ArticleMedicina oral, patologia oral y cirugia bucal2017
Comparative histological and immunohistochemical study of ameloblastomas and ameloblastic carcinomas.
Article in Medicina oral, patologia oral y cirugia bucal, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.
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Who cites it
18 citing papers in PubMed, 2 syntheses or guidelines pooled it, 41 citations in OpenAlex.
- Differential Expression of Immunohistochemical Markers in Ameloblastoma & Ameloblastic Carcinoma: A Systematic Review and Meta-analysis of observational studies.F1000Research · 2024Pooled it
- Adenoid Ameloblastoma with Dentinoid: A systematic review.Sultan Qaboos University medical journal · 2022Pooled it
- Adenoid ameloblastoma of the mandible: report of a new case of a distinct type of odontogenic neoplasms.BMC oral health · 2026Article
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- Ameloblastoma with adenoid features with multiple local recurrences: report of a case with clinicopathologic and immunohistochemical studies.International journal of clinical and experimental pathology · 2025Article
- Comparative Immunohistochemical Analysis of Craniopharyngioma and Ameloblastoma: Insights into Odontogenic Differentiation.Diagnostics (Basel, Switzerland) · 2024Article
- Metastasising ameloblastoma or ameloblastic carcinoma? A case report with mutation analyses.BMC oral health · 2023Review
- Comparison of the IHC Markers CD138 and CD43 in Oral Leukoplakia: An Original Research.Journal of pharmacy & bioallied sciences · 2023Article
- Malignant Ameloblastoma with Hepatic Metastasis in a 38-Year-Old Haitian Woman.The American journal of case reports · 2021Article
- Expression Profile of Stemness Markers CD138, Nestin and Alpha-SMA in Ameloblastic Tumours.International journal of environmental research and public health · 2021Article
- Expression of caveolin-1 in tooth germ, ameloblastoma and ameloblastic carcinoma.Medicina oral, patologia oral y cirugia bucal · 2021Article
- IKKβ overexpression together with a lack of tumour suppressor genes causes ameloblastic odontomas in mice.International journal of oral science · 2020Article
- Ameloblastic Carcinoma in a 2-Year-Old Child: A Case Report and Review of the Literature.Case reports in dentistry · 2020Article
- Ameloblastic Carcinoma with Calcification: A Rare Case Report in the Mandible and Literature Review.Case reports in dentistry · 2020Article
- Stem Cell Markers SOX-2 and OCT-4 Enable to Resolve the Diagnostic Dilemma between Ameloblastic Carcinoma and Aggressive Solid Multicystic Ameloblastoma.Advanced biomedical research · 2018Article
- Differences in E-Cadherin and Syndecan-1 Expression in Different Types of Ameloblastomas.Analytical cellular pathology (Amsterdam) · 2018Article
- Clear-Cell Variant of Ameloblastic Carcinoma: Pathological Insights for a more Specific Categorization.Journal of microscopy and ultrastructureArticle
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Authors and funding
8 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThis study aimed to compare the histological and immunohistochemical characteristics of ameloblastomas (AM) and ameloblastic carcinomas (AC). MATERIAL AND
methodsFifteen cases of AM and 9 AC were submitted to hematoxilin and eosin (H&E) and immunohistochemical analysis with the following antibodies: cytokeratins 5,7,8,14 and 19, Ki-67, p53, p63 and the cellular adhesion molecules CD138 (Syndecan-1), E-cadherin and β-catenin. The mean score of the expression of Ki-67 and p53 labelling index (LIs) were compared between the groups using the t test. A value of p<0.05 was considered to be statistically significant.
resultsAll cases were positive for CKs 5, 14 and 19, but negative for CKs 7 and 8. CKs 5 and 19 were positive mainly in the central regions of the ameloblastic islands, while the expression in AC was variable in intensity and localization. CK14 was also variably expressed in both AM and AC. Ki-67 (P=.001) and p53 (P=.004) immunoexpression was higher in AC. All cases were positive for p63, but values were higher in AC. CD138 was mainly expressed in peripheral cells of AM, with a weak positivity in the central areas, while it was positive in most areas of ACs, except in less differentiated regions, where expression was decreased or lost. E-cadherin and β-catenin were weakly positive in both AM and AC.
conclusionsThese results shows that Ki-67, p53 and p63 expression was higher in AC as compared to AM, suggesting that these markers can be useful when considering diagnosis of malignancy, and perhaps could play a role in malignant transformation of AM. Pattern of expression of CKs 5 and 19 in AC were different to those found in AM, suggesting genetic alterations of these proteins in malignant cells. It was confirmed that CK19 is a good marker for benign odontogenic tumors, such as AM, but it is variably expressed in malignant cases.
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