Evidence map›Paper›PMID 28389140›Full record

ArticlePharmacology, biochemistry, and behavior2017

Sex differences in aripiprazole sensitization from adolescence to adulthood.

Elizabeth Freeman, Joanne Lin, Shinnyi Chow, Collin Davis, Ming Li

Erratum issuedOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pharmacology, biochemistry, and behavior, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Elizabeth FreemanDepartment of Psychology, University of Nebraska-Lincoln, Lincoln, NE 68588-0308, USA. Electronic address: efreeman7@unl.edu.
Joanne LinDepartment of Psychology, University of Nebraska-Lincoln, Lincoln, NE 68588-0308, USA.
Shinnyi ChowDepartment of Psychology, University of Nebraska-Lincoln, Lincoln, NE 68588-0308, USA.
Collin DavisDepartment of Psychology, University of Nebraska-Lincoln, Lincoln, NE 68588-0308, USA.
Ming LiDepartment of Psychology, University of Nebraska-Lincoln, Lincoln, NE 68588-0308, USA.
University of Nebraska–Lincoln · US

Funding

Adolescence neurogenesis mechanisms of antipsychotic sensitization and toleranceR03HD079870 · NICHD · UNIVERSITY OF NEBRASKA LINCOLN · PI LI, MING · 2015 to 2016
$157k
NICHD NIH HHS R03 HD079870
6 · The paper itself

Abstract

The present study investigated the potential sex differences in repeated aripiprazole (ARI) treatment-induced behavioral sensitization from adolescence to adulthood, and to determine whether ARI sensitization can be transferred to olanzapine (OLZ) and/or clozapine (CLZ) using the conditioned avoidance response (CAR) and phencyclidine-induced (PCP) hyperlocomotion tests of antipsychotic activity. Male and female Sprague-Dawley adolescence rats (P46) were first treated with ARI (10mg/kg) for 5 consecutive days (P46-50) and tested for avoidance response and ARI-induced inhibition of PCP-induced hyperlocomotion. After they became adults (>P68), rats were challenged with ARI (1.5mg/kg, sc) (P70), OLZ (0.5mg/kg, sc; P73), CLZ (5mg/kg, sc; P76) and again with ARI (1.5mg/kg, sc; P84) and tested for avoidance response and ARI-induced inhibition of PCP-induced hyperlocomotion again. During the drug treatment period in adolescence, repeated ARI treatment suppressed avoidance response, inhibited the PCP-induced hyperlocomotion, and these effects were progressively increased across the 5-day period in both males and females, confirming the induction of ARI sensitization. On the challenge days, rats previously treated with ARI in adolescence also had significantly lower avoidance and lower PCP-induced hyperlocomotion than the previous vehicle rats, confirming the expression of ARI sensitization and its persistence into adulthood. More importantly, female rats made significantly more avoidances than males in both ARI and vehicle groups, indicating higher sensitivity to the acute and long-term effects of ARI. Further, on the OLZ and CLZ challenge days, prior ARI treatment seemed to increase sensitivity to OLZ exposure, however, this increase was not significant. Similarly, rats also showed an ARI sensitization to OLZ and CLZ on challenge days. Collectively, results from this experiment demonstrated a sex difference in response to ARI and enhanced inhibition of PCP-induced hyperlocomotion in animals that were pretreated with ARI as compared to controls.

Indexed as

Age FactorsSex FactorsAnimalsAntipsychotic AgentsAripiprazoleAvoidance LearningFemaleLocomotionMalePhencyclidineRatsRats, Sprague-DawleyAntipsychotic AgentsAripiprazolePhencyclidineAripiprazoleConditioned avoidance responseDevelopmentPhencyclidineSensitizationSex difference

Identifiers

PMID28389140
PMCPMC5716957
OpenAlexW2604420042

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.