Evidence map›Paper›PMID 28391295›Full record

ArticleNeuro-oncology2017

Diagnosis and treatment of brain metastases from solid tumors: guidelines from the European Association of Neuro-Oncology (EANO).

Riccardo Soffietti, Ufuk Abacioglu, Brigitta Baumert, Stephanie E Combs, Sara Kinhult, Johan M Kros, Christine Marosi, Philippe Metellus, Alexander Radbruch, Salvador S Villa Freixa and 8 more

Abstract read
In one paragraph

Article in Neuro-oncology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 267 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
267citing papers in PubMed, 8 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

267 citing papers in PubMed, 8 syntheses or guidelines pooled it.

  1. Pooled it
  2. Efficacy and safety evaluation of combined therapies incorporating whole-brain radiotherapy in patients with brain metastases: a systematic review and meta-analysis.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2024
    Pooled it
  3. DEGRO guideline for personalized radiotherapy of brain metastases and leptomeningeal carcinomatosis in patients with breast cancer.Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 2024
    Guideline
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  9. Trial
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  12. Article
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  15. Article
  16. Pneumocystis jirovecii pneumonia and prophylaxis in patients with solid tumours: a narrative review.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026
    Review
  17. Article
  18. Article
  19. Review
  20. Focused ultrasound for brain metastases.Neuro-oncology advances · 2026
    Review

207 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Riccardo SoffiettiDepartment of Neuro-Oncology, University and City of Health and Science Hospital, Turin, Italy.
Ufuk AbaciogluDepartment of Radiation Oncology, Neolife Medical Center, Istanbul, Turkey.
Brigitta BaumertDepartment of Radiation-Oncology, MediClin Robert-Janker-Klinik, Bonn, Germany.
Stephanie E CombsDepartment of Innovative Radiation Oncology and Radiation Sciences, Munich, Germany.
Sara KinhultDepartment of Oncology, Skane University Hospital, Lund, Sweden.
Johan M KrosDepartment of Pathology, Erasmus MC Cancer Institute, Rotterdam, The Netherlands.
Christine MarosiDepartment of Internal Medicine, Division of Oncology, Medical University, Vienna, Austria.
Philippe MetellusDepartment of Internal Medicine, Division of Oncology, Medical University, Vienna, Austria.
Alexander RadbruchDepartment of Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Salvador S Villa FreixaDepartment of Radiation Oncology, Institut Català d'Oncologia, Hospital Universitari Germans Trias i Pujol, Badalona, Spain.
Michael BradaDepartment of Molecular and Clinical Cancer Medicine & Radiation Oncology, Liverpool, United Kingdom.
Carmine M CarapellaDepartment of Neuroscience, Division of Neurosurgery, Regina Elena Nat Cancer Institute, Rome, Italy.
Matthias PreusserDepartment of Medicine I and Comprehensive Cancer Center CNS Unit (CCC-CNS), Medical University of Vienna, Vienna, Austria.
Emilie Le RhunDepartment of Neurosurgery, Neuro-oncology, University Hospital, Lille, France.
Roberta RudàDepartment of Neuro-Oncology, University and City of Health and Science Hospital, Turin, Italy.
Joerg C TonnDepartment of Neurosurgery, University of Munich LMU, Munich, Germany.
Damien C WeberCentre for Proton Therapy, Paul Scherrer Institute, Villigen, Switzerland.
Michael WellerDepartment of Neurology, University Hospital Zurich, Zurich, Switzerland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The management of patients with brain metastases has become a major issue due to the increasing frequency and complexity of the diagnostic and therapeutic approaches. In 2014, the European Association of Neuro-Oncology (EANO) created a multidisciplinary Task Force to draw evidence-based guidelines for patients with brain metastases from solid tumors. Here, we present these guidelines, which provide a consensus review of evidence and recommendations for diagnosis by neuroimaging and neuropathology, staging, prognostic factors, and different treatment options. Specifically, we addressed options such as surgery, stereotactic radiosurgery/stereotactic fractionated radiotherapy, whole-brain radiotherapy, chemotherapy and targeted therapy (with particular attention to brain metastases from non-small cell lung cancer, melanoma and breast and renal cancer), and supportive care.

Indexed as

Brain NeoplasmsHumansNeoplasmsPractice Guidelines as Topicbrain metastaseschemotherapyneuroimagingneuropathologystereotactic radiosurgery/stereotactic fractionated radiotherapysupportive caresurgerytargeted therapywhole-brain radiation therapy

Identifiers

PMID28391295
PMCPMC5620494

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.