Evidence map›Paper›PMID 28391248›Full record

ArticleAnnals of the rheumatic diseases2017

Increased risk of rheumatoid arthritis among mothers with children who carry

Giovanna Ibeth Cruz, Xiaorong Shao, Hong Quach, Kimberly A Ho, Kirsten Sterba, Janelle A Noble, Nikolaos A Patsopoulos, Michael P Busch, Darrell J Triulzi, Wendy Sw Wong and 4 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of the rheumatic diseases, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 22 citations in OpenAlex.

  1. Review
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  8. Immunogenicity of a rheumatoid arthritis protective sequence when acquired through microchimerism.Proceedings of the National Academy of Sciences of the United States of America · 2019
    Article
  9. miRNA contributions to pediatric-onset multiple sclerosis inferred from GWAS.Annals of clinical and translational neurology · 2019
    Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors at 7 institutions in 1 country.

Giovanna Ibeth CruzSchool of Public Health, University of California Berkeley, Berkeley, California, USA.
Xiaorong ShaoSchool of Public Health, University of California Berkeley, Berkeley, California, USA.
Hong QuachSchool of Public Health, University of California Berkeley, Berkeley, California, USA.
Kimberly A HoDepartment of Medicine, University of San Francisco, Rosalind Russell/Ephraim P. Engleman Rheumatology Research Center, San Francisco, California, USA.
Kirsten SterbaDepartment of Medicine, University of San Francisco, Rosalind Russell/Ephraim P. Engleman Rheumatology Research Center, San Francisco, California, USA.
Janelle A NobleChildrens Hospital Oakland Research Institute, Oakland, California, USA.
Nikolaos A PatsopoulosBroad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, USA.
Michael P BuschLaboratory of Medicine, Blood Systems Research Institute, San Francisco, California, USA.
Darrell J TriulziDepartment of Pathology, University of Pittsburgh, Institute for Transfusion Medicine, Pittsburgh, Pennsylvania, USA.
Wendy Sw WongDivision of Medical Genomics, Inova Translational Medicine Institute, Falls Church, Virginia, USA.
Benjamin D SolomonDivision of Medical Genomics, Inova Translational Medicine Institute, Falls Church, Virginia, USA.
John E NiederhuberDivision of Medical Genomics, Inova Translational Medicine Institute, Falls Church, Virginia, USA.
Lindsey A CriswellDepartment of Medicine, University of California, San Francisco, San Francisco, California, USA.
Lisa F BarcellosDivision of Epidemiology, School of Public Health, University of California Berkeley, Berkeley, California, USA.
Berkeley Public Health Division · USUniversity of California, Berkeley · USUniversity of San Francisco · USBlood Systems Research Institute · USInstitute for Transfusion Medicine · USMassachusetts Institute of Technology · USUniversity of California, San Francisco · US

Funding

RESOURCE-BASED CENTER FOR THE ADVANCEMENT OF PRECISION MEDICINE IN RHEUMATOLOGYP30AR070155 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Mary C Nakamura · 2016 to 2026
$8.2M
Dissecting the HLA contribution to Rheumatoid ArthritisR01AI065841 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CRISWELL, LINDSEY ANN · 2006 to 2010
$3.2M
Immunogenetic Studies of Autoimmune DiseaseR01AI059829 · NIAID · UNIVERSITY OF CALIFORNIA BERKELEY · PI BARCELLOS, LISA F · 2004 to 2008
$1.9M
Mother-child genetic contributions to autoimmunityR21AI117879 · NIAID · UNIVERSITY OF CALIFORNIA BERKELEY · PI BARCELLOS, LISA F · 2015 to 2016
$447k
Fetal-Maternal Histocompatibility and Autoimmune DiseaseF31AI116064 · NIAID · UNIVERSITY OF CALIFORNIA BERKELEY · PI CRUZ, GIOVANNA · 2015 to 2016
$62k
NIAID NIH HHS F31 AI116064NIAID NIH HHS R01 AI059829NIAID NIH HHS R01 AI065841NIAID NIH HHS R21 AI117879NIAMS NIH HHS P30 AR070155
6 · The paper itself

Abstract

objectiveTo investigate whether a child's genotype affects a mother's risk of rheumatoid arthritis (RA) beyond the risk associated with her genotype and to test whether exposure to fetal alleles inherited from the father increases risk of RA among mothers without risk alleles.

methodsA case-control study was conducted among 1165 mothers (170 cases/995 controls) and their respective 1482 children. We tested the association between having any child with alleles encoding amino acids (AAs) associated with RA including the 'shared epitope' (SE) and DERAA AA sequences at positions 70-74; AA valine, lysine and alanine at positions 11, 71 and 74 of HLA-DRB1; aspartic acid at position 9 of HLA-B and phenylalanine at position 9 of DPB1. We used logistic regression models to estimate OR and 95% CI for each group of alleles, adjusting for maternal genotype and number of live births.

resultsWe found increased risk of RA among mothers who had any child with SE (OR 3.0; 95% CI 2.0 to 4.6); DERAA (OR 1.7; 95% CI 1.1 to 2.6); or valine (OR 2.3; 95% CI 1.6 to 3.5), lysine (OR 2.3; 95% CI 1.5 to 3.4) and alanine (OR 2.8; 95% CI 1.2 to 6.4) at DRB1 positions 11, 71 and 74, respectively. Among non-carrier mothers, increased risk of RA was associated with having children who carried DERAA (OR 1.7; 95% CI 1.0 to 2.7) and alleles encoding lysine at DRB1 position 71 (OR 2.3; 95% CI 1.5 to 4.8).

conclusionFindings support the hypothesis that a child's genotype can contribute independently to risk of RA among mothers.

Indexed as

AdultAgedAllelesArthritis, RheumatoidCase-Control StudiesFemaleGenotypeHLA-B AntigensHLA-DP beta-ChainsHLA-DRB1 ChainsHumansLogistic ModelsMaternal ExposureMiddle AgedMothersMultivariate AnalysisHLA-B AntigensHLA-DPB1 antigenHLA-DP beta-ChainsHLA-DRB1 Chainsautoimmune diseaseepidemiologyRheumatoid arthritis

Identifiers

PMID28391248
PMCPMC7450788
OpenAlexW2604340336

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.