ArticleJournal of veterinary internal medicine2017
Characterization of the Fecal Bacterial Microbiota of Healthy and Diarrheic Dairy Calves.
Article in Journal of veterinary internal medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 115 papers.
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Who cites it
115 citing papers in PubMed.
- Implementation of an algorithm for selection of antimicrobial therapy for diarrhoeic calves: Impact on antimicrobial treatment rates, health and faecal microbiota.Veterinary journal (London, England : 1997) · 2017Trial
- Gut microbiome dynamics in acute infectious diarrhea: A conceptual framework from acute dysbiosis toward precision restoration (Review).Experimental and therapeutic medicine · 2026Review
- Beyond the Rumen: Current Evidence and Knowledge Gaps in Microbial Diversity and Function Across the Bovine Gastrointestinal Tract.Current microbiology · 2026Review
- Comparative metagenomic and untargeted metabolomic analyses reveal gut microbiota and metabolite alterations associated with diarrhea in neonatal Holstein calves in Anhui, China.Veterinary world · 2026Article
- Effects of Probiotic Compounds as Feed Additives on Performance, Rumen Fermentation and Metabolic Blood Indices During the Preweaning Period of Holstein Dairy Calves.Animals : an open access journal from MDPI · 2026Article
- Early-life development of the microbiome and resistome in antibiotic-naïve dairy calves.Microbiology spectrum · 2026Article
- The Great Bustard (Ecology and evolution · 2026Article
- Differences in gut microbiome of Hanwoo (Korean indigenous cattle) calves as driven by bovine rotavirus and bovine coronavirus infection.Journal of animal science and technology · 2026Article
- Harnessing the early-life gut microbiome for sustainable ruminant production.Animal microbiome · 2026Review
- The effect of supplementing pre-weaning dairy calves' starter feed withJournal of advanced veterinary and animal research · 2026Article
- Early-Life Galacto-Oligosaccharide Supplementation Induces Persistent Immunoglobulin and Metabolic Alterations in Holstein Dairy Calves by Shaping Gut Microbiota.Animals : an open access journal from MDPI · 2026Article
- Impact of transport source (dairy farms vs. collection center) and post-arrival housing in combination with prophylactic antibiotic treatment on performance, lung health and microbiota of veal calves.Frontiers in veterinary science · 2026Article
- Changes in fecal microbiota after therapeutic exposure to amoxicillin-clavulanic acid in veal calves receiving multiple antibiotics.Microbiology spectrum · 2025Article
- Gut microbiota in diarrheic and healthy calves: comparative analysis of 16S rRNA gene full-length sequences.BMC veterinary research · 2025Article
- Effect of Multi-Species Probiotic Supplementation on Fecal Microbiota in Pre-Weaned Holstein Dairy Calves in California.Microorganisms · 2025Article
- Investigating gut permeability in neonatal calves with diarrhea: A case-control study.JDS communications · 2025Article
- Gut microbiome reveals the trophic variation and significant adaption of three sympatric forest-dwelling ungulates on the eastern Qinghai-Xizang Plateau.BMC microbiology · 2025Article
- The Therapeutic Potential of Gut-Microbiota-Derived Metabolite 4-Phenylbutyric Acid inInternational journal of molecular sciences · 2025Article
- Stochasticity Highlights the Development of Both the Gastrointestinal and Upper-Respiratory-Tract Microbiomes of Neonatal Dairy Calves in Early Life.Animals : an open access journal from MDPI · 2025Article
- Progression of the faecal microbiome in preweaning dairy calves that develop cryptosporidiosis.Animal microbiome · 2025Article
55 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundNeonatal diarrhea accounts for more than 50% of total deaths in dairy calves. Few population-based studies of cattle have investigated how the microbiota is impacted during diarrhea.
objectivesTo characterize the fecal microbiota and predict the functional potential of the microbial communities in healthy and diarrheic calves.
methodsFifteen diarrheic calves between the ages of 1 and 30 days and 15 age-matched healthy control calves were enrolled from 2 dairy farms. The Illumina MiSeq sequencer was used for high-throughput sequencing of the V4 region of the 16S rRNA gene (Illumina, San Diego, CA).
resultsSignificant differences in community membership and structure were identified among healthy calves from different farms. Differences in community membership and structure also were identified between healthy and diarrheic calves within each farm. Based on linear discriminant analysis effect size (LEfSe), the genera Bifidobacterium, Megamonas, and a genus of the family Bifidobacteriaceae were associated with health at farm 1, whereas Lachnospiraceae incertae sedis, Dietzia and an unclassified genus of the family Veillonellaceae were significantly associated with health at farm 2. The Phylogenetic Investigation of Communities Reconstruction of Unobserved States (PICRUSt) analysis indicated that diarrheic calves had decreased abundances of genes responsible for metabolism of various vitamins, amino acids, and carbohydrate. CLINICAL RELEVANCE: The fecal microbiota of healthy dairy calves appeared to be farm specific as were the changes observed during diarrhea. The differences in microbiota structure and membership between healthy and diarrheic calves suggest that dysbiosis can occur in diarrheic calves and it is associated with changes in predictive metagenomic function.
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