ArticleGut2017
BVES regulates c-Myc stability via PP2A and suppresses colitis-induced tumourigenesis.
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Article in Gut, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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32citing papers in PubMed
3.0field-weighted citation impact, top 10% of its field
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Who cites it
32 citing papers in PubMed, 70 citations in OpenAlex.
- DNA hypermethylation drives BVES-mediated autophagy to promote cisplatin resistance in lung adenocarcinoma.Journal of bioenergetics and biomembranes · 2026Article
- Epigenetic Landscapes in Ulcerative Colitis: From Mechanistic Insights to Clinical Translation.ACS omega · 2025Review
- TheBiology · 2025Article
- Multiomic spatial atlas shows deleted in malignant brain tumors 1 (DMBT1) glycoprotein is lost in colonic dysplasia.The Journal of pathology · 2025Article
- cAMP-PKA/EPAC signaling and cancer: the interplay in tumor microenvironment.Journal of hematology & oncology · 2024Review
- GABA induced by sleep deprivation promotes the proliferation and migration of colon tumors through miR-223-3p endogenous pathway and exosome pathway.Journal of experimental & clinical cancer research : CR · 2023Article
- MBNL1‑AS1 attenuates tumor cell proliferation by regulating the miR‑29c‑3p/BVES signal in colorectal cancer.Oncology reports · 2023Article
- Mice Lacking the cAMP Effector Protein POPDC1 Show Enhanced Hippocampal Synaptic Plasticity.Cerebral cortex (New York, N.Y. : 1991) · 2022Article
- Review
- Therapeutic targets and pharmacological mechanisms ofFrontiers in pharmacology · 2022Article
- Integrated analysis of bulk and single-cell RNA-seq reveals the role of MYC signaling in lung adenocarcinoma.Frontiers in genetics · 2022Article
- Identification of the effect and mechanism of Yiyi Fuzi Baijiang powder against colorectal cancer using network pharmacology and experimental validation.Frontiers in pharmacology · 2022Article
- DNA Methylation Profiling of MYC, SMAD2/3 and DNMT3A in Colorectal Cancer.Oman medical journal · 2021Review
- Predicting Colorectal Cancer Occurrence in IBD.Cancers · 2021Review
- The Transition from Gastric Intestinal Metaplasia to Gastric Cancer InvolvesInternational journal of molecular sciences · 2021Article
- The Function and Prognostic Value of RNA-Binding Proteins in Colorectal Adenocarcinoma Were Analyzed Based on Bioinformatics of Smart Medical Big Data.Journal of healthcare engineering · 2021Article
- An interaction of heart disease-associated proteins POPDC1/2 with XIRP1 in transverse tubules and intercalated discs.BMC molecular and cell biology · 2020Article
- The prognostic role of c-MYC amplification in schistosomiasis-associated colorectal cancer.Japanese journal of clinical oncology · 2020Article
- Review
- Review
Corrections and comments
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Authors and funding
20 authors at 7 institutions in 2 countries.
Bobak ParangDivision of Gastroenterology, Department of Medicine, Vanderbilt University, Nashville, Tennessee, USA.
Andrew M KazGastroenterology Section, VA Puget Sound Health Care System, Seattle, Washington, USA.
Caitlyn W BarrettDivision of Gastroenterology, Department of Medicine, Vanderbilt University, Nashville, Tennessee, USA.
Sarah P ShortDivision of Gastroenterology, Department of Medicine, Vanderbilt University, Nashville, Tennessee, USA.
Wei NingDivision of Gastroenterology, Department of Medicine, Vanderbilt University, Nashville, Tennessee, USA.
Cody E KeatingDivision of Gastroenterology, Department of Medicine, Vanderbilt University, Nashville, Tennessee, USA.
Mukul K MittalDivision of Gastroenterology, Department of Medicine, Vanderbilt University, Nashville, Tennessee, USA.
Rishi D NaikDivision of Gastroenterology, Department of Medicine, Vanderbilt University, Nashville, Tennessee, USA.
Mary K WashingtonDepartment of Pathology, Microbiology, and Immunology, Vanderbilt University, Nashville, Tennessee, USA.
Frank L RevettaDepartment of Pathology, Microbiology, and Immunology, Vanderbilt University, Nashville, Tennessee, USA.
J Joshua SmithDepartment of Surgery, Colorectal Service, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Xi ChenDivision of Biostatistics, Department of Public Health Sciences, University of Miami Miller School of Medicine, Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, USA.
Keith T WilsonDivision of Gastroenterology, Department of Medicine, Vanderbilt University, Nashville, Tennessee, USA.
Thomas BrandHeart Science Centre, National Heart and Lung Institute, Imperial College of London, London, UK.
David M BaderDepartment of Cell and Developmental Biology, Vanderbilt University, Nashville, Tennessee, USA.
William P TanseyVanderbilt Ingram Cancer Center, Nashville, Tennessee, USA.
Ru ChenDivision of Gastroenterology, Department of Medicine, University of Washington, Seattle, Washington, USA.
Teresa A BrentnallDivision of Gastroenterology, Department of Medicine, University of Washington, Seattle, Washington, USA.
William M GradyDivision of Gastroenterology, Department of Medicine, University of Washington, Seattle, Washington, USA.
Christopher S WilliamsDivision of Gastroenterology, Department of Medicine, Vanderbilt University, Nashville, Tennessee, USA.
Vanderbilt University · USUniversity of Washington · USVanderbilt-Ingram Cancer CenterImperial College London · GBMemorial Sloan Kettering Cancer Center · USSylvester Comprehensive Cancer Center · USVA Puget Sound Health Care System · US
Funding
X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4MUnderstanding and Controlling p120 Dysfunction in CRCP50CA095103 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI COFFEY, ROBERT J. · 2002 to 2017
$33.6MTranslational Analysis CoreP30DK058404 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI RICHARD M. PEEK · 2002 to 2026
$29.9MMEDICAL SCIENTIST TRAINING PROGRAMT32GM007347 · NIGMS · VANDERBILT UNIVERSITY · PI WILLIAMS, CHRISTOPHER S. · 1985 to 2023
$26.3MProject 3 - Molecular Signatures of Gastric Carcinogenesis in the Host Response to H. pyloriP01CA028842 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI WILSON, KEITH T. · 1985 to 2019
$15.8MImmunomodulatory effects of arginine supplementation in colitis and colon cancerR01AT004821 · NCCIH · VANDERBILT UNIVERSITY MEDICAL CENTER · PI WILSON, KEITH T. · 2008 to 2017
$4.0MFacilitated recruitment of MYC to chromatin by interaction with WDR5R01CA200709 · NCI · VANDERBILT UNIVERSITY · PI TANSEY, WILLIAM PATRICK · 2016 to 2025
$3.9MHPYLORI INDUCED DNA DAMAGE AND IMMUNE DYSREGULATIONR01DK053620 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI WILSON, KEITH T. · 1997 to 2014
$3.4MTargeted chemoprevention of gastric carcinogenesis in high risk populationsR01CA190612 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI MORGAN, DOUGLAS, WILSON, KEITH T. · 2014 to 2018
$3.0MSelenium in gastrointestinal inflammatory diseasesR01DK099204 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI WILLIAMS, CHRISTOPHER S. · 2014 to 2018
$1.8MThe role of MTGR1 in intestinal biology and inflammationK08DK080221 · NIDDK · VANDERBILT UNIVERSITY · PI WILLIAMS, CHRISTOPHER S. · 2008 to 2012
$705kLSM880-Airyscan Confocal Microscope for Large Shared ResourceS10OD021630 · OD · VANDERBILT UNIVERSITY · PI WELLS, K. SAM · 2016 to 2016
$560kBLRD VA I01 BX001426BLRD VA I01 BX001453Medical Research Council MR/J010383/J1NCCIH NIH HHS R01 AT004821NCI NIH HHS P01 CA028842NCI NIH HHS P30 CA008748NCI NIH HHS P50 CA095103NCI NIH HHS R01 CA190612NCI NIH HHS R01 CA200709NIDDK NIH HHS F30 DK096718NIDDK NIH HHS K08 DK080221NIDDK NIH HHS P30 DK058404NIDDK NIH HHS R01 DK053620NIDDK NIH HHS R01 DK099204NIGMS NIH HHS T32 GM007347NIH HHS S10 OD021630
Abstract
objectiveBlood vessel epicardial substance (BVES) is a tight junction-associated protein that regulates epithelial-mesenchymal states and is underexpressed in epithelial malignancy. However, the functional impact of BVES loss on tumourigenesis is unknown. Here we define the in vivo role of BVES in colitis-associated cancer (CAC), its cellular function and its relevance to patients with IBD.
designWe determined
results
conclusionLoss of BVES promotes inflammatory tumourigenesis through dysregulation of Wnt signalling and the oncogene c-Myc.
Indexed as
AnimalsBiomarkers, TumorCaco-2 CellsCarcinogenesisCell Adhesion MoleculesColitisColitis, UlcerativeColonColonic NeoplasmsDextran SulfateDNA MethylationDown-RegulationFemaleGene Expression ProfilingHEK293 CellsHumansBiomarkers, TumorBves protein, mouseCell Adhesion MoleculesDextran SulfateMembrane ProteinsMuscle ProteinsPOPDC1 protein, humanPpp2r5a protein, mouseProtein Phosphatase 2Proto-Oncogene Proteins c-mycRNA, MessengerCANCERCOLONIC NEOPLASMSCOLORECTAL CANCERIBDULCERATIVE COLITIS
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.