ArticleJournal of autoimmunity2017
Mass cytometry identifies a distinct monocyte cytokine signature shared by clinically heterogeneous pediatric SLE patients.
Open access · hybridAbstract read
In one paragraph
Article in Journal of autoimmunity, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
7.3field-weighted citation impact, top 2% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed, 60 citations in OpenAlex.
- Single-cell Unperturbed Activation Profiling by mass cytometry capturesFrontiers in immunology · 2026Article
- Comprehensive immune profiling identifies alterations in adaptive and innate immune responses in granulomatosis with polyangiitis patients in remission.Frontiers in immunology · 2026Article
- Immune ontogeny in childhood-onset systemic lupus erythematosus: effect of immune maturity on disease phenotype and therapeutic responses.Frontiers in immunology · 2026Review
- Mass cytometry: exploring the immune landscape of systemic autoimmune and inflammatory diseases in the past fourteen years.Frontiers in immunology · 2024Review
- Single-cell mass cytometry in immunological skin diseases.Frontiers in immunology · 2024Review
- Dysregulated Lymphocyte Antigen Receptor Signaling in Common Variable Immunodeficiency with Granulomatous Lymphocytic Interstitial Lung Disease.Journal of clinical immunology · 2023Article
- Expansion of extrafollicular B and T cell subsets in childhood-onset systemic lupus erythematosus.Frontiers in immunology · 2023Article
- Serum profiling identifies CCL8, CXCL13, and IL-1RA as markers of active disease in patients with systemic lupus erythematosus.Frontiers in immunology · 2023Article
- Imaging Mass Cytometry Reveals Predominant Innate Immune Signature and Endothelial-Immune Cell Interaction in Juvenile Myositis Compared to Lupus Skin.Arthritis & rheumatology (Hoboken, N.J.) · 2022Article
- Longitudinal Immune Cell Profiling in Patients With Early Systemic Lupus Erythematosus.Arthritis & rheumatology (Hoboken, N.J.) · 2022Article
- Peripheral immunophenotyping of AITD subjects reveals alterations in immune cells in pediatric vs adult-onset AITD.iScience · 2022Article
- CYT387, a JAK-Specific Inhibitor Impedes Osteoclast Activity and Oophorectomy-Induced OsteoporosisFrontiers in pharmacology · 2022Article
- Compositional Data Analysis using Kernels in mass cytometry data.Bioinformatics advances · 2022Article
- Cytokines: From Clinical Significance to Quantification.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2021Review
- Co-evolution of tumor and immune cells during progression of multiple myeloma.Nature communications · 2021Article
- Subjects at-risk for future development of rheumatoid arthritis demonstrate a PAD4-and TLR-dependent enhanced histone H3 citrullination and proinflammatory cytokine production in CD14Journal of autoimmunity · 2021Article
- High Throughput Multi-Omics Approaches for Clinical Trial Evaluation and Drug Discovery.Frontiers in immunology · 2021Review
- Single-cell mass cytometry on peripheral blood identifies immune cell subsets associated with primary biliary cholangitis.Scientific reports · 2020Article
- VoPo leverages cellular heterogeneity for predictive modeling of single-cell data.Nature communications · 2020Article
- Deep Profiling of Cellular Heterogeneity by Emerging Single-Cell Proteomic Technologies.Proteomics · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 4 institutions in 1 country.
W E O'GormanDepartment of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA.
D S KongDepartment of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, CO 80045, USA.
I M BalboniDepartment of Pediatrics, Division of Allergy, Immunology and Rheumatology, Stanford University School of Medicine, Stanford, CA 94305, USA.
P RudraDepartment of Biostatistics and Informatics, Colorado School of Public Health, Aurora, CO 80045, USA.
C R BolenDepartment of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, CO 80045, USA.
D GhoshDepartment of Biostatistics and Informatics, Colorado School of Public Health, Aurora, CO 80045, USA.
M M DavisDepartment of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA; Institute for Immunity, Transplantation and Infection, Stanford University, Stanford, CA 94305, USA; The Howard Hughes Medical Institute, Stanford University, Stanford, CA 94305, USA.
G P NolanDepartment of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA; Institute for Immunity, Transplantation and Infection, Stanford University, Stanford, CA 94305, USA.
E W Y HsiehDepartment of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA; Department of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, CO 80045, USA; Department of Pediatrics, Division of Allergy, Immunology and Rheumatology, Stanford University School of Medicine, Stanford, CA 94305, USA; Department of Pediatrics, Division of Allergy and Immunology, University of Colorado School of Medicine, Aurora, CO 80045, USA. Electronic address: elena.hsieh@ucdenver.edu.
Stanford University · USUniversity of Colorado Denver · USColorado School of Public Health · USHoward Hughes Medical Institute · US
Funding
Using a tonsil organoid system to probe conditions for the induction of protective antibody and T cell responses to influenza.U19AI057229 · NIAID · STANFORD UNIVERSITY · PI Mark Morris Davis · 2003 to 2026
$88.5MSystems Biology CoreU19AI100627 · NIAID · SCRIPPS RESEARCH INSTITUTE, THE · PI ULEVITCH, RICHARD J · 2012 to 2021
$49.1MPediatric Scientist Development Program (PSDP) [K12]K12HD000850 · NICHD · YALE UNIVERSITY · PI Sallie R. Permar · 1987 to 2026
$44.1MSpectrum Stanford Center for clinical and Translational Research and EducationUL1TR001085 · NCATS · STANFORD UNIVERSITY · PI CULLEN, MARK RICHARD, GREENBERG, HARRY BERNARD · 2013 to 2017
$37.1MMOLECULAR &CELLULAR IMMUNOBIOLOGYT32AI007290 · NIAID · STANFORD UNIVERSITY · PI Sean Curtis Bendall, Olivia M Martinez · 1985 to 2026
$27.0MVaccination and infection: indicators of immunological health and responsivenessU19AI090019 · NIAID · STANFORD UNIVERSITY · PI DAVIS, MARK MORRIS · 2010 to 2015
$17.3MMODELING THE ROLE OF PROGRESSION IN FOLLICULAR LYMPHOMAU54CA149145 · NCI · STANFORD UNIVERSITY · PI PLEVRITIS, SYLVIA KATINA · 2010 to 2014
$12.1M(PQD2)New Biomarkers and Pathways to Enhance Cure in Ovarian CancersR01CA184968 · NCI · STANFORD UNIVERSITY · PI FANTL, WENDY JANE, SIKIC, BRANIMIR I · 2014 to 2017
$2.0MHighly multiplexed ion-beam tissue molecular imaging with sub-micron resolutionR33CA183654 · NCI · STANFORD UNIVERSITY · PI NOLAN, GARRY P · 2014 to 2016
$1.2MIntegrating mass cytometric and transcriptomic profiles of solid tumorsR33CA183692 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI WEISS, WILLIAM A · 2014 to 2016
$1.2MProteomic Analyses of Pediatric Systemic Lupus ErythematosusK08AI080945 · NIAID · STANFORD UNIVERSITY · PI BALBONI, IMELDA MARIE · 2009 to 2013
$654kNCATS NIH HHS UL1 TR001085NCI NIH HHS R01 CA184968NCI NIH HHS R33 CA183654NCI NIH HHS R33 CA183692NCI NIH HHS U54 CA149145NIAID NIH HHS K08 AI080945NIAID NIH HHS L40 AI102061NIAID NIH HHS T32 AI007290NIAID NIH HHS U19 AI057229NIAID NIH HHS U19 AI090019NIAID NIH HHS U19 AI100627NICHD NIH HHS K12 HD000850NICHD NIH HHS L40 HD081583
Abstract
Systemic Lupus Erythematosus (SLE) is a heterogeneous autoimmune disease with heightened disease severity in children. The incomplete understanding of the precise cellular and molecular events that drive disease activity pose a significant hurdle to the development of targeted therapeutic agents. Here, we performed single-cell phenotypic and functional characterization of pediatric SLE patients and healthy controls blood via mass cytometry. We identified a distinct CD14
Indexed as
CytokinesJAK inhibitionMass cytometryMCP1MonocytesPediatric systemic lupus erythematosusPlasma circulating factorsRuxolitinibType I interferons
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.