ArticleParticle and fibre toxicology2017
Deposition efficiency of inhaled particles (15-5000 nm) related to breathing pattern and lung function: an experimental study in healthy children and adults.
Article in Particle and fibre toxicology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Guidelines for assessing maternal cardiovascular physiology during pregnancy and postpartum.American journal of physiology. Heart and circulatory physiology · 2024Guideline
- Aerosol Deposition in the Human Respiratory System from Distinct Urban Sources Using Multiple Exposure Metrics.Environmental science & technology · 2026Article
- Ultrafine Airborne Particle Deposition and Clearance in an Avian Lung under Ecologically Relevant Conditions.Environmental science & technology · 2026Article
- Comparison of personal portable and fixed-site PMScientific reports · 2026Article
- Dynamics of nanoparticles in a 3D breathing lung-on-a-chip.Drug delivery and translational research · 2025Article
- Inhalable nanoparticle-based delivery systems for the treatment of pulmonary infections:Drug delivery · 2025Review
- The Correlation between Metal Mixed Exposure and Lung Function in Different Ages of the Population.Metabolites · 2024Article
- An experimental study on lung deposition of inhaled 2 μm particles in relation to lung characteristics and deposition models.Particle and fibre toxicology · 2023Article
- Toxicological Profile of PM from Different Sources in the Bronchial Epithelial Cell Line BEAS-2B.Toxics · 2023Article
- Investigation of the Exposure of Schoolchildren to Ultrafine Particles (PMInternational journal of environmental research and public health · 2023Article
- A novel in-situ method to determine the respiratory tract deposition of carbonaceous particles reveals dangers of public commuting in highly polluted megacity.Particle and fibre toxicology · 2022Article
- Health risk assessment of particulate matter 2.5 in an academic metallurgy workshop.Indoor air · 2022Article
- Advanced Respiratory Models for Hazard Assessment of Nanomaterials-Performance of Mono-, Co- and Tricultures.Nanomaterials (Basel, Switzerland) · 2022Article
- Intervention of an Upgraded Ventilation System and Effects of the COVID-19 Lockdown on Air Quality at Birmingham New Street Railway Station.International journal of environmental research and public health · 2022Article
- The physics of respiratory particle generation, fate in the air, and inhalation.Nature reviews. Physics · 2022Review
- Modeling airborne pathogen transport and transmission risks of SARS-CoV-2.Applied mathematical modelling · 2021Article
- Health Risk Assessment of PMInternational journal of environmental research and public health · 2021Article
- The Effect of Aging on Aerosol Bolus Deposition in the Healthy Adult Lung: A 19-Year Longitudinal Study.Journal of aerosol medicine and pulmonary drug delivery · 2020Article
- Development of an ex vivo preclinical respiratory model of idiopathic pulmonary fibrosis for aerosol regional studies.Scientific reports · 2019Article
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Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundExposure to airborne particles has a major impact on global health. The probability of these particles to deposit in the respiratory tract during breathing is essential for their toxic effects. Observations have shown that there is a substantial variability in deposition between subjects, not only due to respiratory diseases, but also among individuals with healthy lungs. The factors determining this variability are, however, not fully understood.
methodIn this study we experimentally investigate factors that determine individual differences in the respiratory tract depositions of inhaled particles for healthy subjects at relaxed breathing. The study covers particles of diameters 15-5000 nm and includes 67 subjects aged 7-70 years. A comprehensive examination of lung function was performed for all subjects. Principal component analyses and multiple regression analyses were used to explore the relationships between subject characteristics and particle deposition.
resultsA large individual variability in respiratory tract deposition efficiency was found. Individuals with high deposition of a certain particle size generally had high deposition for all particles <3500 nm. The individual variability was explained by two factors: breathing pattern, and lung structural and functional properties. The most important predictors were found to be breathing frequency and anatomical airway dead space. We also present a linear regression model describing the deposition based on four variables: tidal volume, breathing frequency, anatomical dead space and resistance of the respiratory system (the latter measured with impulse oscillometry).
conclusionsTo understand why some individuals are more susceptible to airborne particles we must understand, and take into account, the individual variability in the probability of particles to deposit in the respiratory tract by considering not only breathing patterns but also adequate measures of relevant structural and functional properties.
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