ArticleArchives of disease in childhood. Fetal and neonatal edition2017
Management and investigation of neonatal encephalopathy: 2017 update.
Article in Archives of disease in childhood. Fetal and neonatal edition, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 85 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Use of Melatonin for Neuroprotection in Term Infants With Hypoxic-ischaemic Encephalopathy
Autophagy, Mitophagy, Inflammation and Plasmatic Concentration of Melatonin in Newborn With Metabolic Acidosis at Birth
Who cites it
85 citing papers in PubMed, 5 syntheses or guidelines pooled it, 197 citations in OpenAlex.
- Pooled it
- Prognostic Value of Clinical Tests in Neonates With Hypoxic-Ischemic Encephalopathy Treated With Therapeutic Hypothermia: A Systematic Review and Meta-Analysis.Frontiers in neurology · 2020Pooled it
- Severity of hypoxic ischemic encephalopathy and heart rate variability in neonates: a systematic review.BMC pediatrics · 2019Pooled it
- Comparative Efficacy and Safety of Neuroprotective Therapies for Neonates With Hypoxic Ischemic Encephalopathy: A Network Meta-Analysis.Frontiers in pharmacology · 2019Pooled it
- Neonatal Encephalopathy With Group B Streptococcal Disease Worldwide: Systematic Review, Investigator Group Datasets, and Meta-analysis.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2017Pooled it
- Vitamin D as an Adjuvant Therapy in Neonatal Hypoxia: Is it Beneficial?Endocrine, metabolic & immune disorders drug targets · 2019Trial
- Does fluid restriction improve outcomes in infants with hypoxic ischemic encephalopathy? A pilot randomized controlled trial.Journal of perinatology : official journal of the California Perinatal Association · 2018Trial
- Temporal profile of serum orexin-A in neonatal hypoxic-ischemic encephalopathy: a prospective longitudinal study.BMC pediatrics · 2026Observational
- Cross-species evidence for cardiolipin remodeling in neonatal hypoxic-ischemic encephalopathy.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2026Article
- Neonatal neurocritical care considerations for prenatally identified neurological disorders.Pediatric research · 2026Review
- Diffusion tensor imaging and MR spectroscopy in the evaluation of neonatal encephalopathies.Journal of neonatal-perinatal medicine · 2026Article
- Long-Term Neurodevelopmental Outcomes and Prognostic Factors in Neonates with Hypoxic-Ischemic Encephalopathy.Journal of clinical medicine · 2026Article
- Article
- Cognitive development at late infancy and school age in children cooled for neonatal encephalopathy.Pediatric research · 2026Article
- Editorial: Evaluating efficacy and outcomes in neonatal HIE treatment: A global perspective.Frontiers in pediatrics · 2026Article
- Neonatal encephalopathy and hypoxic-ischemic encephalopathy: the state of the art.Pediatric research · 2025Review
- Challenging Mild Hypoxic-Ischemic Encephalopathy: Insights Into Neurological Outcomes.Turkish archives of pediatrics · 2025Article
- Current progress and future prospects of machine learning in the diagnosis of neonatal encephalopathy: a narrative review.Translational pediatrics · 2025Review
- Current Knowledge of Neonatal Birth Asphyxia - a Review of Recent Literature and Novel Approach.Maedica · 2025Review
- Review of Precision Medicine and Diagnosis of Neonatal Illness.Diagnostics (Basel, Switzerland) · 2025Review
25 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
This review discusses an approach to determining the cause of neonatal encephalopathy, as well as current evidence on resuscitation and subsequent management of hypoxic-ischaemic encephalopathy (HIE). Encephalopathy in neonates can be due to varied aetiologies in addition to hypoxic-ischaemia. A combination of careful history, examination and the judicious use of investigations can help determine the cause. Over the last 7 years, infants with moderate to severe HIE have benefited from the introduction of routine therapeutic hypothermia; the number needed to treat for an additional beneficial outcome is 7 (95% CI 5 to 10). More recent research has focused on optimal resuscitation practices for babies with cardiorespiratory depression, such as delayed cord clamping after establishment of ventilation and resuscitation in air. Around a quarter of infants with asystole at 10 min after birth who are subsequently cooled have normal outcomes, suggesting that individualised decision making on stopping resuscitation is needed, based on access to intensive treatment unit and early cooling. The full benefit of cooling appears to have been exploited in our current treatment protocols of 72 hours at 33.5°C; deeper and longer cooling showed adverse outcome. The challenge over the next 5-10 years will be to assess which adjunct therapies are safe and optimise hypothermic brain protection in phase I and phase II trials. Optimal care may require tailoring treatments according to gender, genetic risk, injury severity and inflammatory status.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.