ArticleNeurobiology of aging2017
Sources of disconnection in neurocognitive aging: cerebral white-matter integrity, resting-state functional connectivity, and white-matter hyperintensity volume.
Article in Neurobiology of aging, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 2 of them syntheses that pooled it.
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Who cites it
37 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- The older adult brain is less modular, more integrated, and less efficient at rest: A systematic review of large-scale resting-state functional brain networks in aging.Psychophysiology · 2023Pooled it
- Functional connectivity changes in cerebral small vessel disease - a systematic review of the resting-state MRI literature.BMC medicine · 2021Pooled it
- Contributions of Gray Matter Microstructure to Differences in Fluid Cognition and Episodic Memory Across the Healthy Adult Lifespan.Human brain mapping · 2026Article
- Depthwise cortical iron relates to functional connectivity and fluid cognition in healthy aging.Neurobiology of aging · 2025Article
- High-resolution structural connectivity mediates age-related differences in functional connectivity and fluid cognition.Brain communications · 2025Article
- Distributed associations among white matter hyperintensities and structural brain networks with fluid cognition in healthy aging.Cognitive, affective & behavioral neuroscience · 2024Article
- Age-related differences in resting-state, task-related, and structural brain connectivity: graph theoretical analyses and visual search performance.Brain structure & function · 2024Article
- Leptin bioavailability and markers of brain atrophy and vascular injury in the middle age.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- In vivo microstructural heterogeneity of white matter and cognitive correlates in aging using tissue compositional analysis of diffusion magnetic resonance imaging.Human brain mapping · 2024Article
- Association of structural connectivity with functional brain network segregation in a middle-aged to elderly population.Frontiers in aging neuroscience · 2024Article
- Review
- High-resolution multi-shot diffusion imaging of structural networks in healthy neurocognitive aging.NeuroImage · 2023Article
- Age-related differences in frontoparietal activation for target and distractor singletons during visual search.Attention, perception & psychophysics · 2023Article
- Age-related differences in ventral striatal and default mode network function during reciprocated trust.NeuroImage · 2022Article
- A Neuroimaging Signature of Cognitive Aging from Whole-Brain Functional Connectivity.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022Article
- Cerebral White Matter Mediation of Age-Related Differences in Picture Naming Across Adulthood.Neurobiology of language (Cambridge, Mass.) · 2022Article
- Cortical iron mediates age-related decline in fluid cognition.Human brain mapping · 2022Article
- Potential Diffusion Tensor Imaging Biomarkers for Elucidating Intra-Individual Age-Related Changes in Cognitive Control and Processing Speed.Frontiers in aging neuroscience · 2022Article
- Association of Age and Structural Brain Changes With Functional Connectivity and Executive Function in a Middle-Aged to Older Population-Based Cohort.Frontiers in aging neuroscience · 2022Article
- The Clustering Analysis of Time Properties in Patients With Cerebral Small Vessel Disease: A Dynamic Connectivity Study.Frontiers in neurology · 2022Article
Corrections and comments
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Authors and funding
15 authors.
Funding
Abstract
Age-related decline in fluid cognition can be characterized as a disconnection among specific brain structures, leading to a decline in functional efficiency. The potential sources of disconnection, however, are unclear. We investigated imaging measures of cerebral white-matter integrity, resting-state functional connectivity, and white-matter hyperintensity volume as mediators of the relation between age and fluid cognition, in 145 healthy, community-dwelling adults 19-79 years of age. At a general level of analysis, with a single composite measure of fluid cognition and single measures of each of the 3 imaging modalities, age exhibited an independent influence on the cognitive and imaging measures, and the imaging variables did not mediate the age-cognition relation. At a more specific level of analysis, resting-state functional connectivity of sensorimotor networks was a significant mediator of the age-related decline in executive function. These findings suggest that different levels of analysis lead to different models of neurocognitive disconnection, and that resting-state functional connectivity, in particular, may contribute to age-related decline in executive function.
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