ArticleJournal of nanobiotechnology2017
Biodistribution of arctigenin-loaded nanoparticles designed for multimodal imaging.
Article in Journal of nanobiotechnology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Emerging roles of growth factors in osteonecrosis of the femoral head.Frontiers in genetics · 2022Review
- Expression of microRNA‑27a in a rat model of osteonecrosis of the femoral head and its association with TGF‑β/Smad7 signalling in osteoblasts.International journal of molecular medicine · 2019Article
- Systematic understanding of the mechanism and effects of Arctigenin attenuates inflammation in dextran sulfate sodium-induced acute colitis through suppression of NLRP3 inflammasome by SIRT1.American journal of translational research · 2019Article
- Highly hydrophilic carbon nanoparticles: uptake mechanism by mammalian and plant cells.RSC advances · 2018Article
- An Optimized MicroPET Imaging Method for the Distribution and Synergies of Natural Products.Frontiers in pharmacology · 2018Article
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Authors and funding
14 authors.
Funding
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Abstract
backgroundTracking targets of natural products is one of the most challenging issues in fields ranging from pharmacognosy to biomedicine. It is widely recognized that the biocompatible nanoparticle (NP) could function as a "key" that opens the target "lock".
resultsWe report a functionalized poly-lysine NP technique that can monitor the target protein of arctigenin (ATG) in vivo non-invasively. The NPs were synthesized, and their morphologies and surface chemical properties were characterized by transmission electron microscopy (TEM), laser particle size analysis and atomic force microscopy (AFM). In addition, we studied the localization of ATG at the level of the cell and the whole animal (zebrafish and mice). We demonstrated that fluorescent NPs could be ideal carriers in the development of a feasible method for target identification. The distributions of the target proteins were found to be consistent with the pharmacological action of ATG at the cellular and whole-organism levels.
conclusionsThe results indicated that functionalized poly-lysine NPs could be valuable in the multimodal imaging of arctigenin.
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