ArticleThe Journal of clinical endocrinology and metabolism2017
Thyroid and Islet Autoantibodies Predict Autoimmune Thyroid Disease at Type 1 Diabetes Diagnosis.
Article in The Journal of clinical endocrinology and metabolism, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 2 of them syntheses that pooled it.
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Who cites it
27 citing papers in PubMed, 2 syntheses or guidelines pooled it, 45 citations in OpenAlex.
- ISPAD Clinical Practice Consensus Guidelines 2018: Other complications and associated conditions in children and adolescents with type 1 diabetes.Pediatric diabetes · 2018Guideline
- Type 1 Diabetes in Children and Adolescents: A Position Statement by the American Diabetes Association.Diabetes care · 2018Guideline
- Increasing Co-occurrence of Additional Autoimmune Disorders at Diabetes Type 1 Onset Among Children and Adolescents Diagnosed in Years 2010-2018-Single-Center Study.Frontiers in endocrinology · 2020Trial
- Multi-omics reveals microbiota, metabolite, and immunological heterogeneity of age-related endotypes in type 1 diabetes.Signal transduction and targeted therapy · 2026Article
- Thyroid autoimmunity in relation to islet autoantibodies in newly diagnosed type 1 diabetes mellitus in children and adolescents.Frontiers in endocrinology · 2026Article
- 14. Children and Adolescents: Standards of Care in Diabetes-2026.Diabetes care · 2026Review
- Clinical and serological characteristics of type 3 APS, isolated T1DM and LADY/LADA.BMC endocrine disorders · 2025Article
- 14. Children and Adolescents: Standards of Care in Diabetes-2025.Diabetes care · 2025Review
- Thyroid autoimmunity at onset of type 1 diabetes as a predictor of thyroid dysfunction: a thirty-years retrospective longitudinal study.Frontiers in endocrinology · 2025Article
- 14. Children and Adolescents: Standards of Care in Diabetes-2024.Diabetes care · 2024Review
- 14. Children and Adolescents: Standards of Care in Diabetes-2023.Diabetes care · 2023Review
- Islet Autoantibody Level Distribution in Type 1 Diabetes and Their Association With Genetic and Clinical Characteristics.The Journal of clinical endocrinology and metabolism · 2022Article
- Clinical Significance of Diabetes-Mellitus-Associated Antibodies in Rheumatoid Arthritis.Cells · 2022Article
- Predictors of associated and multiple autoimmunity in children and adolescents with type 1 diabetes mellitus.Annals of pediatric endocrinology & metabolism · 2022Article
- Infectious diseases associated with pediatric type 1 diabetes mellitus: A narrative review.Frontiers in endocrinology · 2022Review
- Increased Frequency of Diabetic Ketoacidosis: The Link With COVID-19 Pandemic.Frontiers in clinical diabetes and healthcare · 2022Article
- Article
- Autoimmune thyroid disease correlates to islet autoimmunity on zinc transporter 8 autoantibody.Endocrine connections · 2021Article
- The thyroid hormone levels and glucose and lipid metabolism in children with type 1 diabetes: a correlation analysis.Translational pediatrics · 2021Article
- Gluten intake and risk of thyroid peroxidase autoantibodies in the Diabetes Autoimmunity Study In the Young (DAISY).Endocrine · 2020Article
Corrections and comments
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Authors and funding
12 authors at 5 institutions in 1 country.
Funding
Abstract
Context: Screening of autoimmune thyroid disease in children with type 1 diabetes is important but varies between clinics. Objective: To determine the predictive value of thyroid autoantibodies, thyroid function, islet autoantibodies, and HLA-DQ at diagnosis of type 1 diabetes for autoimmune thyroid disease during follow-up. Setting: Forty-three Swedish pediatric endocrinology units. Design, Patients, and Main Outcome Measures: At diagnosis of type 1 diabetes, autoantibodies against thyroid peroxidase (TPOAb), thyroglobulin (TGAb), glutamic acid decarboxylase (GADA), insulin, insulinoma-associated protein-2, and 3 variants of zinc transporter 8 (ZnT8W/R/QA) HLA-DQA1-B1 genotypes and thyroid function were analyzed in 2433 children. After 5.1 to 9.5 years, information on thyroxine treatment was gathered from the Swedish National Board of Health and Welfare's Prescribed Drug Register. Results: Thyroxine was prescribed to 6% of patients. In patients <5 years of age, female sex [hazard ratio (HR) = 4.60; P = 0.008] and GADA (HR = 5.80; P = 0.02) were predictors. In patients 5 to 10 years old, TPOAb (HR = 20.56; P < 0.0001), TGAb (HR = 3.40; P = 0.006), and thyroid-stimulating hormone (TSH) (HR = 3.64; P < 0.001) were predictors, whereas in 10 to 15 year olds, TPOAb (HR = 17.00; P < 0.001) and TSH (HR = 4.11; P < 0.001) predicted thyroxine prescription. Conclusion: In addition to TPOAb and TSH, GADA at diagnosis of type 1 diabetes is important for the prediction of autoimmune thyroid disease in children <5 years of age.
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