Evidence map›Paper›PMID 28389580›Full record

ArticleJournal of cell science2017

The MgcRacGAP SxIP motif tethers Centralspindlin to microtubule plus ends in

Elaina B Breznau, Megan Murt, T Lynne Blasius, Kristen J Verhey, Ann L Miller

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cell science, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.3field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Review
  6. Article
  7. Nine unanswered questions about cytokinesis.The Journal of cell biology · 2017
    Review
  8. Ann Miller: Shaping cells and scientists.The Journal of cell biology · 2017
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Elaina B BreznauProgram in Cellular and Molecular Biology, University of Michigan, Ann Arbor, MI 48109, USA.
Megan MurtDepartment of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, MI 48109, USA.
T Lynne BlasiusDepartment of Cell and Developmental Biology, University of Michigan, Ann Arbor, MI 48109, USA.
Kristen J VerheyDepartment of Cell and Developmental Biology, University of Michigan, Ann Arbor, MI 48109, USA.
Ann L MillerProgram in Cellular and Molecular Biology, University of Michigan, Ann Arbor, MI 48109, USA annlm@umich.edu.ORCID 0000-0002-7293-764X
University of Michigan · US

Funding

CELLULAR AND MOLECULAR BIOLOGY AT MICHIGANT32GM007315 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI PUTHENVEEDU, MANOJKUMAR A · 1985 to 2021
$12.8M
Transient cytoskeletal arraysR01GM052932 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI BEMENT, WILLIAM · 1997 to 2023
$7.2M
Regulation of the molecular motor kinesin-IR01GM070862 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI VERHEY, KRISTEN J. · 2005 to 2018
$4.2M
Regulation of localized RhoA activity in dividing epithelial cellsR01GM112794 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MILLER, ANN LOUISE · 2015 to 2023
$3.0M
Regulation of Cytokinesis and Tumor Formation by RhoAR00GM089765 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MILLER, ANN LOUISE · 2011 to 2013
$727k
NIGMS NIH HHS R00 GM089765NIGMS NIH HHS R01 GM052932NIGMS NIH HHS R01 GM070862NIGMS NIH HHS R01 GM112794NIGMS NIH HHS T32 GM007315
6 · The paper itself

Abstract

Centralspindlin, a complex of the kinesin-6-family member MKLP1 and MgcRacGAP (also known as Kif23 and Racgap1, respectively), is required for cytokinesis and cell-cell junctions. During anaphase, Centralspindlin accumulates at overlapping central spindle microtubules and directs contractile ring formation by recruiting the GEF Ect2 to the cell equator to activate RhoA. We found that MgcRacGAP localized to the plus ends of equatorial astral microtubules during cytokinesis in

Indexed as

ActinsAdherens JunctionsAmino Acid MotifsAmino Acid SequenceAnimalsChlorocebus aethiopsCOS CellsCytokinesisGTPase-Activating ProteinsMicrotubulesModels, BiologicalMutationrhoA GTP-Binding ProteinStructure-Activity RelationshipTime-Lapse ImagingXenopus laevisActinsGTPase-Activating ProteinsmgcRacGAPrhoA GTP-Binding ProteinXenopus ProteinsCell–cell junctionsCentralspindlinCytokinesisMicrotubulesSxIP motifXenopus laevis

Identifiers

PMID28389580
PMCPMC5450188
OpenAlexW2604736410

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.