ReviewInfectious diseases of poverty2017
Putting the treatment of paediatric schistosomiasis into context.
Review in Infectious diseases of poverty, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 35 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Health Benefits of Repeated Treatment in Pediatric Schistosomiasis
Childhood Schistosomiasis: a Novel Strategy Extending the Benefits/Reach of Antihelminthic Treatment
Who cites it
35 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Effects of paediatric schistosomiasis control programmes in sub-Saharan Africa: A systematic review.PloS one · 2024Pooled it
- Soil-transmitted helminths and schistosome infections in Ethiopia: a systematic review of progress in their control over the past 20 years.Parasites & vectors · 2021Pooled it
- Pooled it
- Knowledge, attitudes and practices on Schistosomiasis in sub-Saharan Africa: a systematic review.BMC infectious diseases · 2018Pooled it
- Fine-scale heterogeneity inProceedings of the National Academy of Sciences of the United States of America · 2020Trial
- Schistosomiasis Knowledge, Attitudes, and Practices Among School-Going Children Aged 5-14 Years in Nelson Mandela Bay (NMB), South Africa.Journal of parasitology research · 2026Article
- Prevalence, intensity, and associated factors of soil-transmitted helminth and schistosome infections after multiple rounds of preventive chemotherapy among schoolchildren in five selected district councils in Tanzania.PLoS neglected tropical diseases · 2025Article
- Changes in schistosomiasis prevalence after 2 years of an integrated intervention in the Itilima district of Tanzania.Parasites, hosts and diseases · 2025Article
- National Consensus on Introducing and Delivery of Paediatric Praziquantel for Curative and Preventive Treatment of Schistosomiasis Among Pre-school Children in Tanzania.The East African health research journal · 2025Article
- Schistosomiasis in migrant children and adolescents in a paediatric tropical referral unit in Spain: diagnosis and long-term management challenges.European journal of pediatrics · 2024Article
- Usefulness of real-time PCR for urogenital schistosomiasis diagnosis in preschool children in a high-prevalence area in Angola.PLoS neglected tropical diseases · 2024Article
- Endemic status of urogenital schistosomiasis and the efficacy of a single-dose praziquantel treatment in unmapped rural farming communities in Oyo East Local Government Area, Oyo State, Nigeria.PLoS neglected tropical diseases · 2024Article
- Where will pediatric praziquantel be needed in Tanzania? Geographical variation in prevalence, and risk factors ofParasite epidemiology and control · 2024Article
- Contextual factors influencing schistosomiasis treatment and identification of delivery platforms for arpraziquantel in hard-to-reach areas and populations in Homa Bay County, Kenya.PLOS global public health · 2024Article
- Prevalence of Schistosomiasis and Soil-Transmitted Helminthiasis and Their Risk Factors: A Cross-Sectional Study in Itilima District, North-Western Tanzania.Life (Basel, Switzerland) · 2023Article
- Patient journey and resources mapping to implement a praziquantel mass drug administration program for children aged 5 years and below in resource-limited settings.Systematic reviews · 2022Article
- Prevalence and risk factors of urogenital schistosomiasis among under-fives in Mtama District in the Lindi region of Tanzania.PLoS neglected tropical diseases · 2022Article
- Therapeutic Efficacy of Carvacrol-Loaded Nanoemulsion in a Mouse Model of Schistosomiasis.Frontiers in pharmacology · 2022Article
- Pharmacogenetics of Praziquantel Metabolism: Evaluating the Cytochrome P450 Genes of Zimbabwean Patients During a Schistosomiasis Treatment.Frontiers in genetics · 2022Article
- Trends in the prevalence of microscopically-confirmed schistosomiasis in the South African public health sector, 2011-2018.PLoS neglected tropical diseases · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Despite increased international efforts to control schistosomiasis using preventive chemotherapy, several challenges still exist in reaching the target populations. Until recently, preschool-aged children had been excluded from the recommended target population for mass drug administration, i.e. primary school children aged 6-15 years. Our studies and those of others provided the evidence base for the need to treat preschool-aged children that led to recommendations by the World Health Organization to include preschool-aged children in treatment programmes in 2010. The major challenge now lies in the unavailability of a child-size formulation of the appropriate anthelmintic drug, praziquantel.The currently available formulation of praziquantel presents several problems. First, it is a large tablet, making it difficult for young children and infants to swallow it and thus requires its breaking/crushing to allow for safe uptake. Second, it is bitter so it is often mixed with a sweetener to make it palatable for young children. Third, the current formulation of 600 mg does not allow for flexible dose adjustments for this age group. Thus, there is a need to formulate a child-appropriate praziquantel tablet.This paper discusses the target product profile for paediatric praziquantel, as well as knowledge gaps pertinent to the successful control of schistosome infection and disease in preschool-aged children.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.