Evidence map›Paper›PMID 28389525›Full record

ReviewPhysiological genomics2017

Role of renal transporters and novel regulatory interactions in the TAL that control blood pressure.

Lesley A Graham, Anna F Dominiczak, Nicholas R Ferreri

Abstract readReview
In one paragraph

Review in Physiological genomics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.3field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 14 citations in OpenAlex.

  1. Trial
  2. Article
  3. Review
  4. Review
  5. The importance of the thick ascending limb of Henle's loop in renal physiology and pathophysiology.International journal of nephrology and renovascular disease · 2018
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 2 countries.

Lesley A GrahamBHF Glasgow Cardiovascular Research Centre, University of Glasgow Cardiovascular and Medical Sciences, Glasgow, United Kingdom; and Lesley.Graham@glasgow.ac.uk.
Anna F DominiczakBHF Glasgow Cardiovascular Research Centre, University of Glasgow Cardiovascular and Medical Sciences, Glasgow, United Kingdom; and.
Nicholas R FerreriDepartment of Pharmacology, New York Medical College, Valhalla, New York.
University of Glasgow · GBNew York Medical College · US

Funding

British Heart Foundation CS/16/1/31878British Heart Foundation PG/12/85/29925
6 · The paper itself

Abstract

Hypertension (HTN), a major public health issue is currently the leading factor in the global burden of disease, where associated complications account for 9.4 million deaths worldwide every year. Excessive dietary salt intake is among the environmental factors that contribute to HTN, known as salt sensitivity. The heterogeneity of salt sensitivity and the multiple mechanisms that link high salt intake to increases in blood pressure are of upmost importance for therapeutic application. A continual increase in the kidney's reabsorption of sodium (Na

Indexed as

AnimalsAnion Transport ProteinsBiological TransportBlood PressureCation Transport ProteinsHumansHypertensionLoop of HenleSodium-Hydrogen Exchanger 3Solute Carrier Family 12, Member 1UromodulinAnion Transport ProteinsCation Transport ProteinsSLC9A3 protein, humanSodium-Hydrogen Exchanger 3Solute Carrier Family 12, Member 1Uromodulinhypertensionsalt sensitivitysodium, kidneythick ascending limb of the loop of Henle

Identifiers

PMID28389525
PMCPMC5451551
OpenAlexW2604672845

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.