ArticleBMC veterinary research2017
Characterization and virulence clustering analysis of extraintestinal pathogenic Escherichia coli isolated from swine in China.
Article in BMC veterinary research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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23 citing papers in PubMed.
- Identification and Genomic Characterization of a Novel Teseptimavirus Species (vB_EcoP_S37A) and a Mosigvirus Phage (vB_EcoM_S37) Infecting Swine Extraintestinal PathogenicVeterinary sciences · 2026Article
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- Emergence of porcine-derived hybridVirulence · 2025Article
- Prevalence, Phylogenetic Distribution, Antimicrobial Resistance, and Genetic Relatedness of Extraintestinal PathogenicVeterinary sciences · 2025Article
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- Comprehensive Analysis ofMicroorganisms · 2025Article
- Population structure and antibiotic resistance of swine extraintestinal pathogenic Escherichia coli from China.Nature communications · 2024Article
- Baicalin Weakens the Virulence of Porcine Extraintestinal PathogenicBiomolecules · 2024Article
- Antibacterial activity of the antimicrobial peptide PMAP-36 in combination with tetracycline against porcine extraintestinal pathogenic Escherichia coli in vitro and in vivo.Veterinary research · 2024Article
- Article
- Genome-wide identification of genes critical forVirulence · 2023Article
- Baicalin Weakens the Porcine ExPEC-Induced Inflammatory Response in 3D4/21 Cells by Inhibiting the Expression of NF-Microorganisms · 2023Article
- Porcine extraintestinal pathogenicFrontiers in cellular and infection microbiology · 2023Article
- Whole Genome Sequencing and Biological Characteristics of Two Strains of Porcine Escherichia coli Isolated from Saba Pigs.Current microbiology · 2022Article
- Mobile colistin resistance (MCR), extended-spectrum beta-lactamase (ESBL) and multidrug resistance monitoring inFrontiers in microbiology · 2022Article
- A One Health Perspective for Defining and DecipheringComparative medicine · 2021Review
- Insight Into the Virulence Related Secretion Systems, Fimbriae, and Toxins in O2:K1Frontiers in veterinary science · 2021Article
- Multi-Locus Sequence Typing and Drug Resistance Analysis of Swine OriginFrontiers in public health · 2021Article
- Distinguishing Pathovars from Nonpathovars: Escherichia coli.Microbiology spectrum · 2020Review
- Extended Phylogeny and Extraintestinal Virulence Potential of CommensalInternational journal of environmental research and public health · 2020Article
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8 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundSwine extraintestinal pathogenic Escherichia coli (ExPEC) is an important pathogen that leads to economic and welfare costs in the swine industry worldwide, and is occurring with increasing frequency in China. By far, various virulence factors have been recognized in ExPEC. Here, we investigated the virulence genotypes and clonal structure of collected strains to improve the knowledge of phylogenetic traits of porcine ExPECs in China.
resultsWe isolated 64 Chinese porcine ExPEC strains from 2013 to 14 in China. By multiplex PCR, the distribution of isolates belonging to phylogenetic groups B1, B2, A and D was 9.4%, 10.9%, 57.8% and 21.9%, respectively. Nineteen virulence-related genes were detected by PCR assay; ompA, fimH, vat, traT and iutA were highly prevalent. Virulence-related genes were remarkably more prevalent in group B2 than in groups A, B1 and D; notably, usp, cnf1, hlyD, papA and ibeA were only found in group B2 strains. Genotyping analysis was performed and four clusters of strains (named I to IV) were identified. Cluster IV contained all isolates from group B2 and Cluster IV isolates had the strongest pathogenicity in a mouse infection model. As phylogenetic group B2 and D ExPEC isolates are generally considered virulent, multilocus sequence typing (MLST) analysis was performed for these isolates to further investigate genetic relationships. Two novel sequence types, ST5170 and ST5171, were discovered. Among the nine clonal complexes identified among our group B2 and D isolates, CC12 and CC95 have been indicated to have high zoonotic pathogenicity. The distinction between group B2 and non-B2 isolates in virulence and genotype accorded with MLST analysis.
conclusionThis study reveals significant genetic diversity among ExPEC isolates and helps us to better understand their pathogenesis. Importantly, our data suggest group B2 (Cluster IV) strains have the highest risk of causing animal disease and illustrate the correlation between genotype and virulence.
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