeHumansInfant, NewbornLectinsOdds RatioPolymorphism, Single NucleotideSiberiaFicolinsLectinsCircumpolar areaEthnic groupsL-ficolinNewbornsRussiaSNPs

Identifiers

PMID28391359

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.