Evidence map›Paper›PMID 28389691›Full record

ArticleCalcified tissue international2017

Deletion of Adseverin in Osteoclasts Affects Cell Structure But Not Bone Metabolism.

Yixuan Cao, Yongqiang Wang, Sara Sprangers, Daisy I Picavet, Michael Glogauer, Christopher A McCulloch, Vincent Everts

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Calcified tissue international, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yixuan CaoDepartment of Oral Cell Biology and Functional Anatomy, Academic Centre for Dentistry Amsterdam (ACTA), Research Institute MOVE, University of Amsterdam and VU University Amsterdam, 11N-43, Gustav Mahlerlaan 3004, 1081 LA, Amsterdam, The Netherlands. y.cao@acta.nl.ORCID 0000-0002-6025-637X
Yongqiang WangMatrix Dynamics Group, Faculty of Dentistry, University of Toronto, Ontario, Canada.
Sara SprangersDepartment of Oral Cell Biology and Functional Anatomy, Academic Centre for Dentistry Amsterdam (ACTA), Research Institute MOVE, University of Amsterdam and VU University Amsterdam, 11N-43, Gustav Mahlerlaan 3004, 1081 LA, Amsterdam, The Netherlands.
Daisy I PicavetDepartment of Cell Biology and Histology, Core Facility Cellular Imaging, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.
Michael GlogauerMatrix Dynamics Group, Faculty of Dentistry, University of Toronto, Ontario, Canada.
Christopher A McCullochMatrix Dynamics Group, Faculty of Dentistry, University of Toronto, Ontario, Canada.
Vincent EvertsDepartment of Oral Cell Biology and Functional Anatomy, Academic Centre for Dentistry Amsterdam (ACTA), Research Institute MOVE, University of Amsterdam and VU University Amsterdam, 11N-43, Gustav Mahlerlaan 3004, 1081 LA, Amsterdam, The Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Adseverin is an actin-severing/capping protein that may contribute to osteoclast differentiation in vitro but its role in bone remodeling of healthy animals is not defined. We analyzed bone and osteoclast structure in adseverin conditional null mice at alveolar and long bone sites. In wild-type and adseverin null mice, as measured by dual-energy X-ray absorptiometry, there were no differences of bone mineral content or bone mineral density, indicating no change of bone metabolism. In tibiae, TRAcP

Indexed as

Absorptiometry, PhotonAnimalsBone and BonesBone DensityBone ResorptionCell DifferentiationGelsolinMice, Inbred C57BLMice, KnockoutMicrofilament ProteinsOsteoclastsGelsolinMicrofilament ProteinsscinderinAdseverinMorphologyOsteoclastTransmission electron microscopy

Identifiers

PMID28389691
PMCPMC5498625

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.