ArticleMedicina oral, patologia oral y cirugia bucal2017
Primordial odontogenic tumor: An immunohistochemical profile.
Article in Medicina oral, patologia oral y cirugia bucal, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 3 of them syntheses that pooled it.
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Who cites it
17 citing papers in PubMed, 3 syntheses or guidelines pooled it, 37 citations in OpenAlex.
- Primordial Odontogenic Tumor: A Decade Post-Description Systematic Review.Head and neck pathology · 2024Pooled it
- Prevalence of BRAF p.V600E and Detection Methods in Benign Mixed and Malignant Odontogenic Tumors: A Systematic Review.Head and neck pathology · 2023Pooled it
- Primordial odontogenic tumor: A systematic review.Medicina oral, patologia oral y cirugia bucal · 2020Pooled it
- Differences of immunohistochemical profiling of MOC-31, caveolin-1, connexin-43, Ki-67 in ameloblastic fibroma, ameloblastic fibrodentinoma, ameloblastic fibro-odontoma, and odontomas.World journal of experimental medicine · 2026Article
- Algorithmic analysis of the structure of mixed odontogenic tumors.Scientific reports · 2026Article
- Primordial Odontogenic Tumor Associated with Impacted Supernumerary Tooth: First Case Report and an Updated Review of Literature.Journal of maxillofacial and oral surgery · 2025Article
- Histopathological spectrum of primordial odontogenic tumor with co-existing dentigerous cyst: 1Diagnostic pathology · 2024Article
- Primordial Odontogenic Tumor; Archival Review of 19380 Cases in a 55-Year Retrospective Study.Asian Pacific journal of cancer prevention : APJCP · 2023Review
- Primordial odontogenic tumour: a case report.Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology · 2022Article
- Identification of BRAF V600E mutation in odontogenic tumors by high-performance MALDI-TOF analysis.International journal of oral science · 2022Article
- Expression of caveolin-1 in tooth germ, ameloblastoma and ameloblastic carcinoma.Medicina oral, patologia oral y cirugia bucal · 2021Article
- Primordial odontogenic tumor: a case report and literature review.Diagnostic pathology · 2019Review
- Primordial Odontogenic Tumor: Report of a New Case and Literature Review.Head and neck pathology · 2019Review
- The Challenging Diagnosis of Primordial Odontogenic Tumor.Case reports in dentistry · 2019Article
- PITX2 DNA-methylation predicts response to anthracycline-based adjuvant chemotherapy in triple-negative breast cancer patients.International journal of oncology · 2018Article
- New tumour entities in the 4th edition of the World Health Organization Classification of Head and Neck tumours: odontogenic and maxillofacial bone tumours.Virchows Archiv : an international journal of pathology · 2018Review
- Proteoglycans as potential biomarkers in odontogenic tumors.Journal of oral and maxillofacial pathology : JOMFPReview
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Authors and funding
6 authors at 4 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPrimordial Odontogenic Tumor (POT) is a recently described odontogenic tumor characterized by a variably cellular loose fibrous tissue with areas similar to the dental papilla, covered by cuboidal to columnar epithelium that resembles the internal epithelium of the enamel organ, surrounded at least partly by a delicate fibrous capsule. The purpose of this study was to investigate the possible histogenesis and biological behavior of this rare tumor by means of a wide immunohistochemical analysis of its epithelial and mesenchymal components. MATERIAL AND
methodsThe immunoexpression of twenty-three different antibodies were evaluated in four cases of POT.
resultsThe epithelial cells that cover the periphery of the tumor showed immunopositivity for Cytokeratins 14 and 19, while Amelogenin, Glut-1, MOC-31, Caveolin-1. Galectin-3, PITX2, p53, Bax, Bcl-2, Survivin and PTEN were variably expressed in focal areas. The mesenchymal component of the tumor was positive for Vimentin, Syndecan-1, PITX2, Endoglin (CD105), CD 34, Cyclin D1, Bax, Bcl-2, Survivin and p53. PTEN and CD 90 showed a moderate positivity. BRAF V600E and Calretinin were negative in all samples. Cell proliferation markers (Ki-67, MCM-7) were expressed in <5% of the tumor cells.
conclusionsAccording to these immunohistochemical findings, we may conclude that POT is a benign odontogenic tumor in which there is both epithelial and mesenchymal activity during its histogenesis, as there is expression of certain components in particular zones in both tissues that suggests this tumor develops during the immature (primordial) stage of tooth development, leading to its inclusion within the group of benign mixed epithelial and mesenchymal odontogenic tumours in the current World Health Organization classification of these lesions.
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