ArticleInvestigative ophthalmology & visual science2017
Deformation of the Lamina Cribrosa and Optic Nerve Due to Changes in Cerebrospinal Fluid Pressure.
Article in Investigative ophthalmology & visual science, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
33 citing papers in PubMed, 64 citations in OpenAlex.
- Optic Nerve Subarachnoid Space Posture Dependency - An MRI Study in Subjects With Normal Tension Glaucoma and Healthy Controls.Investigative ophthalmology & visual science · 2023Trial
- Response of the Rat Eye to Acute and Chronic Optic Nerve Pressure Modifications.Investigative ophthalmology & visual science · 2026Article
- Continuous Wireless Telemetric Measurement of Intraocular Pressure (IOP), Ocular Perfusion Pressure (OPP), and Cerebrospinal Fluid Pressure (CSFP) in Nonhuman Primates (NHPs).Methods in molecular biology (Clifton, N.J.) · 2025Article
- Fibrous finite element modeling of the optic nerve head region.Acta biomaterialia · 2024Article
- Ocular Deformations in Spaceflight-Associated Neuro-Ocular Syndrome and Idiopathic Intracranial Hypertension.Investigative ophthalmology & visual science · 2023Article
- Association between Optic Nerve Sheath Diameter and Lamina Cribrosa Morphology in Normal-Tension Glaucoma.Journal of clinical medicine · 2023Article
- CXC- receptor 2 promotes extracellular matrix production and attenuates migration in peripapillary human scleral fibroblasts under mechanical strain.Journal of cellular and molecular medicine · 2022Article
- Comparing Acute IOP-Induced Lamina Cribrosa Deformations Premortem and Postmortem.Translational vision science & technology · 2022Article
- The ex vivo human translaminar autonomous system to study spaceflight associated neuro-ocular syndrome pathogenesis.NPJ microgravity · 2022Article
- Relative Contributions of Intraocular and Cerebrospinal Fluid Pressures to the Biomechanics of the Lamina Cribrosa and Laminar Neural Tissues.Investigative ophthalmology & visual science · 2022Article
- Eye-specific 3D modeling of factors influencing oxygen concentration in the lamina cribrosa.Experimental eye research · 2022Article
- A Potential Role of Acute Choroidal Expansion in Nonarteritic Anterior Ischemic Optic Neuropathy.Investigative ophthalmology & visual science · 2022Article
- Interplay between intraocular and intracranial pressure effects on the optic nerve head in vivo.Experimental eye research · 2021Article
- Material properties and effect of preconditioning of human sclera, optic nerve, and optic nerve sheath.Biomechanics and modeling in mechanobiology · 2021Article
- Review
- Quantification of Translaminar Pressure Gradient (TLPG) With Continuous Wireless Telemetry in Nonhuman Primates (NHPs).Translational vision science & technology · 2020Article
- IOP-induced regional displacements in the optic nerve head and correlation with peripapillary sclera thickness.Experimental eye research · 2020Article
- Morphometric, Hemodynamic, and Biomechanical Factors Influencing Blood Flow and Oxygen Concentration in the Human Lamina Cribrosa.Investigative ophthalmology & visual science · 2020Article
- Diurnal Cycle of Translaminar Pressure in Nonhuman Primates Quantified With Continuous Wireless Telemetry.Investigative ophthalmology & visual science · 2020Article
- Modeling a potential SANS countermeasure by experimental manipulation of the translaminar pressure difference in mice.NPJ microgravity · 2020Article
Corrections and comments
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Authors and funding
9 authors at 8 institutions in 3 countries.
Funding
Abstract
Purpose: Cerebrospinal fluid pressure (CSFp) changes are involved or implicated in various ocular conditions including glaucoma, idiopathic intracranial hypertension, and visual impairment and intracranial pressure syndrome. However, little is known about the effects of CSFp on lamina cribrosa and retrolaminar neural tissue (RLNT) biomechanics, potentially important in these conditions. Our goal was to use an experimental approach to visualize and quantify the deformation of these tissues as CSFp increased. Methods: The posterior eye and RLNT of porcine eyes (n = 3) were imaged using synchrotron radiation phase-contrast micro-computed tomography (PC μCT) at an intraocular pressure of 15 mm Hg and CSFps of 4, 10, 20, and 30 mm Hg. Scans of each tissue region were acquired at each CSFp step and analyzed using digital volume correlation to determine 3-dimensional tissue deformations. Results: Elevating CSFp increased the strain in the lamina cribrosa and RLNT of all three specimens, with the largest strains occurring in the RLNT. Relative to the baseline CSFp of 4 mm Hg, at 30 mm Hg, the lamina cribrosa experienced a mean first and third principal strain of 4.4% and -3.5%, respectively. The corresponding values for the RLNT were 9.5% and -9.1%. Conclusions: CSFp has a significant impact on the strain distributions within the lamina cribrosa and, more prominently, within the RLNT. Elevations in CSFp were positively correlated with increasing deformations in each region and may play a role in ocular pathologies linked to changes in CSFp.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.