Trial reportCirculation2017
Prognostic Value of Noninvasive Cardiovascular Testing in Patients With Stable Chest Pain: Insights From the PROMISE Trial (Prospective Multicenter Imaging Study for Evaluation of Chest Pain).
Registry-linked trialOpen access · bronzeAbstract readComparative StudyMulticenter StudyRandomized Controlled Trial
In one paragraph
Trial report in Circulation, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01174550 (PROspective Multicenter Imaging Study for Evaluation of Chest Pain - The PROMISE Trial), which is not on this map. Cited by 207 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
207citing papers in PubMed, 1 pooled it
33.6field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
PROspective Multicenter Imaging Study for Evaluation of Chest Pain - The PROMISE Trial
Who cites it
207 citing papers in PubMed, 1 synthesis or guideline pooled it, 438 citations in OpenAlex.
- Prognostic value of coronary computed tomography angiographic derived fractional flow reserve: a systematic review and meta-analysis.Heart (British Cardiac Society) · 2022Pooled it
- A validated, modifiable proteomic score from the EXSCEL trial predicts cardiovascular events in diabetes.JCI insight · 2026Trial
- Survival After Initial Stress Testing vs Anatomic Testing in Suspected Coronary Artery Disease: Long-Term Follow-Up of the PROMISE Randomized Clinical Trial.JAMA cardiology · 2025Trial
- Stress Echocardiography in Patients With Moderate or Severe Myocardial Ischemia: Insights From the ISCHEMIA Trial.Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography · 2025Trial
- Sex Differences in Computed Tomography Coronary Stenosis Severity Versus Flow Impairment and Impact on Revascularization, Clinical Events and Health Care Costs: A FORECAST Substudy.Journal of the American Heart Association · 2025Trial
- Clinical risk prediction, coronary computed tomography angiography, and cardiovascular events in new-onset chest pain: the PROMISE and SCOT-HEART trials.European heart journal · 2025Trial
- Objective Ischemia, Subjective Angina, and Psychological Distress in Angina With No Obstructive Coronary Disease.Journal of the American Heart Association · 2024Trial
- Impact of smoking in patients with suspected coronary artery disease in the randomised DISCHARGE trial.European radiology · 2024Trial
- Impact of coronary CT angiography in selection of treatment modalities and subsequent cardiovascular events in Thai patients with stable CAD.Clinical research in cardiology : official journal of the German Cardiac Society · 2024Trial
- Coronary Atherosclerosis, Cardiac Troponin, and Interleukin-6 in Patients With Chest Pain: The PROMISE Trial Results.JACC. Cardiovascular imaging · 2022Trial
- Predictors of outcome in the ISCHEMIA-CKD trial: Anatomy versus ischemia.American heart journal · 2022Trial
- Fractional flow reserve derived from computed tomography coronary angiography in the assessment and management of stable chest pain: the FORECAST randomized trial.European heart journal · 2021Trial
- Outcomes in the ISCHEMIA Trial Based on Coronary Artery Disease and Ischemia Severity.Circulation · 2021Trial
- Cost-effectiveness Analysis of Anatomic vs Functional Index Testing in Patients With Low-Risk Stable Chest Pain.JAMA network open · 2020Trial
- Concomitant screening of coronary artery disease and lung cancer with a new ultrafast-low-dose Computed Tomography protocol: A pilot randomised trial.Scientific reports · 2019Trial
- High-Sensitivity Troponin I and Coronary Computed Tomography in Symptomatic Outpatients With Suspected CAD: Insights From the PROMISE Trial.JACC. Cardiovascular imaging · 2019Trial
- Pretest probability for patients with suspected obstructive coronary artery disease: re-evaluating Diamond-Forrester for the contemporary era and clinical implications: insights from the PROMISE trial.European heart journal. Cardiovascular Imaging · 2019Trial
- Stress Testing Versus CT Angiography in Patients With Diabetes and Suspected Coronary Artery Disease.Journal of the American College of Cardiology · 2019Trial
- Coronary Artery Plaque Characteristics Associated With Adverse Outcomes in the SCOT-HEART Study.Journal of the American College of Cardiology · 2019 · on this mapTrial
- Trial
147 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
20 authors at 1 institution in 1 country.
Udo HoffmannFrom Massachusetts General Hospital, Harvard Medical School, Boston (U.H., M.H.P.); Knight Cardiovascular Institute, Oregon Health and Science University, Portland (M.F.); Tufts University School of Medicine and the CardioVascular Center, Tufts Medical Center, Boston, MA (J.E.U.); Dalio Institute of Cardiovascular Imaging, New York-Presbyterian Hospital and Weill Cornell Medical College (Q.A.T.); Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC (M.R.P., M.H., M.P., D.B.M., C.B.F., A.S.K., K.L.L., P.S.D.); Cardiovascular Research, New York Methodist Hospital, Brooklyn (J.F.H.); Mayo Clinic, Rochester, MN (P.A.P.); Montreal Heart Institute, Université de Montréal, Canada (J.-C.T.); Los Angeles Biomedical Research Institute, Torrance, CA (M.B.); Cardiology, Beaumont Hospital-Dearborn, MI (G.N.); and Department of Medicine, Ottawa Heart Institute, Ontario, Canada (B.C.). uhoffmann@mgh.harvard.edu.
Maros FerencikFrom Massachusetts General Hospital, Harvard Medical School, Boston (U.H., M.H.P.); Knight Cardiovascular Institute, Oregon Health and Science University, Portland (M.F.); Tufts University School of Medicine and the CardioVascular Center, Tufts Medical Center, Boston, MA (J.E.U.); Dalio Institute of Cardiovascular Imaging, New York-Presbyterian Hospital and Weill Cornell Medical College (Q.A.T.); Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC (M.R.P., M.H., M.P., D.B.M., C.B.F., A.S.K., K.L.L., P.S.D.); Cardiovascular Research, New York Methodist Hospital, Brooklyn (J.F.H.); Mayo Clinic, Rochester, MN (P.A.P.); Montreal Heart Institute, Université de Montréal, Canada (J.-C.T.); Los Angeles Biomedical Research Institute, Torrance, CA (M.B.); Cardiology, Beaumont Hospital-Dearborn, MI (G.N.); and Department of Medicine, Ottawa Heart Institute, Ontario, Canada (B.C.).
James E UdelsonFrom Massachusetts General Hospital, Harvard Medical School, Boston (U.H., M.H.P.); Knight Cardiovascular Institute, Oregon Health and Science University, Portland (M.F.); Tufts University School of Medicine and the CardioVascular Center, Tufts Medical Center, Boston, MA (J.E.U.); Dalio Institute of Cardiovascular Imaging, New York-Presbyterian Hospital and Weill Cornell Medical College (Q.A.T.); Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC (M.R.P., M.H., M.P., D.B.M., C.B.F., A.S.K., K.L.L., P.S.D.); Cardiovascular Research, New York Methodist Hospital, Brooklyn (J.F.H.); Mayo Clinic, Rochester, MN (P.A.P.); Montreal Heart Institute, Université de Montréal, Canada (J.-C.T.); Los Angeles Biomedical Research Institute, Torrance, CA (M.B.); Cardiology, Beaumont Hospital-Dearborn, MI (G.N.); and Department of Medicine, Ottawa Heart Institute, Ontario, Canada (B.C.).
Michael H PicardFrom Massachusetts General Hospital, Harvard Medical School, Boston (U.H., M.H.P.); Knight Cardiovascular Institute, Oregon Health and Science University, Portland (M.F.); Tufts University School of Medicine and the CardioVascular Center, Tufts Medical Center, Boston, MA (J.E.U.); Dalio Institute of Cardiovascular Imaging, New York-Presbyterian Hospital and Weill Cornell Medical College (Q.A.T.); Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC (M.R.P., M.H., M.P., D.B.M., C.B.F., A.S.K., K.L.L., P.S.D.); Cardiovascular Research, New York Methodist Hospital, Brooklyn (J.F.H.); Mayo Clinic, Rochester, MN (P.A.P.); Montreal Heart Institute, Université de Montréal, Canada (J.-C.T.); Los Angeles Biomedical Research Institute, Torrance, CA (M.B.); Cardiology, Beaumont Hospital-Dearborn, MI (G.N.); and Department of Medicine, Ottawa Heart Institute, Ontario, Canada (B.C.).
Quynh A TruongFrom Massachusetts General Hospital, Harvard Medical School, Boston (U.H., M.H.P.); Knight Cardiovascular Institute, Oregon Health and Science University, Portland (M.F.); Tufts University School of Medicine and the CardioVascular Center, Tufts Medical Center, Boston, MA (J.E.U.); Dalio Institute of Cardiovascular Imaging, New York-Presbyterian Hospital and Weill Cornell Medical College (Q.A.T.); Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC (M.R.P., M.H., M.P., D.B.M., C.B.F., A.S.K., K.L.L., P.S.D.); Cardiovascular Research, New York Methodist Hospital, Brooklyn (J.F.H.); Mayo Clinic, Rochester, MN (P.A.P.); Montreal Heart Institute, Université de Montréal, Canada (J.-C.T.); Los Angeles Biomedical Research Institute, Torrance, CA (M.B.); Cardiology, Beaumont Hospital-Dearborn, MI (G.N.); and Department of Medicine, Ottawa Heart Institute, Ontario, Canada (B.C.).
Manesh R PatelFrom Massachusetts General Hospital, Harvard Medical School, Boston (U.H., M.H.P.); Knight Cardiovascular Institute, Oregon Health and Science University, Portland (M.F.); Tufts University School of Medicine and the CardioVascular Center, Tufts Medical Center, Boston, MA (J.E.U.); Dalio Institute of Cardiovascular Imaging, New York-Presbyterian Hospital and Weill Cornell Medical College (Q.A.T.); Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC (M.R.P., M.H., M.P., D.B.M., C.B.F., A.S.K., K.L.L., P.S.D.); Cardiovascular Research, New York Methodist Hospital, Brooklyn (J.F.H.); Mayo Clinic, Rochester, MN (P.A.P.); Montreal Heart Institute, Université de Montréal, Canada (J.-C.T.); Los Angeles Biomedical Research Institute, Torrance, CA (M.B.); Cardiology, Beaumont Hospital-Dearborn, MI (G.N.); and Department of Medicine, Ottawa Heart Institute, Ontario, Canada (B.C.).
Megan HuangFrom Massachusetts General Hospital, Harvard Medical School, Boston (U.H., M.H.P.); Knight Cardiovascular Institute, Oregon Health and Science University, Portland (M.F.); Tufts University School of Medicine and the CardioVascular Center, Tufts Medical Center, Boston, MA (J.E.U.); Dalio Institute of Cardiovascular Imaging, New York-Presbyterian Hospital and Weill Cornell Medical College (Q.A.T.); Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC (M.R.P., M.H., M.P., D.B.M., C.B.F., A.S.K., K.L.L., P.S.D.); Cardiovascular Research, New York Methodist Hospital, Brooklyn (J.F.H.); Mayo Clinic, Rochester, MN (P.A.P.); Montreal Heart Institute, Université de Montréal, Canada (J.-C.T.); Los Angeles Biomedical Research Institute, Torrance, CA (M.B.); Cardiology, Beaumont Hospital-Dearborn, MI (G.N.); and Department of Medicine, Ottawa Heart Institute, Ontario, Canada (B.C.).
Michael PencinaFrom Massachusetts General Hospital, Harvard Medical School, Boston (U.H., M.H.P.); Knight Cardiovascular Institute, Oregon Health and Science University, Portland (M.F.); Tufts University School of Medicine and the CardioVascular Center, Tufts Medical Center, Boston, MA (J.E.U.); Dalio Institute of Cardiovascular Imaging, New York-Presbyterian Hospital and Weill Cornell Medical College (Q.A.T.); Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC (M.R.P., M.H., M.P., D.B.M., C.B.F., A.S.K., K.L.L., P.S.D.); Cardiovascular Research, New York Methodist Hospital, Brooklyn (J.F.H.); Mayo Clinic, Rochester, MN (P.A.P.); Montreal Heart Institute, Université de Montréal, Canada (J.-C.T.); Los Angeles Biomedical Research Institute, Torrance, CA (M.B.); Cardiology, Beaumont Hospital-Dearborn, MI (G.N.); and Department of Medicine, Ottawa Heart Institute, Ontario, Canada (B.C.).
Daniel B MarkFrom Massachusetts General Hospital, Harvard Medical School, Boston (U.H., M.H.P.); Knight Cardiovascular Institute, Oregon Health and Science University, Portland (M.F.); Tufts University School of Medicine and the CardioVascular Center, Tufts Medical Center, Boston, MA (J.E.U.); Dalio Institute of Cardiovascular Imaging, New York-Presbyterian Hospital and Weill Cornell Medical College (Q.A.T.); Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC (M.R.P., M.H., M.P., D.B.M., C.B.F., A.S.K., K.L.L., P.S.D.); Cardiovascular Research, New York Methodist Hospital, Brooklyn (J.F.H.); Mayo Clinic, Rochester, MN (P.A.P.); Montreal Heart Institute, Université de Montréal, Canada (J.-C.T.); Los Angeles Biomedical Research Institute, Torrance, CA (M.B.); Cardiology, Beaumont Hospital-Dearborn, MI (G.N.); and Department of Medicine, Ottawa Heart Institute, Ontario, Canada (B.C.).
John F HeitnerFrom Massachusetts General Hospital, Harvard Medical School, Boston (U.H., M.H.P.); Knight Cardiovascular Institute, Oregon Health and Science University, Portland (M.F.); Tufts University School of Medicine and the CardioVascular Center, Tufts Medical Center, Boston, MA (J.E.U.); Dalio Institute of Cardiovascular Imaging, New York-Presbyterian Hospital and Weill Cornell Medical College (Q.A.T.); Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC (M.R.P., M.H., M.P., D.B.M., C.B.F., A.S.K., K.L.L., P.S.D.); Cardiovascular Research, New York Methodist Hospital, Brooklyn (J.F.H.); Mayo Clinic, Rochester, MN (P.A.P.); Montreal Heart Institute, Université de Montréal, Canada (J.-C.T.); Los Angeles Biomedical Research Institute, Torrance, CA (M.B.); Cardiology, Beaumont Hospital-Dearborn, MI (G.N.); and Department of Medicine, Ottawa Heart Institute, Ontario, Canada (B.C.).
Christopher B FordyceFrom Massachusetts General Hospital, Harvard Medical School, Boston (U.H., M.H.P.); Knight Cardiovascular Institute, Oregon Health and Science University, Portland (M.F.); Tufts University School of Medicine and the CardioVascular Center, Tufts Medical Center, Boston, MA (J.E.U.); Dalio Institute of Cardiovascular Imaging, New York-Presbyterian Hospital and Weill Cornell Medical College (Q.A.T.); Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC (M.R.P., M.H., M.P., D.B.M., C.B.F., A.S.K., K.L.L., P.S.D.); Cardiovascular Research, New York Methodist Hospital, Brooklyn (J.F.H.); Mayo Clinic, Rochester, MN (P.A.P.); Montreal Heart Institute, Université de Montréal, Canada (J.-C.T.); Los Angeles Biomedical Research Institute, Torrance, CA (M.B.); Cardiology, Beaumont Hospital-Dearborn, MI (G.N.); and Department of Medicine, Ottawa Heart Institute, Ontario, Canada (B.C.).
Patricia A PellikkaFrom Massachusetts General Hospital, Harvard Medical School, Boston (U.H., M.H.P.); Knight Cardiovascular Institute, Oregon Health and Science University, Portland (M.F.); Tufts University School of Medicine and the CardioVascular Center, Tufts Medical Center, Boston, MA (J.E.U.); Dalio Institute of Cardiovascular Imaging, New York-Presbyterian Hospital and Weill Cornell Medical College (Q.A.T.); Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC (M.R.P., M.H., M.P., D.B.M., C.B.F., A.S.K., K.L.L., P.S.D.); Cardiovascular Research, New York Methodist Hospital, Brooklyn (J.F.H.); Mayo Clinic, Rochester, MN (P.A.P.); Montreal Heart Institute, Université de Montréal, Canada (J.-C.T.); Los Angeles Biomedical Research Institute, Torrance, CA (M.B.); Cardiology, Beaumont Hospital-Dearborn, MI (G.N.); and Department of Medicine, Ottawa Heart Institute, Ontario, Canada (B.C.).
Jean-Claude TardifFrom Massachusetts General Hospital, Harvard Medical School, Boston (U.H., M.H.P.); Knight Cardiovascular Institute, Oregon Health and Science University, Portland (M.F.); Tufts University School of Medicine and the CardioVascular Center, Tufts Medical Center, Boston, MA (J.E.U.); Dalio Institute of Cardiovascular Imaging, New York-Presbyterian Hospital and Weill Cornell Medical College (Q.A.T.); Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC (M.R.P., M.H., M.P., D.B.M., C.B.F., A.S.K., K.L.L., P.S.D.); Cardiovascular Research, New York Methodist Hospital, Brooklyn (J.F.H.); Mayo Clinic, Rochester, MN (P.A.P.); Montreal Heart Institute, Université de Montréal, Canada (J.-C.T.); Los Angeles Biomedical Research Institute, Torrance, CA (M.B.); Cardiology, Beaumont Hospital-Dearborn, MI (G.N.); and Department of Medicine, Ottawa Heart Institute, Ontario, Canada (B.C.).
Matthew BudoffFrom Massachusetts General Hospital, Harvard Medical School, Boston (U.H., M.H.P.); Knight Cardiovascular Institute, Oregon Health and Science University, Portland (M.F.); Tufts University School of Medicine and the CardioVascular Center, Tufts Medical Center, Boston, MA (J.E.U.); Dalio Institute of Cardiovascular Imaging, New York-Presbyterian Hospital and Weill Cornell Medical College (Q.A.T.); Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC (M.R.P., M.H., M.P., D.B.M., C.B.F., A.S.K., K.L.L., P.S.D.); Cardiovascular Research, New York Methodist Hospital, Brooklyn (J.F.H.); Mayo Clinic, Rochester, MN (P.A.P.); Montreal Heart Institute, Université de Montréal, Canada (J.-C.T.); Los Angeles Biomedical Research Institute, Torrance, CA (M.B.); Cardiology, Beaumont Hospital-Dearborn, MI (G.N.); and Department of Medicine, Ottawa Heart Institute, Ontario, Canada (B.C.).
George NahhasFrom Massachusetts General Hospital, Harvard Medical School, Boston (U.H., M.H.P.); Knight Cardiovascular Institute, Oregon Health and Science University, Portland (M.F.); Tufts University School of Medicine and the CardioVascular Center, Tufts Medical Center, Boston, MA (J.E.U.); Dalio Institute of Cardiovascular Imaging, New York-Presbyterian Hospital and Weill Cornell Medical College (Q.A.T.); Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC (M.R.P., M.H., M.P., D.B.M., C.B.F., A.S.K., K.L.L., P.S.D.); Cardiovascular Research, New York Methodist Hospital, Brooklyn (J.F.H.); Mayo Clinic, Rochester, MN (P.A.P.); Montreal Heart Institute, Université de Montréal, Canada (J.-C.T.); Los Angeles Biomedical Research Institute, Torrance, CA (M.B.); Cardiology, Beaumont Hospital-Dearborn, MI (G.N.); and Department of Medicine, Ottawa Heart Institute, Ontario, Canada (B.C.).
Benjamin ChowFrom Massachusetts General Hospital, Harvard Medical School, Boston (U.H., M.H.P.); Knight Cardiovascular Institute, Oregon Health and Science University, Portland (M.F.); Tufts University School of Medicine and the CardioVascular Center, Tufts Medical Center, Boston, MA (J.E.U.); Dalio Institute of Cardiovascular Imaging, New York-Presbyterian Hospital and Weill Cornell Medical College (Q.A.T.); Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC (M.R.P., M.H., M.P., D.B.M., C.B.F., A.S.K., K.L.L., P.S.D.); Cardiovascular Research, New York Methodist Hospital, Brooklyn (J.F.H.); Mayo Clinic, Rochester, MN (P.A.P.); Montreal Heart Institute, Université de Montréal, Canada (J.-C.T.); Los Angeles Biomedical Research Institute, Torrance, CA (M.B.); Cardiology, Beaumont Hospital-Dearborn, MI (G.N.); and Department of Medicine, Ottawa Heart Institute, Ontario, Canada (B.C.).
Andrzej S KosinskiFrom Massachusetts General Hospital, Harvard Medical School, Boston (U.H., M.H.P.); Knight Cardiovascular Institute, Oregon Health and Science University, Portland (M.F.); Tufts University School of Medicine and the CardioVascular Center, Tufts Medical Center, Boston, MA (J.E.U.); Dalio Institute of Cardiovascular Imaging, New York-Presbyterian Hospital and Weill Cornell Medical College (Q.A.T.); Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC (M.R.P., M.H., M.P., D.B.M., C.B.F., A.S.K., K.L.L., P.S.D.); Cardiovascular Research, New York Methodist Hospital, Brooklyn (J.F.H.); Mayo Clinic, Rochester, MN (P.A.P.); Montreal Heart Institute, Université de Montréal, Canada (J.-C.T.); Los Angeles Biomedical Research Institute, Torrance, CA (M.B.); Cardiology, Beaumont Hospital-Dearborn, MI (G.N.); and Department of Medicine, Ottawa Heart Institute, Ontario, Canada (B.C.).
Kerry L LeeFrom Massachusetts General Hospital, Harvard Medical School, Boston (U.H., M.H.P.); Knight Cardiovascular Institute, Oregon Health and Science University, Portland (M.F.); Tufts University School of Medicine and the CardioVascular Center, Tufts Medical Center, Boston, MA (J.E.U.); Dalio Institute of Cardiovascular Imaging, New York-Presbyterian Hospital and Weill Cornell Medical College (Q.A.T.); Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC (M.R.P., M.H., M.P., D.B.M., C.B.F., A.S.K., K.L.L., P.S.D.); Cardiovascular Research, New York Methodist Hospital, Brooklyn (J.F.H.); Mayo Clinic, Rochester, MN (P.A.P.); Montreal Heart Institute, Université de Montréal, Canada (J.-C.T.); Los Angeles Biomedical Research Institute, Torrance, CA (M.B.); Cardiology, Beaumont Hospital-Dearborn, MI (G.N.); and Department of Medicine, Ottawa Heart Institute, Ontario, Canada (B.C.).
Pamela S DouglasFrom Massachusetts General Hospital, Harvard Medical School, Boston (U.H., M.H.P.); Knight Cardiovascular Institute, Oregon Health and Science University, Portland (M.F.); Tufts University School of Medicine and the CardioVascular Center, Tufts Medical Center, Boston, MA (J.E.U.); Dalio Institute of Cardiovascular Imaging, New York-Presbyterian Hospital and Weill Cornell Medical College (Q.A.T.); Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC (M.R.P., M.H., M.P., D.B.M., C.B.F., A.S.K., K.L.L., P.S.D.); Cardiovascular Research, New York Methodist Hospital, Brooklyn (J.F.H.); Mayo Clinic, Rochester, MN (P.A.P.); Montreal Heart Institute, Université de Montréal, Canada (J.-C.T.); Los Angeles Biomedical Research Institute, Torrance, CA (M.B.); Cardiology, Beaumont Hospital-Dearborn, MI (G.N.); and Department of Medicine, Ottawa Heart Institute, Ontario, Canada (B.C.).
PROMISE Investigators
Tufts Medical Center · US
Funding
PROMISE Trial: Clinical Coordinating CenterR01HL098237 · NHLBI · DUKE UNIVERSITY · PI DOUGLAS, PAMELA SUSAN · 2009 to 2014
$27.3MPROMISE Trial: SDCCR01HL098236 · NHLBI · DUKE UNIVERSITY · PI LEE, KERRY L · 2009 to 2014
$5.0MPROMISE Trial: Dx CoreR01HL098305 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI HOFFMANN, UDO · 2009 to 2014
$3.5MPROMISE Trial: EQOL Coordinating CenterR01HL098235 · NHLBI · DUKE UNIVERSITY · PI MARK, DANIEL B · 2009 to 2014
$1.6MCardiovascular Imaging in Ischemic Heart DiseaseK24HL113128 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI HOFFMANN, UDO · 2012 to 2020
$1.1MNHLBI NIH HHS K24 HL113128NHLBI NIH HHS R01 HL098235NHLBI NIH HHS R01 HL098236NHLBI NIH HHS R01 HL098237NHLBI NIH HHS R01 HL098305
Abstract
backgroundOptimal management of patients with stable chest pain relies on the prognostic information provided by noninvasive cardiovascular testing, but there are limited data from randomized trials comparing anatomic with functional testing.
methodsIn the PROMISE trial (Prospective Multicenter Imaging Study for Evaluation of Chest Pain), patients with stable chest pain and intermediate pretest probability for obstructive coronary artery disease (CAD) were randomly assigned to functional testing (exercise electrocardiography, nuclear stress, or stress echocardiography) or coronary computed tomography angiography (CTA). Site-based diagnostic test reports were classified as normal or mildly, moderately, or severely abnormal. The primary end point was death, myocardial infarction, or unstable angina hospitalizations over a median follow-up of 26.1 months.
resultsBoth the prevalence of normal test results and incidence rate of events in these patients were significantly lower among 4500 patients randomly assigned to CTA in comparison with 4602 patients randomly assigned to functional testing (33.4% versus 78.0%, and 0.9% versus 2.1%, respectively; both
conclusionsCoronary CTA, by identifying patients at risk because of nonobstructive CAD, provides better prognostic information than functional testing in contemporary patients who have stable chest pain with a low burden of obstructive CAD, myocardial ischemia, and events. CLINICAL
trial registrationURL: http://www.clinicaltrials.gov. Unique identifier: NCT01174550.
Indexed as
AgedChest PainCoronary AngiographyCoronary Artery DiseaseEchocardiography, StressExercise TestFemaleFollow-Up StudiesHumansMaleMiddle AgedPrognosisProspective StudiesTomography, X-Ray Computedcoronary artery diseasediagnostic tests, routineprognosis
Identifiers
What OpenQuestion holds
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Registered trials
NCT01174550ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.