ArticlePLoS genetics2017
The evolution of Sex-linked barring alleles in chickens involves both regulatory and coding changes in CDKN2A.
Article in PLoS genetics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 43 citations in OpenAlex.
- Transcriptomic Analysis IdentifiesAnimals : an open access journal from MDPI · 2026Article
- Insights into the mechanism underlying feather pattern formation of sex-linked barring in Chinese native chickens.Poultry science · 2026Article
- Effects ofJournal of animal science and technology · 2025Article
- Organizational principles of integumentary organs: Maximizing variations for effective adaptation.Developmental biology · 2025Review
- Transcriptomic insights into the effects of tyrosine on sub-Columbian plumage in H line chickens.Frontiers in veterinary science · 2025Article
- Low Mutation Load in a Supergene Underpinning Alternative Male Mating Strategies in Ruff (Calidris pugnax).Molecular biology and evolution · 2023Article
- Effects of SLC45A2 and GPNMB on Melanin Deposition Based on Transcriptome Sequencing in Chicken Feather Follicles.Animals : an open access journal from MDPI · 2023Article
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- Comprehensive analysis of structural variants in chickens using PacBio sequencing.Frontiers in genetics · 2022Article
- The feather pattern autosomal barring in chicken is strongly associated with segregation at the MC1R locus.Pigment cell & melanoma research · 2021Article
- Article
- Making region-specific integumentary organs in birds: evolution and modifications.Current opinion in genetics & development · 2021Review
- Direct allele introgression into pure chicken breeds using Sire Dam Surrogate (SDS) mating.Nature communications · 2021Article
- Transcriptome analysis of feather follicles reveals candidate genes and pathways associated with pheomelanin pigmentation in chickens.Scientific reports · 2020Article
- Instructive role of melanocytes during pigment pattern formation of the avian skin.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- A comparison of the association between large haplotype blocks under selection and the presence/absence of inversions.Ecology and evolution · 2019Article
Corrections and comments
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Authors and funding
15 authors at 4 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sex-linked barring is a fascinating plumage pattern in chickens recently shown to be associated with two non-coding and two missense mutations affecting the ARF transcript at the CDKN2A tumor suppressor locus. It however remained a mystery whether all four mutations are indeed causative and how they contribute to the barring phenotype. Here, we show that Sex-linked barring is genetically heterogeneous, and that the mutations form three functionally different variant alleles. The B0 allele carries only the two non-coding changes and is associated with the most dilute barring pattern, whereas the B1 and B2 alleles carry both the two non-coding changes and one each of the two missense mutations causing the Sex-linked barring and Sex-linked dilution phenotypes, respectively. The data are consistent with evolution of alleles where the non-coding changes occurred first followed by the two missense mutations that resulted in a phenotype more appealing to humans. We show that one or both of the non-coding changes are cis-regulatory mutations causing a higher CDKN2A expression, whereas the missense mutations reduce the ability of ARF to interact with MDM2. Caspase assays for all genotypes revealed no apoptotic events and our results are consistent with a recent study indicating that the loss of melanocyte progenitors in Sex-linked barring in chicken is caused by premature differentiation and not apoptosis. Our results show that CDKN2A is a major locus driving the differentiation of avian melanocytes in a temporal and spatial manner.
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