Evidence map›Paper›PMID 28389591›Full record

ArticleJournal of immunology (Baltimore, Md. : 1950)2017

CD11c-Expressing Cells Affect Regulatory T Cell Behavior in the Meninges during Central Nervous System Infection.

Carleigh A O'Brien, Christopher Overall, Christoph Konradt, Aisling C O'Hara Hall, Nikolas W Hayes, Sagie Wagage, Beena John, David A Christian, Christopher A Hunter, Tajie H Harris

Abstract read
In one paragraph

Article in Journal of immunology (Baltimore, Md. : 1950), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Article
  6. Review
  7. Review
  8. Impact of aging on meningeal gene expression.Fluids and barriers of the CNS · 2023
    Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Review
  15. Article
  16. Review
  17. Phenotypic and Functional Diversity in Regulatory T Cells.Frontiers in cell and developmental biology · 2021
    Review
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Carleigh A O'BrienCenter for Brain Immunology and Glia, Department of Neuroscience, University of Virginia, Charlottesville, VA 22908; and.
Christopher OverallCenter for Brain Immunology and Glia, Department of Neuroscience, University of Virginia, Charlottesville, VA 22908; and.
Christoph KonradtDepartment of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104.
Aisling C O'Hara HallDepartment of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104.
Nikolas W HayesCenter for Brain Immunology and Glia, Department of Neuroscience, University of Virginia, Charlottesville, VA 22908; and.ORCID 0000-0003-1885-1850
Sagie WagageDepartment of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104.
Beena JohnDepartment of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104.
David A ChristianDepartment of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104.
Christopher A HunterDepartment of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104.
Tajie H HarrisCenter for Brain Immunology and Glia, Department of Neuroscience, University of Virginia, Charlottesville, VA 22908; and tajieharris@virginia.edu.

Funding

Women's Oncology Program - WONP30CA044579 · NCI · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI Thomas P. Loughran · 1987 to 2026
$72.1M
INTERDISCIPLINARY TRAINING PROGRAM IN IMMUNOLOGYT32AI007496 · NIAID · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI Michael G. Brown, Coleen A McNamara · 1995 to 2026
$10.2M
IMMUNOPATHOGENESIS OF TOXOPLASMIC ENCEPHALITISR01AI041158 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI HUNTER, CHRISTOPHER A · 1996 to 2019
$4.8M
IL-27 and Treg cellsR01AI110201 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI HUNTER, CHRISTOPHER A · 2014 to 2018
$2.0M
Regulatory T cell responses in T. gondii infection of the brainR01NS091067 · NINDS · UNIVERSITY OF VIRGINIA · PI HARRIS, TAJIE H. · 2015 to 2019
$1.8M
NCI NIH HHS P30 CA044579NIAID NIH HHS R01 AI041158NIAID NIH HHS R01 AI110201NIAID NIH HHS T32 AI007496NINDS NIH HHS R01 NS091067
6 · The paper itself

Abstract

Regulatory T cells (Tregs) play an important role in the CNS during multiple infections, as well as autoimmune inflammation, but the behavior of this cell type in the CNS has not been explored. In mice, infection with

Indexed as

AnimalsCD11c AntigenCD4-Positive T-LymphocytesCell MovementIntravital MicroscopyLymphocyte ActivationMeningesMiceReceptors, Antigen, T-CellTh1 CellsT-Lymphocytes, RegulatoryToxoplasmaToxoplasmosis, CerebralCD11c AntigenReceptors, Antigen, T-Cell

Identifiers

PMID28389591
PMCPMC5451665

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.