Evidence map›Paper›PMID 28389619›Full record

ArticleMolecular cancer research : MCR2017

Differential Expression of OATP1B3 Mediates Unconjugated Testosterone Influx.

Tristan M Sissung, Ariel M Ley, Jonathan D Strope, Edel M McCrea, Shaunna Beedie, Cody J Peer, Suneet Shukla, Jennifer van Velkinburgh, Kelie Reece, Sarah Troutman and 14 more

Open access · bronzeAbstract read
In one paragraph

Article in Molecular cancer research : MCR, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 18 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors at 1 institution in 1 country.

Tristan M SissungClinical Pharmacology Program, Office of the Clinical Director, NCI, Bethesda, Maryland.
Ariel M LeyMolecular Pharmacology Section, Genitourinary Malignancies Branch, NCI, Bethesda, Maryland.
Jonathan D StropeMolecular Pharmacology Section, Genitourinary Malignancies Branch, NCI, Bethesda, Maryland.
Edel M McCreaMolecular Pharmacology Section, Genitourinary Malignancies Branch, NCI, Bethesda, Maryland.
Shaunna BeedieMolecular Pharmacology Section, Genitourinary Malignancies Branch, NCI, Bethesda, Maryland.
Cody J PeerClinical Pharmacology Program, Office of the Clinical Director, NCI, Bethesda, Maryland.
Suneet ShuklaLaboratory of Cell Biology, NCI, Bethesda, Maryland.
Jennifer van VelkinburghMolecular Pharmacology Section, Genitourinary Malignancies Branch, NCI, Bethesda, Maryland.
Kelie ReeceMolecular Pharmacology Section, Genitourinary Malignancies Branch, NCI, Bethesda, Maryland.
Sarah TroutmanMolecular Pharmacology Section, Genitourinary Malignancies Branch, NCI, Bethesda, Maryland.
Tessa CampbellMolecular Pharmacology Section, Genitourinary Malignancies Branch, NCI, Bethesda, Maryland.
Elena FernandezMolecular Pharmacology Section, Genitourinary Malignancies Branch, NCI, Bethesda, Maryland.
Phoebe HuangMolecular Pharmacology Section, Genitourinary Malignancies Branch, NCI, Bethesda, Maryland.
Jordan SmithLaboratory of Cancer Biology and Genetics, NCI, Bethesda, Maryland.
Nilay ThakkarDepartment of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, Kentucky.
David J VenzonBiostatistics and Data Management Section, NCI, Bethesda, Maryland.
Stefan BrennerDepartment of Clinical Pharmacy and Diagnostics, University of Vienna, Vienna, Austria.
Wooin LeeCollege of Pharmacy, Seoul National University, Seoul, Korea.
Maria MerinoTranslational Surgical Pathology Section, NCI, Bethesda, Maryland.
Ji LuoLaboratory of Cancer Biology and Genetics, NCI, Bethesda, Maryland.
Walter JagerDepartment of Clinical Pharmacy and Diagnostics, University of Vienna, Vienna, Austria.
Douglas K PriceMolecular Pharmacology Section, Genitourinary Malignancies Branch, NCI, Bethesda, Maryland.
Cindy H ChauMolecular Pharmacology Section, Genitourinary Malignancies Branch, NCI, Bethesda, Maryland.
William D FiggClinical Pharmacology Program, Office of the Clinical Director, NCI, Bethesda, Maryland. wf13e@nih.gov.
University of Kentucky · US

Funding

Drug Development for Prostate Cancer and other Metastatic ProcessesZIABC010547 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI FIGG, WILLIAM DOUGLAS · 2009 to 2025
$10.2M
New shRNA vectors for mammalian genetic analysisZIABC011304 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI LUO, JI · 2010 to 2025
$2.4M
Intramural NIH HHS ZIA BC010547
6 · The paper itself

Abstract

Castration-resistant prostate cancer (CRPC) has greater intratumoral testosterone concentrations than similar tumors from eugonadal men; simple diffusion does not account for this observation. This study was undertaken to ascertain the androgen uptake kinetics, functional, and clinical relevance of

Indexed as

AndrogensAnimalsCell Line, TumorGene Expression Regulation, NeoplasticHumansMaleMice, KnockoutProstateProstatic Neoplasms, Castration-ResistantRNA, Small InterferingSolute Carrier Organic Anion Transporter Family Member 1B3TestosteroneAndrogensRNA, Small InterferingSolute Carrier Organic Anion Transporter Family Member 1B3Testosterone

Identifiers

PMID28389619
PMCPMC5540879
OpenAlexW2604764972

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.