ArticlePloS one2017
Combining clinical and genomics queries using i2b2 - Three methods.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed.
- PIC-SURE: an open-source platform for integrating clinical and genomic data.NPJ digital medicine · 2025Article
- Research data warehouse best practices: catalyzing national data sharing through informatics innovation.Journal of the American Medical Informatics Association : JAMIA · 2022Article
- A Review of the Role and Challenges of Big Data in Healthcare Informatics and Analytics.Computational intelligence and neuroscience · 2022Review
- Scalable analysis of multi-modal biomedical data.GigaScience · 2021Article
- Enabling Precision Medicine in Cancer Care Through a Molecular Data Warehouse: The Moffitt Experience.JCO clinical cancer informatics · 2021Article
- Integrating Genomics and Clinical Data for Statistical Analysis by Using GEnome MINIng (GEMINI) and Fast Healthcare Interoperability Resources (FHIR): System Design and Implementation.Journal of medical Internet research · 2020Article
- Advancing clinical cohort selection with genomics analysis on a distributed platform.PloS one · 2020Article
- PlatformTM, a standards-based data custodianship platform for translational medicine research.Scientific data · 2019Article
- Phenotyping to Facilitate Accrual for a Cardiovascular Intervention.Journal of clinical medicine research · 2019Article
- The Association of Black Cardiologists (ABC) Cardiovascular Implementation Study (CVIS): A Research Registry Integrating Social Determinants to Support Care for Underserved Patients.International journal of environmental research and public health · 2019Article
- Integrating Multimodal Radiation Therapy Data into i2b2.Applied clinical informatics · 2018Article
- Enhancing the Representational Power of i2b2 through Referent Tracking.AMIA ... Annual Symposium proceedings. AMIA Symposium · 2018Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
We are fortunate to be living in an era of twin biomedical data surges: a burgeoning representation of human phenotypes in the medical records of our healthcare systems, and high-throughput sequencing making rapid technological advances. The difficulty representing genomic data and its annotations has almost by itself led to the recognition of a biomedical "Big Data" challenge, and the complexity of healthcare data only compounds the problem to the point that coherent representation of both systems on the same platform seems insuperably difficult. We investigated the capability for complex, integrative genomic and clinical queries to be supported in the Informatics for Integrating Biology and the Bedside (i2b2) translational software package. Three different data integration approaches were developed: The first is based on Sequence Ontology, the second is based on the tranSMART engine, and the third on CouchDB. These novel methods for representing and querying complex genomic and clinical data on the i2b2 platform are available today for advancing precision medicine.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.