ArticleJournal of gastroenterology2018
Celiac disease in non-clinical populations of Japan.
Article in Journal of gastroenterology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 2 of them syntheses that pooled it.
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Who cites it
29 citing papers in PubMed, 2 syntheses or guidelines pooled it, 60 citations in OpenAlex.
- Diagnostic Accuracy of IgA Anti-Transglutaminase Assessed by Chemiluminescence: A Systematic Review and Meta-Analysis.Nutrients · 2024Pooled it
- Prevalence of celiac disease in low and high risk population in Asia-Pacific region: a systematic review and meta-analysis.Scientific reports · 2021Pooled it
- Cross-national comparison of inflammatory bowel disease burden in China, Japan, the United States, and India: An age-period-cohort analysis of GBD 2021.Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association · 2025Article
- Prevalence of celiac disease in patients with type 1 diabetes mellitus: a single-center cross-sectional cohort study.Journal of clinical biochemistry and nutrition · 2024Article
- Knee Extensor Muscle Strength Associated with the Onset of Depression in Older Japanese Women: The Otassha Study.Nutrients · 2024Article
- From an understanding of etiopathogenesis to novel therapies-what is new in the treatment of celiac disease?Frontiers in pharmacology · 2024Review
- Celiac Disease Genetics, Pathogenesis, and Standard Therapy for Japanese Patients.International journal of molecular sciences · 2023Review
- Development of Gluten-Free Rice Flour Noodles That Suit the Tastes of Japanese People.Foods (Basel, Switzerland) · 2022Article
- Endoscopic diagnosis of chronic diarrhea.DEN open · 2022Review
- Epidemiological, clinical, and histological presentation of celiac disease in Northwest China.World journal of gastroenterology · 2022Article
- Celiac Disease Diagnosed after Gastrectomy for Gastric Cancer.Internal medicine (Tokyo, Japan) · 2022Article
- Prevalence of Autoimmune Disease in Patients with Eosinophilic Esophagitis: A Cross-sectional Study of Three Hospitals in Japan.Internal medicine (Tokyo, Japan) · 2021Article
- Emergence of Celiac disease and Gluten-related disorders in Asia.Journal of neurogastroenterology and motility · 2021Review
- Celiac Disease: Fallacies and Facts.The American journal of gastroenterology · 2021Review
- Celiac Disease in Asia beyond the Middle East and Indian subcontinent: Epidemiological burden and diagnostic barriers.World journal of gastroenterology · 2021Article
- Evidence-based clinical practice guidelines for irritable bowel syndrome 2020.Journal of gastroenterology · 2021Article
- Celiac Disease Complicated by Rhabdomyolysis.Internal medicine (Tokyo, Japan) · 2021Article
- Article
- Opportunities and challenges in the management of celiac disease in Asia.JGH open : an open access journal of gastroenterology and hepatology · 2020Review
- Extremely low prevalence of Celiac disease in Japan: Eternal silence or just the calm before the storm?JGH open : an open access journal of gastroenterology and hepatology · 2020Article
Corrections and comments
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Authors and funding
12 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCeliac disease is a chronic autoimmune enteropathy caused by gluten ingestion. While its prevalence in Western countries is reported to be as high as 1%, the prevalence has not been evaluated in a large-scale study of a Japanese population. The aim of our study was to clarify the possible presence of celiac disease in a Japanese non-clinical population as well as in patients showing symptoms suggestive of the disease.
methodsSerum samples were collected from 2008 non-clinical adults and 47 patients with chronic unexplained abdominal symptoms between April 2014 and June 2016. The anti-tissue transglutaminase (TTG) immunoglobulin A antibody titer was determined as a screening test for celiac disease in all subjects, and individuals with a value of >2 U/mL subsequently underwent testing for the presence of serum endomysial IgA antibody (EMA) as confirmation. Those testing positive for EMA or with a high concentration (>10 U/mL) of TTG were further investigated by histopathological examinations of duodenal mucosal biopsy specimens and HLA typing tests.
resultsOf the 2008 non-clinical adults from whom serum samples were collected, 161 tested positive for TTG, and all tested negative for EMA. Four subjects who had a high TTG titer were invited to undergo confirmatory testing, and the histopathological results confirmed the presence of celiac disease in only a single case (0.05%). Of the 47 symptomatic patients, one (2.1%) was found to have a high TTG titer and was diagnosed with celiac disease based on duodenal histopathological findings.
conclusionThe presence of celiac disease in a non-clinical Japanese population was low at 0.05% and was rarely found in patients with unexplained chronic abdominal symptoms.
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