Evidence map›Paper›PMID 28390705›Full record

ArticleImmunobiology2017

The protection role of Atg16l1 in CD11c

Hong Zhang, Libo Zheng, Jeremy Chen, Masayuki Fukata, Ryan Ichikawa, David Q Shih, Xiaolan Zhang

Open access · greenAbstract read
In one paragraph

Article in Immunobiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 24 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Hong ZhangDepartment of Gastroenterology, The Second Hospital of Hebei Medical University, Hebei, China; F. Widjaja Foundation, Inflammatory Bowel & Immunobiology Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA90048, USA.
Libo ZhengDepartment of Gastroenterology, The Second Hospital of Hebei Medical University, Hebei, China.
Jeremy ChenF. Widjaja Foundation, Inflammatory Bowel & Immunobiology Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA90048, USA.
Masayuki FukataF. Widjaja Foundation, Inflammatory Bowel & Immunobiology Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA90048, USA.
Ryan IchikawaF. Widjaja Foundation, Inflammatory Bowel & Immunobiology Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA90048, USA.
David Q ShihF. Widjaja Foundation, Inflammatory Bowel & Immunobiology Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA90048, USA.
Xiaolan ZhangDepartment of Gastroenterology, The Second Hospital of Hebei Medical University, Hebei, China. Electronic address: xiaolanzh@126.com.
Cedars-Sinai Medical Center · USSecond Hospital of Hebei Medical University · CNHebei Medical University · CN

Funding

Using polygenic scores to enhance both variant discovery, and understanding of functional consequences of genetic variation in IBD.P01DK046763 · NIDDK · CEDARS-SINAI MEDICAL CENTER · PI TARGAN, STEPHAN R. · 1992 to 2020
$31.1M
Utilizing the Phenomics of IBD to Enhance Gene DiscoveryU01DK062413 · NIDDK · CEDARS-SINAI MEDICAL CENTER · PI Dermot Patrick McGovern · 2002 to 2026
$12.2M
Characterizing the gut microbial ecosystem for diagnosis and therapy in IBDU54DK102557 · NIDDK · BROAD INSTITUTE, INC. · PI HUTTENHOWER, CURTIS, XAVIER, RAMNIK J · 2014 to 2015
$7.7M
The Roles of IBD Associated Genes ATG16L1 and TNFSF15 in Gut Mucosal InflammationK08DK093578 · NIDDK · CEDARS-SINAI MEDICAL CENTER · PI SHIH, DAVID Q. · 2012 to 2016
$755k
NIDDK NIH HHS K08 DK093578NIDDK NIH HHS P01 DK046763NIDDK NIH HHS U01 DK062413NIDDK NIH HHS U54 DK102557
6 · The paper itself

Abstract

The autophagy-related 16-like 1 gene (Atg16l1) is associated with inflammatory bowel disease (IBD) and has been shown to play an essential role in paneth cell function and intestinal homeostasis. However, the functional consequences of Atg16l1 deficiency in myeloid cells, particularly in dendritic cells (DCs), are not fully characterized. The aim of this study is to investigate the functional consequence of Atg16l1 in CD11c

Indexed as

AnimalsAntigen PresentationAutophagosomesAutophagyAutophagy-Related ProteinsCarrier ProteinsCD11c AntigenColitisCytokinesDendritic CellsDextran SulfateDisease Models, AnimalDisease ProgressionDisease SusceptibilityImmunoglobulin AInflammation MediatorsAtg16l1 protein, mouseAutophagy-Related ProteinsCarrier ProteinsCD11c AntigenCytokinesDextran SulfateImmunoglobulin AInflammation MediatorsReactive Oxygen SpeciesAtg16l1AutophagyDendritic cellsIgAInflammatory bowel diseaseROS

Identifiers

PMID28390705
PMCPMC5610573
OpenAlexW2596039875

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.