ArticlePsychiatry research2017
Associations between serotonin transporter and behavioral traits and diagnoses related to anxiety.
Article in Psychiatry research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Prospective Association between Childhood Behavioral Inhibition and Anxiety: a Meta-Analysis.Journal of abnormal child psychology · 2020Pooled it
- NQO1 and NQO2 Gene Polymorphisms Related to Methamphetamine-Associated Psychosis in the Makassar Population, Indonesia.Noro psikiyatri arsivi · 2026Article
- Molecular Effect of Variants in Serotonin Transporter Gene in Women with Alcohol Use Disorder.Cells · 2025Article
- Article
- Association of serotonin system-related genes with homicidal behavior and criminal aggression in a prison population of Pakistani Origin.Scientific reports · 2021Article
- Pharmacotherapeutic Strategies and New Targets in OCD.Current topics in behavioral neurosciences · 2021Review
- Review
- Relationship Between the Incidence of Road Traffic Accidents, Psychological Characteristics, and Genotype in Bus Drivers in a Chinese Population.Medical science monitor : international medical journal of experimental and clinical research · 2018Article
- Assessing Panic: Bridging the Gap Between Fundamental Mechanisms and Daily Life Experience.Frontiers in neuroscience · 2018Review
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7 authors.
Funding
Abstract
The role of the serotonin transporter promoter-linked polymorphism (5-HTTLPR) in psychiatric disease remains unclear. Behavioral traits could serve as alternative outcomes that are stable, precede psychopathology, and capture more sub-clinical variation. We test associations between 5-HTTLPR and (1) behavioral traits and (2) clinical diagnoses of anxiety and depression. Second and third generation participants (N=203, 34.2±13.8 years, 54% female) at high- or low- familial risk for depression (where risk was defined by the presence of major depression in the 1st generation) were assessed longitudinally using the Schedule for Affective Disorders and Schizophrenia-lifetime interview, Barratt Impulsiveness Scale-11, Buss-Perry Aggression Questionnaire, and the NEO-Five Factor Inventory. High (but not low)-risk offspring with two risk (short, s) alleles had higher impulsivity (+13%), hostility (+31%) and neuroticism (+23%). SS was associated higher rates of panic (OR=7.05 [2.44, 20.38], p=0.0003) and phobic (OR=2.68[1.04, 6.93], p=0.04), but not other disorders. Impulsivity accounted for 16% of associations between 5-HTTLPR and panic, and 52% of association between 5-HTTLPR and phobias. We show that 5-HTTLPR predicts higher impulsivity, hostility, and neuroticism, and that impulsivity could serve as a useful independent outcome or intermediary phenotype in genetic studies of anxiety.
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