ArticleNeurobiology of aging2017
Resting-state networks associated with cognitive processing show more age-related decline than those associated with emotional processing.
Article in Neurobiology of aging, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 1 of them a synthesis that pooled it.
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Who cites it
38 citing papers in PubMed, 1 synthesis or guideline pooled it, 66 citations in OpenAlex.
- The older adult brain is less modular, more integrated, and less efficient at rest: A systematic review of large-scale resting-state functional brain networks in aging.Psychophysiology · 2023Pooled it
- Trial
- Dynamic brain connectivity patterns induced by oxytocin: An fMRI Co-Activation pattern analysis study.Molecular psychiatry · 2026Article
- Correspondence of large-scale functional brain network decline across aging mice and humans.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Structural and functional alterations of posterior cingulate cortex subregions in successful cognitive aging.Frontiers in aging neuroscience · 2026Article
- Neurocognitive Performance and Executive Functions Do Not Influence Conditioned Pain Modulation in Women with Migraine.Life (Basel, Switzerland) · 2025Article
- Eye movement evidence for locus coeruleus-noradrenaline system contributions to age differences in attention.Psychology and aging · 2025Article
- Brain network segregation is associated with drug use severity in individuals with opioid use disorder.Drug and alcohol dependence · 2025Article
- Network segregation is associated with processing speed in the cognitively healthy oldest-old.eLife · 2025Article
- Prenatal environment is associated with the pace of cortical network development over the first three years of life.Nature communications · 2024Article
- Aging impairs reactive attentional control but not proactive distractor inhibition.Journal of experimental psychology. General · 2024Article
- Edge-Community Entropy Is a Novel Neural Correlate of Aging and Moderator of Fluid Cognition.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Eye movements reveal age differences in how arousal modulates saliency priority but not attention processing speed.bioRxiv : the preprint server for biology · 2024Article
- Resting-state functional network segregation of the default mode network predicts valence bias across the lifespan.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Brain signal variability and executive functions across the life span.Network neuroscience (Cambridge, Mass.) · 2024Article
- Individual functional parcellation revealed compensation of dynamic limbic network organization in healthy ageing.Human brain mapping · 2023Article
- Interrelating differences in structural and functional connectivity in the older adult's brain.Human brain mapping · 2022Article
- Modular community structure of the face network supports face recognition.Cerebral cortex (New York, N.Y. : 1991) · 2022Article
- A Neuroimaging Signature of Cognitive Aging from Whole-Brain Functional Connectivity.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022Article
- Age-related changes of whole-brain dynamics in spontaneous neuronal coactivations.Scientific reports · 2022Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
Correlations in activity across disparate brain regions during rest reveal functional networks in the brain. Although previous studies largely agree that there is an age-related decline in the "default mode network," how age affects other resting-state networks, such as emotion-related networks, is still controversial. Here we used a dual-regression approach to investigate age-related alterations in resting-state networks. The results revealed age-related disruptions in functional connectivity in all 5 identified cognitive networks, namely the default mode network, cognitive-auditory, cognitive-speech (or speech-related somatosensory), and right and left frontoparietal networks, whereas such age effects were not observed in the 3 identified emotion networks. In addition, we observed age-related decline in functional connectivity in 3 visual and 3 motor/visuospatial networks. Older adults showed greater functional connectivity in regions outside 4 out of the 5 identified cognitive networks, consistent with the dedifferentiation effect previously observed in task-based functional magnetic resonance imaging studies. Both reduced within-network connectivity and increased out-of-network connectivity were correlated with poor cognitive performance, providing potential biomarkers for cognitive aging.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.