ArticleBMC infectious diseases2017
Regulatory monocytes in helminth infections: insights from the modulation during human hookworm infection.
Article in BMC infectious diseases, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 22 citations in OpenAlex.
- Helminth Seropositivity Inversely Correlated with Th1 and Th17 Cytokines and Severe COVID-19.Vaccines · 2025Article
- Monocytes/Macrophages in Helminth Infections: Key Players in Host Defence, Inflammation, and Tissue Repair.Results and problems in cell differentiation · 2024Review
- Macrophages drive KSHV B cell latency.Cell reports · 2023Article
- Changes in phenotypic patterns of blood monocytes after kidney transplantation and during acute rejection.Physiological research · 2021Article
- Helminth species specific expansion and increased TNF-alpha production of non-classical monocytes during active tuberculosis.PLoS neglected tropical diseases · 2021Article
- Therapeutic Efficacy of Excretory-Secretory Products ofFrontiers in cellular and infection microbiology · 2021Article
- Ovine CD14- an Immune Response Gene Has a Role Against Gastrointestinal NematodeFrontiers in immunology · 2021Article
- Plasmodium sporozoites induce regulatory macrophages.PLoS pathogens · 2020Article
- Therapeutic efficacy of Schistosoma japonicum cystatin on sepsis-induced cardiomyopathy in a mouse model.Parasites & vectors · 2020Article
- Adoptive transfer of Trichinella spiralis-activated macrophages can ameliorate both Th1- and Th2-activated inflammation in murine models.Scientific reports · 2019Article
- Involvement of Hookworm Co-Infection in the Pathogenesis and Progression of Podoconiosis: Possible Immunological Mechanism.Tropical medicine and infectious disease · 2018Review
- Helminth parasites and immune regulation.F1000Research · 2018Review
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWhile the macrophage polarization is well characterized in helminth infections, the natural heterogeneity of monocytes with multiple cell phenotypes might influence the outcome of neglected diseases, such hookworm infection. Here, we report the profile of monocytes in human hookworm infections as a model to study the regulatory subpopulation of monocytes in helminth infections.
methodsBlood samples were collected from 19 Necator americanus-infected individuals and 13 healthy individuals. Peripheral blood mononuclear cells (PBMCs) were isolated, and immunophenotyping was conducted by flow cytometry. The expressions of genes encoding human nitric oxide synthase (iNOS), interleukin 4 (IL-4), arginase-1 (Arg-1) and glyceraldehyde 3-phosphate dehydrogenase were quantified by qPCR. Plasma levels of IL-4 were determined by sandwich ELISA. Unpaired t-tests or Mann-Whitney tests were used depending on the data distribution.
resultsHookworm infected individuals (HWI) showed a significant increase in the number of monocytes/mm
conclusionsNatural hookworm infection induces a high frequency of circulating monocytes that present a regulatory profile and promote the downmodulation of the proinflammatory response, which may contribute to prolonged survival of the parasite in the host.
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