ArticleJournal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer2017
Tumor Spread through Air Spaces Affects the Recurrence and Overall Survival in Patients with Lung Adenocarcinoma >2 to 3 cm.
Article in Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 125 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
125 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- The prognostic significance of tumor spread through air space in stage I lung adenocarcinoma.Thoracic cancer · 2022Pooled it
- Meta-analysis of association between CT-based features and tumor spread through air spaces in lung adenocarcinoma.Journal of cardiothoracic surgery · 2020Pooled it
- Prognostic Impact of Tumor Spread Through Air Spaces in Non-small Cell Lung Cancers: a Meta-Analysis Including 3564 Patients.Pathology oncology research : POR · 2019Pooled it
- Invasive mucinous adenocarcinoma of the lung: integrating molecular landscape, imaging phenotypes, and translational therapeutic strategies.Translational lung cancer research · 2026Review
- Prognostic impact of smoking in non-small cell lung cancer: histology-specific findings from a retrospective cohort study.Translational lung cancer research · 2026Article
- Prognostic Implications of Tumor Spread Through Air Spaces in Patients with Resected Lung Adenocarcinoma.Diagnostics (Basel, Switzerland) · 2026Article
- Dual-layer spectral CT for predicting spread through air spaces in lung adenocarcinoma: a dual-center study.European radiology · 2026Article
- Impact of Spread Through Air Spaces on Outcomes After Uniportal VATS Resection for Lung Adenocarcinoma: A Propensity Score-Matched Analysis.Journal of personalized medicine · 2026Article
- Tumor Spread through Air Spaces in Early-Stage Lung Adenocarcinoma: Surgical Implications and Patient Management Strategies.Journal of chest surgery · 2026Review
- Long-Term Outcomes of Indocyanine Green Versus Inflation-Deflation for Intersegmental Plane Identification in Segmentectomy for Early-Stage Lung Cancer.Interdisciplinary cardiovascular and thoracic surgery · 2026Article
- Optimizing surgical decision-making for lung adenocarcinoma by preoperatively identifying pathological high-risk factors: retrospective development and prospective validation of a deep learning model.International journal of surgery (London, England) · 2026Article
- Head-to-head comparison of maximum standardized uptake value and three-dimensional consolidation-to-tumor ratio for preoperative prediction of International Association for the Study of Lung Cancer grade 3 in clinical stage IA invasive lung adenocarcinoma.Journal of thoracic disease · 2026Article
- Diffusion attention expert model for predicting and semi-automatic localizing STAS in lung cancer histopathological images.Nature communications · 2026Article
- STAS More than a Prognostic Marker-An Evolving Factor in Operative and Adjuvant Treatment Decisions in Early-Stage NSCLC.Cancers · 2026Review
- Radiological, Molecular, and Pathological Factors Unite: A Model for Predicting Recurrence-Free Survival in Pathological Stage I Lung Adenocarcinoma.Thoracic cancer · 2026Article
- Imaging advances of predicting spread through air spaces (STAS) in lung cancer: a narrative review.Journal of thoracic disease · 2026Review
- Preoperative predictive factors and the prognostic impact of spread through air spaces in clinical stage IA lung adenocarcinoma.Surgery today · 2026Article
- Computed tomography-based tumoral and peritumoral radiomics models for preoperative prediction of the spread through air spaces in patients with clinical stage I pure solid invasive lung adenocarcinoma: a multicenter study.Journal of thoracic disease · 2026Article
- Correlations and prognostic impacts of tumor spread through airspaces in surgically resected non-small cell lung cancer: a retrospective study from Jordan.Journal of pathology and translational medicine · 2026Article
- Nomogram based on computed tomography fractal dimension for predicting spread through air spaces in lung adenocarcinoma.Frontiers in medicine · 2026Article
65 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
- Commented on by
- Commented on by
- Commented on by
Authors and funding
16 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTumor spread through air spaces (STAS) is a novel invasive pattern in lung adenocarcinoma (ADC). The effects of the combination of STAS and tumor size on survival have not been well studied.
methodsA total of 383 patients with ADC 3 cm or smaller (stage IA) and 161 patients with stage IB ADC were identified from 2009 to 2010. Recurrence-free survival (RFS) and overall survival (OS) were compared between patients as stratified by STAS and tumor size. A validation cohort was included in this study.
resultsSTAS was observed in 116 ADCs 3 cm or smaller (30.3%). In cases involving ADCs 3 cm or smaller, patients with STAS had worse RFS (p = 0.006) and OS rates (p < 0.001) than those without STAS. Furthermore, comparable RFS (p = 0.091) and OS (p = 0.443) rates were observed in patients with ADCs 3 cm or smaller with STAS present and those with stage IB ADC. Multivariate analysis revealed STAS to be an independent prognostic factor in ADCs 3 cm or smaller (RFS, p = 0.043; OS, p = 0.009). Among patients with ADCs larger than 2 to 3 cm, STAS still stratified the prognosis. Moreover, the unfavorable prognosis of patients with ADCs larger than 2 to 3 cm with STAS present was similar to that of patients with stage IB ADC. Among patients with ADCs 2 cm or smaller, STAS failed to stratify the prognosis significantly. Similar results were obtained in the validation cohort.
conclusionsThese results provide preliminary evidence that STAS could be considered as a factor in a staging system to predict prognosis more precisely, especially in ADCs larger than 2 to 3 cm.
Indexed as
Identifiers
28389373What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.